Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019980747> ?p ?o ?g. }
- W2019980747 endingPage "427" @default.
- W2019980747 startingPage "414" @default.
- W2019980747 abstract "Down syndrome (DS) is the phenotypic consequence of trisomy 21 and is the most common genetically defined cause of intellectual disability. The most complete, widely available, and well-studied animal model of DS is the Ts65Dn mouse. Recent preclinical successes in rescuing learning and memory deficits in Ts65Dn mice are legitimate causes for optimism that pharmacotherapies for cognitive deficits in DS might be within reach. This article provides a snapshot of potential pharmacotherapies for DS, with emphasis on our recent results showing that the N-methyl-D-aspartate receptor antagonist memantine can reverse learning and memory deficits in Ts65Dn mice. Because memantine has already been approved for the therapy of Alzheimer's dementia, we have been able to very rapidly translate these results into human research and are currently conducting a 16-week, randomized, double-blind, placebo-controlled evaluation of the efficacy, tolerability and safety of memantine hydrochloride on enhancing the cognitive abilities of young adults with DS. The design and current status of this clinical trial will be discussed, which will be followed by some speculation on the potential impact of this and future clinical trials in the field of DS." @default.
- W2019980747 created "2016-06-24" @default.
- W2019980747 creator A5086721650 @default.
- W2019980747 date "2011-01-01" @default.
- W2019980747 modified "2023-10-16" @default.
- W2019980747 title "On the Promise of Pharmacotherapies Targeted at Cognitive and Neurodegenerative Components of Down Syndrome" @default.
- W2019980747 cites W129068659 @default.
- W2019980747 cites W1473628052 @default.
- W2019980747 cites W1497888373 @default.
- W2019980747 cites W1505308024 @default.
- W2019980747 cites W1560980386 @default.
- W2019980747 cites W1565462218 @default.
- W2019980747 cites W1604118788 @default.
- W2019980747 cites W1625776560 @default.
- W2019980747 cites W1900601199 @default.
- W2019980747 cites W1962254068 @default.
- W2019980747 cites W1963956528 @default.
- W2019980747 cites W1966323432 @default.
- W2019980747 cites W1975743085 @default.
- W2019980747 cites W1975890560 @default.
- W2019980747 cites W1978843360 @default.
- W2019980747 cites W1987201296 @default.
- W2019980747 cites W1989353489 @default.
- W2019980747 cites W1992811119 @default.
- W2019980747 cites W1994348124 @default.
- W2019980747 cites W1994573232 @default.
- W2019980747 cites W1997271339 @default.
- W2019980747 cites W1997381668 @default.
- W2019980747 cites W2002902382 @default.
- W2019980747 cites W2003437576 @default.
- W2019980747 cites W2004159036 @default.
- W2019980747 cites W2004596168 @default.
- W2019980747 cites W2010319841 @default.
- W2019980747 cites W2013367712 @default.
- W2019980747 cites W2017791684 @default.
- W2019980747 cites W2021540664 @default.
- W2019980747 cites W2021733070 @default.
- W2019980747 cites W2027795892 @default.
- W2019980747 cites W2030452985 @default.
- W2019980747 cites W2035656084 @default.
- W2019980747 cites W2035923900 @default.
- W2019980747 cites W2036537324 @default.
- W2019980747 cites W2037851765 @default.
- W2019980747 cites W2038401541 @default.
- W2019980747 cites W2039975018 @default.
- W2019980747 cites W2040478347 @default.
- W2019980747 cites W2041303675 @default.
- W2019980747 cites W2045095281 @default.
- W2019980747 cites W2046251419 @default.
- W2019980747 cites W2048119874 @default.
- W2019980747 cites W2049717740 @default.
- W2019980747 cites W2058257681 @default.
- W2019980747 cites W2058723245 @default.
- W2019980747 cites W2060264026 @default.
- W2019980747 cites W2063964767 @default.
- W2019980747 cites W2064739845 @default.
- W2019980747 cites W2067655878 @default.
- W2019980747 cites W2067777223 @default.
- W2019980747 cites W2077273976 @default.
- W2019980747 cites W2079155607 @default.
- W2019980747 cites W2080243540 @default.
- W2019980747 cites W2081646625 @default.
- W2019980747 cites W2082869264 @default.
- W2019980747 cites W2084591564 @default.
- W2019980747 cites W2086398583 @default.
- W2019980747 cites W2087356647 @default.
- W2019980747 cites W2097323692 @default.
- W2019980747 cites W2099265780 @default.
- W2019980747 cites W2101490787 @default.
- W2019980747 cites W2103274980 @default.
- W2019980747 cites W2103709346 @default.
- W2019980747 cites W2109239374 @default.
- W2019980747 cites W2111977586 @default.
- W2019980747 cites W2113291053 @default.
- W2019980747 cites W2114163624 @default.
- W2019980747 cites W2116157944 @default.
- W2019980747 cites W2117396078 @default.
- W2019980747 cites W2122465558 @default.
- W2019980747 cites W2123265074 @default.
- W2019980747 cites W2123299077 @default.
- W2019980747 cites W2124670066 @default.
- W2019980747 cites W2128527424 @default.
- W2019980747 cites W2134198313 @default.
- W2019980747 cites W2136582464 @default.
- W2019980747 cites W2138298735 @default.
- W2019980747 cites W2142723498 @default.
- W2019980747 cites W2144118821 @default.
- W2019980747 cites W2144835441 @default.
- W2019980747 cites W2145543516 @default.
- W2019980747 cites W2148693132 @default.
- W2019980747 cites W2149852014 @default.
- W2019980747 cites W2154768876 @default.
- W2019980747 cites W2156666342 @default.
- W2019980747 cites W2292142163 @default.
- W2019980747 cites W2410991297 @default.
- W2019980747 cites W66130148 @default.
- W2019980747 cites W2781364383 @default.
- W2019980747 cites W95079999 @default.