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• W2019987284 abstract "Tetrapyrrole rings possess four nitrogen atoms, two of which act as Bröndsted bases in acidic media. The two protonation steps occur on a close pH range, particularly in the case of meso-tetraphenylporphyrin (TPP) derivatives. If the cause of this phenomenon is well known--a protonation-induced distortion of the porphyrin ring--data on stepwise protonation constants and on electronic absorption spectra of monoprotonated TPPs are sparse. A multivariate approach has been systematically applied to a series of glycoconjugated and hydroxylated TPPs, potential anticancer drugs usable in Photodynamic Therapy. The dual purpose was determination of protonation constants and linking substitution with basicity. Hard-modeling version of MCR-ALS (Multivariate Curve Resolution Alternating Least Squares) has given access to spectra and distribution profile of pure components. Spectra of monoprotonated species (H(3)TPP(+)) in solution resemble those of diprotonated species (H(4)TPP(2+)), mainly differing by a slight blue-shift of bands. Overlap of H(3)TPP(+) and H(4)TPP(2+) spectra reinforces the difficulty to evidence an intermediate form only present in low relative abundance. Depending on macrocycle substitution, pK values ranged from 3.5±0.1 to 5.1±0.1 for the first protonation and from 3.2±0.2 to 4.9±0.1 for the second one. Inner nitrogens' basicity is affected by position, number and nature of peripheral substituents depending on their electrodonating character. pK values have been used to establish a predictive Multiple Linear Regression (MLR) model, relying on atom-type electrotopological indices. This model accurately describes our results and should be applied to new TPP derivatives in a drug-design perspective." @default.
• W2019987284 created "2016-06-24" @default.
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• W2019987284 date "2011-10-01" @default.
• W2019987284 modified "2023-10-14" @default.
• W2019987284 title "Diprotonation process of meso-tetraphenylporphyrin derivatives designed for Photodynamic Therapy of cancers: From Multivariate Curve Resolution to predictive QSPR modeling" @default.
• W2019987284 cites W112873001 @default.
• W2019987284 cites W13076036 @default.
• W2019987284 cites W1565346259 @default.
• W2019987284 cites W1968677584 @default.
• W2019987284 cites W1969285591 @default.
• W2019987284 cites W1969364584 @default.
• W2019987284 cites W1972156862 @default.
• W2019987284 cites W1975959956 @default.
• W2019987284 cites W1978797598 @default.
• W2019987284 cites W1993759752 @default.
• W2019987284 cites W1997197382 @default.
• W2019987284 cites W1997857002 @default.
• W2019987284 cites W2001910387 @default.
• W2019987284 cites W2004334723 @default.
• W2019987284 cites W2010067508 @default.
• W2019987284 cites W2016876507 @default.
• W2019987284 cites W2017671293 @default.
• W2019987284 cites W2020369075 @default.
• W2019987284 cites W2028631054 @default.
• W2019987284 cites W2029745421 @default.
• W2019987284 cites W2030584128 @default.
• W2019987284 cites W2031826118 @default.
• W2019987284 cites W2032953506 @default.
• W2019987284 cites W2033047530 @default.
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• W2019987284 cites W2052080674 @default.
• W2019987284 cites W2053020350 @default.
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• W2019987284 cites W2061825314 @default.
• W2019987284 cites W2063547105 @default.
• W2019987284 cites W2068750303 @default.
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• W2019987284 cites W2121353081 @default.
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• W2019987284 cites W2326504146 @default.
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• W2019987284 doi "https://doi.org/10.1016/j.aca.2011.07.001" @default.
• W2019987284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21962373" @default.
• W2019987284 hasPublicationYear "2011" @default.
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