FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019977862> ?p ?o ?g. }

• W2019977862 endingPage "1246" @default.
• W2019977862 startingPage "1241" @default.
• W2019977862 abstract "Glutathione S-transferases (GSTs) are involved in detoxification of xenobiotic compounds and in the biosynthesis of important metabolites. All GSTs activate glutathione (GSH) to GS−; in many GSTs, this is accomplished by a Tyr at H-bonding distance from the sulfur of GSH. The high-resolution structure of GST from Schistosoma haematobium revealed that the catalytic Tyr occupies two alternative positions, one external, involving a π-cation interaction with the conserved Arg21, and the other inside the GSH binding site. The interaction with Arg21 lowers the pKa of the catalytic Tyr10, as required for catalysis. Examination of several other GST structures revealed the presence of an external pocket that may accommodate the catalytic Tyr, and suggested that the change in conformation and acidic properties of the catalytic Tyr may be shared by other GSTs. Arginine and two other residues of the external pocket constitute a conserved structural motif, clearly identified by sequence comparison." @default.
• W2019977862 created "2016-06-24" @default.
• W2019977862 creator A5032998349 @default.
• W2019977862 creator A5069801345 @default.
• W2019977862 creator A5070039736 @default.
• W2019977862 creator A5070413439 @default.
• W2019977862 creator A5076021638 @default.
• W2019977862 creator A5090015641 @default.
• W2019977862 date "2005-09-01" @default.
• W2019977862 modified "2023-10-13" @default.
• W2019977862 title "Insights into the Catalytic Mechanism of Glutathione S-Transferase: The Lesson from Schistosoma haematobium" @default.
• W2019977862 cites W105839754 @default.
• W2019977862 cites W1489526459 @default.
• W2019977862 cites W1968361665 @default.
• W2019977862 cites W1987773676 @default.
• W2019977862 cites W1990357483 @default.
• W2019977862 cites W1991998329 @default.
• W2019977862 cites W1998980013 @default.
• W2019977862 cites W2008628409 @default.
• W2019977862 cites W2012364969 @default.
• W2019977862 cites W2023287483 @default.
• W2019977862 cites W2028767577 @default.
• W2019977862 cites W2029395503 @default.
• W2019977862 cites W2037946624 @default.
• W2019977862 cites W2053789002 @default.
• W2019977862 cites W2054525948 @default.
• W2019977862 cites W2062501429 @default.
• W2019977862 cites W2064098131 @default.
• W2019977862 cites W2064113328 @default.
• W2019977862 cites W2074461690 @default.
• W2019977862 cites W2086759672 @default.
• W2019977862 cites W2092286579 @default.
• W2019977862 cites W2094893844 @default.
• W2019977862 cites W2097224528 @default.
• W2019977862 cites W2105902442 @default.
• W2019977862 cites W2154011403 @default.
• W2019977862 cites W2161062388 @default.
• W2019977862 cites W2166735590 @default.
• W2019977862 cites W4233291509 @default.
• W2019977862 cites W8040729 @default.
• W2019977862 doi "https://doi.org/10.1016/j.str.2005.06.007" @default.
• W2019977862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16154081" @default.
• W2019977862 hasPublicationYear "2005" @default.
• W2019977862 type Work @default.
• W2019977862 sameAs 2019977862 @default.
• W2019977862 citedByCount "44" @default.
• W2019977862 countsByYear W20199778622012 @default.
• W2019977862 countsByYear W20199778622013 @default.
• W2019977862 countsByYear W20199778622014 @default.
• W2019977862 countsByYear W20199778622017 @default.
• W2019977862 countsByYear W20199778622018 @default.
• W2019977862 countsByYear W20199778622019 @default.
• W2019977862 countsByYear W20199778622020 @default.
• W2019977862 countsByYear W20199778622021 @default.
• W2019977862 countsByYear W20199778622022 @default.
• W2019977862 countsByYear W20199778622023 @default.
• W2019977862 crossrefType "journal-article" @default.
• W2019977862 hasAuthorship W2019977862A5032998349 @default.
• W2019977862 hasAuthorship W2019977862A5069801345 @default.
• W2019977862 hasAuthorship W2019977862A5070039736 @default.
• W2019977862 hasAuthorship W2019977862A5070413439 @default.
• W2019977862 hasAuthorship W2019977862A5076021638 @default.
• W2019977862 hasAuthorship W2019977862A5090015641 @default.
• W2019977862 hasBestOaLocation W20199778621 @default.
• W2019977862 hasConcept C115448650 @default.
• W2019977862 hasConcept C161790260 @default.
• W2019977862 hasConcept C181199279 @default.
• W2019977862 hasConcept C185592680 @default.
• W2019977862 hasConcept C2776376580 @default.
• W2019977862 hasConcept C2776907368 @default.
• W2019977862 hasConcept C3019047270 @default.
• W2019977862 hasConcept C538909803 @default.
• W2019977862 hasConcept C55493867 @default.
• W2019977862 hasConcept C71240020 @default.
• W2019977862 hasConceptScore W2019977862C115448650 @default.
• W2019977862 hasConceptScore W2019977862C161790260 @default.
• W2019977862 hasConceptScore W2019977862C181199279 @default.
• W2019977862 hasConceptScore W2019977862C185592680 @default.
• W2019977862 hasConceptScore W2019977862C2776376580 @default.
• W2019977862 hasConceptScore W2019977862C2776907368 @default.
• W2019977862 hasConceptScore W2019977862C3019047270 @default.
• W2019977862 hasConceptScore W2019977862C538909803 @default.
• W2019977862 hasConceptScore W2019977862C55493867 @default.
• W2019977862 hasConceptScore W2019977862C71240020 @default.
• W2019977862 hasIssue "9" @default.
• W2019977862 hasLocation W20199778621 @default.
• W2019977862 hasLocation W20199778622 @default.
• W2019977862 hasOpenAccess W2019977862 @default.
• W2019977862 hasPrimaryLocation W20199778621 @default.
• W2019977862 hasRelatedWork W1769442777 @default.
• W2019977862 hasRelatedWork W1972928594 @default.
• W2019977862 hasRelatedWork W2031168995 @default.
• W2019977862 hasRelatedWork W2040286580 @default.
• W2019977862 hasRelatedWork W2091395663 @default.
• W2019977862 hasRelatedWork W2138971261 @default.
• W2019977862 hasRelatedWork W2160331507 @default.
• W2019977862 hasRelatedWork W2354857368 @default.
• W2019977862 hasRelatedWork W2404917880 @default.

• next