FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019983448> ?p ?o ?g. }

• W2019983448 endingPage "401" @default.
• W2019983448 startingPage "395" @default.
• W2019983448 abstract "To assess whether abnormal responses to an oral glucose load, dyslipidaemia and hyperandrogenaemia, which are commonly found in girls with a history of precocious pubarche, can also be detected in first-degree relatives of these patients.Sixty first-degree relatives (age, 41.4 +/- 4.4 years; BMI, 26.9 +/- 3.3 kg/m2) of girls diagnosed with precocious pubarche were studied. The prevalence of gestational diabetes mellitus and the hirsutism score were assessed in the females. The study was performed during the early follicular phase of the menstrual cycle in females and at random in males.All subjects underwent a standard 75 g 2-h oral glucose tolerance test (OGTT). Serum lipids and lipoproteins were measured in baseline blood samples in all subjects, while serum testosterone, sex hormone-binding globulin (SHBG) levels and the free androgen indices were determined only in females. Impaired glucose tolerance (IGT) and type 2 diabetes mellitus were diagnosed according to the criteria of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus.Seven subjects (11.6%) had type 2 diabetes while a further 14 (23.3%) had IGT; prevalences significantly higher than those reported for the present population of the same age (type 2 diabetes, 2.5% and IGT, 7. 5%; P < 0.001 and P < 0.001, respectively). BMIs were similar in patients with either normal or abnormal glucose tolerance. Abnormal levels of at least two lipid parameters were found in 40% of subjects. Four out of 10 hirsute women and six non-hirsute women reported gestational diabetes. Mean serum SHBG levels were lower in female relatives compared with population controls (P < 0.0005).First-degree relatives of girls with precocious pubarche are at a higher risk of impaired glucose tolerance and type 2 diabetes which, in most cases, is accompanied by an unfavourable lipid profile. Hyperandrogenism and an increased prevalence of gestational diabetes mellitus are frequent among females. These data may prove useful in identifying a specific subset of the population at increased risk of developing metabolic disturbances known to predispose to cardiovascular disease." @default.
• W2019983448 created "2016-06-24" @default.
• W2019983448 creator A5010816868 @default.
• W2019983448 creator A5048780093 @default.
• W2019983448 creator A5075227384 @default.
• W2019983448 creator A5086294942 @default.
• W2019983448 date "1999-10-01" @default.
• W2019983448 modified "2023-10-05" @default.
• W2019983448 title "Increased prevalence of type 2 diabetes mellitus and impaired glucose tolerance in first-degree relatives of girls with a history of precocious pubarche" @default.
• W2019983448 cites W1967584986 @default.
• W2019983448 cites W1969058680 @default.
• W2019983448 cites W1972591544 @default.
• W2019983448 cites W1979337849 @default.
• W2019983448 cites W1986432871 @default.
• W2019983448 cites W1986819260 @default.
• W2019983448 cites W2006263649 @default.
• W2019983448 cites W2010208043 @default.
• W2019983448 cites W2014318859 @default.
• W2019983448 cites W2018972460 @default.
• W2019983448 cites W2024869526 @default.
• W2019983448 cites W2042105780 @default.
• W2019983448 cites W2044970382 @default.
• W2019983448 cites W2062153834 @default.
• W2019983448 cites W2065259932 @default.
• W2019983448 cites W2082999820 @default.
• W2019983448 cites W2084843239 @default.
• W2019983448 cites W2086536613 @default.
• W2019983448 cites W2086664003 @default.
• W2019983448 cites W2100224373 @default.
• W2019983448 cites W2115135831 @default.
• W2019983448 cites W2130964067 @default.
• W2019983448 cites W2147995093 @default.
• W2019983448 cites W2165558549 @default.
• W2019983448 cites W2166391916 @default.
• W2019983448 cites W2313248867 @default.
• W2019983448 cites W2334309509 @default.
• W2019983448 cites W2409816671 @default.
• W2019983448 cites W4233562854 @default.
• W2019983448 cites W4250005844 @default.
• W2019983448 doi "https://doi.org/10.1046/j.1365-2265.1999.00778.x" @default.
• W2019983448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10583304" @default.
• W2019983448 hasPublicationYear "1999" @default.
• W2019983448 type Work @default.
• W2019983448 sameAs 2019983448 @default.
• W2019983448 citedByCount "33" @default.
• W2019983448 countsByYear W20199834482012 @default.
• W2019983448 countsByYear W20199834482013 @default.
• W2019983448 countsByYear W20199834482014 @default.
• W2019983448 countsByYear W20199834482016 @default.
• W2019983448 countsByYear W20199834482020 @default.
• W2019983448 countsByYear W20199834482021 @default.
• W2019983448 crossrefType "journal-article" @default.
• W2019983448 hasAuthorship W2019983448A5010816868 @default.
• W2019983448 hasAuthorship W2019983448A5048780093 @default.
• W2019983448 hasAuthorship W2019983448A5075227384 @default.
• W2019983448 hasAuthorship W2019983448A5086294942 @default.
• W2019983448 hasConcept C126322002 @default.
• W2019983448 hasConcept C134018914 @default.
• W2019983448 hasConcept C2776371013 @default.
• W2019983448 hasConcept C2777180221 @default.
• W2019983448 hasConcept C2777391703 @default.
• W2019983448 hasConcept C2777911890 @default.
• W2019983448 hasConcept C2779234561 @default.
• W2019983448 hasConcept C2779434492 @default.
• W2019983448 hasConcept C2779862289 @default.
• W2019983448 hasConcept C2780609358 @default.
• W2019983448 hasConcept C2780833929 @default.
• W2019983448 hasConcept C2781179581 @default.
• W2019983448 hasConcept C2908647359 @default.
• W2019983448 hasConcept C2910605048 @default.
• W2019983448 hasConcept C30092816 @default.
• W2019983448 hasConcept C3018442814 @default.
• W2019983448 hasConcept C46973012 @default.
• W2019983448 hasConcept C54355233 @default.
• W2019983448 hasConcept C555293320 @default.
• W2019983448 hasConcept C71315377 @default.
• W2019983448 hasConcept C71924100 @default.
• W2019983448 hasConcept C86803240 @default.
• W2019983448 hasConcept C99454951 @default.
• W2019983448 hasConceptScore W2019983448C126322002 @default.
• W2019983448 hasConceptScore W2019983448C134018914 @default.
• W2019983448 hasConceptScore W2019983448C2776371013 @default.
• W2019983448 hasConceptScore W2019983448C2777180221 @default.
• W2019983448 hasConceptScore W2019983448C2777391703 @default.
• W2019983448 hasConceptScore W2019983448C2777911890 @default.
• W2019983448 hasConceptScore W2019983448C2779234561 @default.
• W2019983448 hasConceptScore W2019983448C2779434492 @default.
• W2019983448 hasConceptScore W2019983448C2779862289 @default.
• W2019983448 hasConceptScore W2019983448C2780609358 @default.
• W2019983448 hasConceptScore W2019983448C2780833929 @default.
• W2019983448 hasConceptScore W2019983448C2781179581 @default.
• W2019983448 hasConceptScore W2019983448C2908647359 @default.
• W2019983448 hasConceptScore W2019983448C2910605048 @default.
• W2019983448 hasConceptScore W2019983448C30092816 @default.
• W2019983448 hasConceptScore W2019983448C3018442814 @default.
• W2019983448 hasConceptScore W2019983448C46973012 @default.
• W2019983448 hasConceptScore W2019983448C54355233 @default.
• W2019983448 hasConceptScore W2019983448C555293320 @default.

• next