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• W2019987267 abstract "Chronic myelogenous leukemia is a disease of the pluripotent stem cell that involves the myeloid and, to a varying degree, the lymphoid compartment. We studied the involvement of B cells in chronic myelogenous leukemia at diagnosis and during treatment. B lymphocytes were immortalized by infection with Epstein-Barr virus. B-lymphoid cell lines could be established from 25 patients suffering from Philadelphia-chromosome (Ph1)-positive chronic myelogenous leukemia. The cell lines were tested for expression of the typical 210-kDa fusion protein, p210, using Western-blot analysis, and/or for mRNA expression of bcr-abl fusion genes, using reverse transcriptase polymerase chain reaction analysis. At diagnosis, mosaicism of B cells was demonstrated in every patient. During treatment with interferon alpha, p210-expressing B-lymphoid cell lines could not be established from 8 of 8 patients. Following discontinuation of IFN-α therapy, p210-positive cell lines were found early, even before cytogenetic recurrence. Resistance to IFN-α therapy and progression of the disease were both associated with the appearance of p210-positive cell lines. Cell lines established from 3 healthy individuals and from patients suffering from Ph1-negative diseases did not show p210 expression in Western blots. Our data suggest that B lymphocytes are involved early in the disease, and that B-cell mosaicism may be a sensitive marker for resistance to IFN-α therapy and disease progression. © 1996 Wiley-Liss, Inc." @default.
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• W2019987267 date "1996-11-27" @default.
• W2019987267 modified "2023-09-27" @default.
• W2019987267 title "Mosaicism in BCR-ABL protein expression in B cells in chronic meylogenous leukemia" @default.
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• W2019987267 doi "https://doi.org/10.1002/(sici)1097-0215(19961127)68:5<577::aid-ijc4>3.0.co;2-w" @default.
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