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- W2019989138 abstract "The lower jaws of archaeal RNA polymerase and eukaryotic RNA polymerase II include orthologous subunits H and Rpb5, respectively. The tertiary structure of H is very similar to the structure of the C-terminal domain of Rpb5, and both subunits are proximal to downstream DNA in pre-initiation complexes. Analyses of reconstituted euryarchaeal polymerase lacking subunit H revealed that H is important for open complex formation and initial transcription. Eukaryotic Rpb5 rescues activity of the ΔH enzyme indicating a strong conservation of function for this subunit from archaea to eukaryotes. Photochemical cross-linking in elongation complexes revealed a striking structural rearrangement of RNA polymerase, bringing subunit H near the transcribed DNA strand one helical turn downstream of the active center, in contrast to the positioning observed in preinitiation complexes. The rearrangement of subunits H and A′′ suggest a major conformational change in the archaeal RNAP lower jaw upon formation of the elongation complex." @default.
- W2019989138 created "2016-06-24" @default.
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- W2019989138 date "2009-12-29" @default.
- W2019989138 modified "2023-09-27" @default.
- W2019989138 title "Rearrangement of the RNA polymerase subunit H and the lower jaw in archaeal elongation complexes" @default.
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- W2019989138 doi "https://doi.org/10.1093/nar/gkp1190" @default.
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