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• W2019983135 abstract "Objective To assess the extent to which meta-analysis publications of drugs and biologics focus on specific named agents or even only a single agent, and identify characteristics associated with such focus. Study Design and Setting We evaluated 499 articles with meta-analyses published in 2010 and estimated how many did not cover all the available comparisons of tested interventions for a given condition (not all-inclusive); focused on specific named agent(s), or focused strictly on comparisons of only one specific active agent vs. placebo/no treatment or different doses/schedules. Results Of 499 eligible articles, 403 (80.8%) were not all-inclusive, 214 (42.9%) covered only specific named agent(s), and 74 (14.8%) examined only comparisons with one active agent vs. placebo/no treatment or different doses/schedules. Only 39 articles (7.8%) covered all possible indications for the examined agent(s). After adjusting for type of treatment/field, focus on specific named agent(s) was associated with publication in journal venues (odds ratio [OR]: 1.95; 95% confidence interval [CI]: 1.17–3.26) vs. Cochrane, industry sponsoring (OR: 3.94; 95% CI: 1.66–10.66), and individual patient data analyses (OR: 6.59; 95% CI: 2.24–19.39). Individual patient data analyses primarily (29/34) focused on specific named agent(s). Conclusion The scope of meta-analysis publications frequently is narrow and shaped to serve particular agents." @default.
• W2019983135 created "2016-06-24" @default.
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• W2019983135 date "2013-04-01" @default.
• W2019983135 modified "2023-10-03" @default.
• W2019983135 title "Most meta-analyses of drug interventions have narrow scopes and many focus on specific agents" @default.
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• W2019983135 doi "https://doi.org/10.1016/j.jclinepi.2012.10.014" @default.
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