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• W2019987555 abstract "Abstract 1. The properties of 3,5-di- tert -butyl-4-hydroxybenzylidenemalononitrile (SF 6847) were studied chemically and spectroscopically. Two molecular species of SF6847 were identified: the undissociated form (SFH; ϵ 363 , 10 mM −1 ) and the dissociated form (SF − ; ϵ 454 , 35 mM −1 ). The p K a value of the molecule was determined to be 6.9. 2. On the basis of these properties the interactions of SF6847 with liposomes and valinomycin · K + were studied. The partition constants of SFH ( K n p and SF − ( K − p ) to liposomes were determined separately; K n p was 56 mM −1 and was independent of the pH of the medium, whereas K − p dependend greatly on the pH, being 1.2 mM −1 at pH 7.0 and 2.9 mM −1 at pH 8.0. Using these values, the partition constant of total SF6847 ( K p ) was calculated and found to be essentially the same as that calculated from the kinetics of proton uptake. It was concluded that the amount of SF − bound to liposomes is rate limiting for proton uptake. 3. The effects of membrane potential on partition constants were studied. The K − p decreased greatly upon generation of a membrane potential negative inside the liposomes but increased upon generation of a membrane potential positive inside the liposomes. 4. The interaction of SF6847 with valinomycin in aqueous solution and in liposomes was demonstrated only in the presence of potassium ion. Potassium ion could not be replaced by sodium ion. Evidence was obtained for the formation of the ternary complex valinomycin · K + · SF − in liposomes and in hexane. It was concluded that SF − became more soluble in the liposomal membranes on formation of this ternary complex. All these results support our proposed mechanism for the proton uptake cycle (Yamaguchi, A. and Anraku, Y. (1978) Biochim. Biophys. Acta 501, 136–149)." @default.
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• W2019987555 date "1978-01-01" @default.
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• W2019987555 title "3,5-Di-tert-butyl-4-hydroxybenzylidenemalononitrile. Effects of pH on its binding to liposomes and evidence for formation of a ternary complex with valinomycin and potassium ion" @default.
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• W2019987555 doi "https://doi.org/10.1016/0005-2728(78)90103-2" @default.
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