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• W2019987233 abstract "Abstract Background CD4 + CD25 high regulatory T (T Reg ) cells modulate antigen-specific T cell responses, and can suppress anti-viral immunity. In HTLV-1 infection, a selective decrease in the function of T Reg cell mediated HTLV-1-tax inhibition of FOXP3 expression has been described. The purpose of this study was to assess the frequency and phenotype of T Reg cells in HTLV-1 asymptomatic carriers and in HTLV-1-associated neurological disease (HAM/TSP) patients, and to correlate with measures of T cell activation. Results We were able to confirm that HTLV-I drives activation, spontaneous IFNγ production, and proliferation of CD4+ T cells. We also observed a significantly lower proportion of CTLA-4 + T Reg cells (CD4 + CD25 high T cells) in subjects with HAM/TSP patients compared to healthy controls. Ki-67 expression was negatively correlated to the frequency of CTLA-4 + T Reg cells in HAM/TSP only, although Ki-67 expression was inversely correlated with the percentage of CD127 low T Reg cells in healthy control subjects. Finally, the proportion of CD127 low T Reg cells correlated inversely with HTLV-1 proviral load. Conclusion Taken together, the results suggest that T Reg cells may be subverted in HAM/TSP patients, which could explain the marked cellular activation, spontaneous cytokine production, and proliferation of CD4 + T cells, in particular those expressing the CD25 high CD127 low phenotype. T Reg cells represent a potential target for therapeutic intervention for patients with HTLV-1-related neurological diseases." @default.
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• W2019987233 date "2008-07-29" @default.
• W2019987233 modified "2023-10-16" @default.
• W2019987233 title "The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis" @default.
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• W2019987233 doi "https://doi.org/10.1186/1471-2172-9-41" @default.
• W2019987233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2515103" @default.
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