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- W2019983253 abstract "Independent substitution mutations have been detected in capsid polypeptide VP1 of the type 1 oral poliovirus vaccine isolated from normal infant vaccine recipients. These mutations map at amino acid residues 142 and 147 of VP1, a region only minimally hydrophilic. A synthetic peptide, corresponding to residues 141 to 147 of VP1 was synthesized, conjugated to a carrier polypeptide of bovine serum albumin. The conjugate was found to elicit a weak poliovirus neutralizing antibody response. It was also capable of priming the immune system for the production of IgG-type antibodies able to neutralize greater than 99.999% of infectious type 1 virus. It is suggested that region 141 to 147 of VP1 may be involved in neutralization of the virus and that the mutants may have accumulated by antibody selection." @default.
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- W2019983253 date "1985-05-01" @default.
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- W2019983253 title "Natural variants of the sabin type 1 vaccine strain of poliovirus and correlation with a poliovirus neutralization site" @default.
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- W2019983253 doi "https://doi.org/10.1016/0042-6822(85)90121-7" @default.
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