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• W2019988983 abstract "Study objective To determine the steady-state plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of levofloxacin and ciprofloxacin. Design Multiple-dose, open-label, randomized pharmacokinetic study. Participants Thirty-six healthy, nonsmoking adult subjects were randomized either to oral levofloxacin, 500 or 750 mg once daily for five doses, or ciprofloxacin, 500 mg q12h for nine doses. Interventions: Venipuncture, bronchoscopy, and BAL were performed in each subject at 4 h, 12 h, or 24 h after the last administered dose of antibiotic. Measurement and results Mean plasma concentrations of levofloxacin and ciprofloxacin were similar to those previously reported. For once-daily dosing of levofloxacin, 500 mg, the mean (± SD) steady-state concentrations at 4 h, 12 h, and 24 h in ELF were 9.9 ± 2.7μμ g/mL, 6.5 ± 2.5 μμg/mL, and 0.7 ± 0.4 μμg/mL, respectively; AM concentrations were 97.9 ± 80.0 μμg/mL, 36.7 ± 23.4 μμg/mL, and 13.8 ± 16.0 μμg/mL, respectively. For levofloxacin, 750 mg, the mean steady-state concentrations in ELF were 22.1 ± 14.9 μμg/mL, 9.2 ± 5.3 μμg/mL, and 1.5 ± 0.8 μμg/mL, respectively; AM concentrations were 105.1 ± 65.5 μμg/mL, 36.2 ± 26.1 μμg/mL, and 15.1 ± 2.0 μμg/mL, respectively. The concentrations of ciprofloxacin at 4 h and 12 h in ELF were 1.9 ± 0.9 μμg/mL and 0.4 ± 0.1 μμg/mL, respectively; AM concentrations were 34.9 ± 23.2 μμg/mL and 6.8 ± 5.9 μμg/mL, respectively. The differences in the ELF concentrations of the two levofloxacin groups vs those of the ciprofloxacin group were significant (p < 0.05) at each sampling time. Conclusions Levofloxacin was more extensively distributed into intrapulmonary compartments than ciprofloxacin and achieved significantly higher steady-state concentrations in plasma and ELF during the 24 h after drug administration. To determine the steady-state plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of levofloxacin and ciprofloxacin. Multiple-dose, open-label, randomized pharmacokinetic study. Thirty-six healthy, nonsmoking adult subjects were randomized either to oral levofloxacin, 500 or 750 mg once daily for five doses, or ciprofloxacin, 500 mg q12h for nine doses. Interventions: Venipuncture, bronchoscopy, and BAL were performed in each subject at 4 h, 12 h, or 24 h after the last administered dose of antibiotic. Mean plasma concentrations of levofloxacin and ciprofloxacin were similar to those previously reported. For once-daily dosing of levofloxacin, 500 mg, the mean (± SD) steady-state concentrations at 4 h, 12 h, and 24 h in ELF were 9.9 ± 2.7μμ g/mL, 6.5 ± 2.5 μμg/mL, and 0.7 ± 0.4 μμg/mL, respectively; AM concentrations were 97.9 ± 80.0 μμg/mL, 36.7 ± 23.4 μμg/mL, and 13.8 ± 16.0 μμg/mL, respectively. For levofloxacin, 750 mg, the mean steady-state concentrations in ELF were 22.1 ± 14.9 μμg/mL, 9.2 ± 5.3 μμg/mL, and 1.5 ± 0.8 μμg/mL, respectively; AM concentrations were 105.1 ± 65.5 μμg/mL, 36.2 ± 26.1 μμg/mL, and 15.1 ± 2.0 μμg/mL, respectively. The concentrations of ciprofloxacin at 4 h and 12 h in ELF were 1.9 ± 0.9 μμg/mL and 0.4 ± 0.1 μμg/mL, respectively; AM concentrations were 34.9 ± 23.2 μμg/mL and 6.8 ± 5.9 μμg/mL, respectively. The differences in the ELF concentrations of the two levofloxacin groups vs those of the ciprofloxacin group were significant (p < 0.05) at each sampling time. Levofloxacin was more extensively distributed into intrapulmonary compartments than ciprofloxacin and achieved significantly higher steady-state concentrations in plasma and ELF during the 24 h after drug administration." @default.
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• W2019988983 modified "2023-09-23" @default.
• W2019988983 title "Steady-State Plasma and Intrapulmonary Concentrations of Levofloxacin and Ciprofloxacin in Healthy Adult Subjects" @default.
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• W2019988983 cites W1843993979 @default.
• W2019988983 cites W1963737703 @default.
• W2019988983 cites W1978395933 @default.
• W2019988983 cites W1983076976 @default.
• W2019988983 cites W1988076133 @default.
• W2019988983 cites W1993515016 @default.
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• W2019988983 cites W2071791143 @default.
• W2019988983 cites W2073595001 @default.
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• W2019988983 cites W2090145948 @default.
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• W2019988983 cites W2112168572 @default.
• W2019988983 cites W2112302527 @default.
• W2019988983 cites W2113717321 @default.
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• W2019988983 cites W2129531532 @default.
• W2019988983 cites W2131339429 @default.
• W2019988983 cites W2132279294 @default.
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• W2019988983 cites W2157156997 @default.
• W2019988983 cites W2163546048 @default.
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• W2019988983 doi "https://doi.org/10.1378/chest.119.4.1114" @default.
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