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- W2019989477 abstract "Estrogen-related receptor gamma (ERRgamma) is an orphan nuclear receptor highly expressed in heart, skeletal muscle, kidney, and brain. To identify activation function-1 (AF-1)-dependent cofactors involved in the transcriptional function of ERRgamma, we screened for human cDNAs coding for proteins that bind to the bacterial expressed AF-1 by biopanning of a phage display library. Phages displaying fusion proteins with full-length PNRC2 (proline-rich nuclear receptor co-regulatory protein 2), already shown to be a cofactor for other nuclear receptors, and with a polypeptide of the bHLH corepressor TLE1 bound to the AF-1 containing bait. Pull-down analyses demonstrated a direct interaction of the receptor with the newly identified full-length proteins. Surprisingly, not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis." @default.
- W2019989477 created "2016-06-24" @default.
- W2019989477 creator A5031967351 @default.
- W2019989477 creator A5040935455 @default.
- W2019989477 date "2003-12-01" @default.
- W2019989477 modified "2023-10-17" @default.
- W2019989477 title "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRγ" @default.
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- W2019989477 doi "https://doi.org/10.1016/j.bbrc.2003.11.025" @default.
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