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- W2019988283 abstract "• Among 140 depressed and control subjects, there were significant positive correlations between indexes of noradrenergic activity in cerebrospinal fluid (CSF), plasma, and urine. Among the depressed patients, CSF levels of the norepinephrine (NE) metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) and urinary outputs of NE and its metabolites normetanephrine, MHPG, and vanillylmandelic acid correlated significantly with plasma cortisol levels in relation to dexamethasone administration. Also, CSF levels of MHPG were significantly higher among patients who were cortisol nonsuppressors than among either patients who were cortisol suppressors or controls. Urinary outputs of NE and normetanephrine were significantly higher among patients who were cortisol nonsuppressors than among controls. Patients who were cortisol suppressors had indexes of NE metabolism similar to those of controls. These results in the depressed patients extend recent observations suggesting that dysregulation of the noradrenergic system and hypothalamic-pituitary-adrenal axis occur together in a subgroup of depressed patients." @default.
- W2019988283 created "2016-06-24" @default.
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- W2019988283 date "1988-09-01" @default.
- W2019988283 modified "2023-10-01" @default.
- W2019988283 title "Norepinephrine and Its Metabolites in Cerebrospinal Fluid, Plasma, and Urine" @default.
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- W2019988283 doi "https://doi.org/10.1001/archpsyc.1988.01800330081010" @default.
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