FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019979469> ?p ?o ?g. }

• W2019979469 endingPage "1021" @default.
• W2019979469 startingPage "1009" @default.
• W2019979469 abstract "Identification of Mdm2 and JNK as proteins that target degradation of wt p53 prompted us to examine their effect on mutant p53, which exhibits a prolonged half-life. Of five mutant p53 forms studied for association with the targeting molecules, two no longer bound to Mdm2 and JNK. Three mutant forms, which exhibit high expression levels, showed lower affinity for association with Mdm2 and JNK in concordance with greater affinity to p14(ARF), which is among the stabilizing p53 molecules. Monitoring mutant p53 stability in vitro confirmed that, while certain forms of mutant p53 are no longer affected by either JNK or Mdm2, others are targeted for degradation by JNK/Mdm2, albeit at lower efficiency when compared with wt p53. Expression of wt p53 in tumor cells revealed a short half-life, suggesting that the targeting molecules are functional. Forced expression of mutant p53 in p53 null cells confirmed pattern of association with JNK/Mdm2 and prolonged half-life, as found in the tumor cells. Over-expression of Mdm2 in either tumor (which do express endogenous functional Mdm2) or in p53 null cells decreased the stability of mutant p53 suggesting that, despite its expression, Mdm2/JNK are insufficient (amount/affinity) for targeting mutant p53 degradation. Based on both in vitro and in vivo analyses, we conclude that the prolonged half-life of mutant p53 depends on the nature of the mutation, which either alters association with targeting molecules, ratio between p53 and targeting/stabilizing molecules or targeting efficiency." @default.
• W2019979469 created "2016-06-24" @default.
• W2019979469 creator A5000363681 @default.
• W2019979469 creator A5013600050 @default.
• W2019979469 creator A5023378112 @default.
• W2019979469 creator A5026512599 @default.
• W2019979469 creator A5058032939 @default.
• W2019979469 creator A5067066595 @default.
• W2019979469 creator A5068721624 @default.
• W2019979469 date "2000-01-01" @default.
• W2019979469 modified "2023-10-18" @default.
• W2019979469 title "Analysis of JNK, Mdm2 and p14ARF contribution to the regulation of mutant p53 stability" @default.
• W2019979469 cites W140061535 @default.
• W2019979469 cites W1607766326 @default.
• W2019979469 cites W1959049775 @default.
• W2019979469 cites W1966630774 @default.
• W2019979469 cites W1967203013 @default.
• W2019979469 cites W1967918036 @default.
• W2019979469 cites W1978518304 @default.
• W2019979469 cites W1983751803 @default.
• W2019979469 cites W1991494214 @default.
• W2019979469 cites W1995211857 @default.
• W2019979469 cites W2004723089 @default.
• W2019979469 cites W2015026645 @default.
• W2019979469 cites W2015392890 @default.
• W2019979469 cites W2028871131 @default.
• W2019979469 cites W2028886214 @default.
• W2019979469 cites W2033030646 @default.
• W2019979469 cites W2039382131 @default.
• W2019979469 cites W2039463309 @default.
• W2019979469 cites W2042316019 @default.
• W2019979469 cites W2043912950 @default.
• W2019979469 cites W2043964688 @default.
• W2019979469 cites W2056530510 @default.
• W2019979469 cites W2063877452 @default.
• W2019979469 cites W2081288740 @default.
• W2019979469 cites W2082979850 @default.
• W2019979469 cites W2089574530 @default.
• W2019979469 cites W2100950116 @default.
• W2019979469 cites W2112242228 @default.
• W2019979469 cites W2113070607 @default.
• W2019979469 cites W2132195353 @default.
• W2019979469 cites W2141529421 @default.
• W2019979469 cites W2150097377 @default.
• W2019979469 cites W2150710841 @default.
• W2019979469 cites W2151068510 @default.
• W2019979469 cites W2151160119 @default.
• W2019979469 cites W2169681364 @default.
• W2019979469 cites W2170494099 @default.
• W2019979469 cites W2318053505 @default.
• W2019979469 cites W2335417572 @default.
• W2019979469 cites W4212962560 @default.
• W2019979469 doi "https://doi.org/10.1006/jmbi.1999.3387" @default.
• W2019979469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10656807" @default.
• W2019979469 hasPublicationYear "2000" @default.
• W2019979469 type Work @default.
• W2019979469 sameAs 2019979469 @default.
• W2019979469 citedByCount "38" @default.
• W2019979469 countsByYear W20199794692012 @default.
• W2019979469 countsByYear W20199794692013 @default.
• W2019979469 countsByYear W20199794692014 @default.
• W2019979469 countsByYear W20199794692015 @default.
• W2019979469 countsByYear W20199794692017 @default.
• W2019979469 countsByYear W20199794692018 @default.
• W2019979469 countsByYear W20199794692019 @default.
• W2019979469 countsByYear W20199794692020 @default.
• W2019979469 countsByYear W20199794692021 @default.
• W2019979469 countsByYear W20199794692023 @default.
• W2019979469 crossrefType "journal-article" @default.
• W2019979469 hasAuthorship W2019979469A5000363681 @default.
• W2019979469 hasAuthorship W2019979469A5013600050 @default.
• W2019979469 hasAuthorship W2019979469A5023378112 @default.
• W2019979469 hasAuthorship W2019979469A5026512599 @default.
• W2019979469 hasAuthorship W2019979469A5058032939 @default.
• W2019979469 hasAuthorship W2019979469A5067066595 @default.
• W2019979469 hasAuthorship W2019979469A5068721624 @default.
• W2019979469 hasConcept C104317684 @default.
• W2019979469 hasConcept C143065580 @default.
• W2019979469 hasConcept C153911025 @default.
• W2019979469 hasConcept C190283241 @default.
• W2019979469 hasConcept C202751555 @default.
• W2019979469 hasConcept C207001950 @default.
• W2019979469 hasConcept C207583985 @default.
• W2019979469 hasConcept C2776192174 @default.
• W2019979469 hasConcept C2776750431 @default.
• W2019979469 hasConcept C2778264664 @default.
• W2019979469 hasConcept C54355233 @default.
• W2019979469 hasConcept C55493867 @default.
• W2019979469 hasConcept C555283112 @default.
• W2019979469 hasConcept C86803240 @default.
• W2019979469 hasConcept C95444343 @default.
• W2019979469 hasConceptScore W2019979469C104317684 @default.
• W2019979469 hasConceptScore W2019979469C143065580 @default.
• W2019979469 hasConceptScore W2019979469C153911025 @default.
• W2019979469 hasConceptScore W2019979469C190283241 @default.
• W2019979469 hasConceptScore W2019979469C202751555 @default.
• W2019979469 hasConceptScore W2019979469C207001950 @default.
• W2019979469 hasConceptScore W2019979469C207583985 @default.

• next