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- W2019978462 abstract "Five independent clones of somatic cell hybrids have been produced by fusing FBU Friend erythroblastic leukemia cells with cells of the pluripotent teratocarcinoma-derived embryonal carcinoma line PCC4azal. All five lines closely resemble their PCC4azal parent. They look like embryonal carcinoma cells by phase contrast and electron microscopy, have high levels of alkaline phosphatase but low levels of acetylcholinesterase, and, like PCC4azal, express both LDH-A and LDH-B. Tumors produced from hybrid lines often contain large amounts of differentiated tissue, including representatives of all three of the classical germ layers. These results suggest that the genome of a pluripotent mammalian cell, far from being unconditionally susceptible to whatever signals differentiated cells employ to maintain their stable phenotype, may itself be able to “reset” the genome of the differentiated cell." @default.
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- W2019978462 title "Teratocarcinoma × friend erythroleukemia cell hybrids resemble their pluripotent embryonal carcinoma parent" @default.
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- W2019978462 doi "https://doi.org/10.1016/0012-1606(77)90159-2" @default.
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