FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019992167> ?p ?o ?g. }

• W2019992167 endingPage "163" @default.
• W2019992167 startingPage "151" @default.
• W2019992167 abstract "Bacterial infection decreases skeletal muscle protein synthesis via inhibition of the mammalian target of rapamycin (mTOR), a key regulator of translation initiation. To better define the mechanism by which muscle mTOR activity is decreased, we used an in vitro model of C2C12 myotubes treated with endotoxin [lipopolysaccharide (LPS)]and interferon (IFN)-γ to determine whether stable lipophilic pyruvate derivatives restore mTOR signaling. Myotubes treated with a combination of LPS and IFNγ down-regulated the phosphorylation of the mTOR substrates S6 kinase-1 and 4E binding protein-1. The phosphorylation of ribosomal protein S6 was decreased, whereas phosphorylation of elongation factor-2 was enhanced; all results consistent with defects in both translation initiation and elongation. LPS/IFNγ decreased protein synthesis 60% in myotubes. Treatment with methyl or ethyl pyruvate partially protected against the LPS/IFNγ-induced fall in mTOR signaling. The protective effect of ethyl and methyl pyruvate could not be replicated by an equimolar amount of sodium pyruvate. Although LPS/IFNγ treated myotubes were initially IGF-I responsive, prolonged exposure (≥ 17 h) resulted in IGF-I resistance at the level of mTOR despite normal IGF-I receptor phosphorylation. Ethyl pyruvate treatment restored IGF-I sensitivity as evidenced by the left shift in the IGF-I dose-response curve and maintained IGF-I responsiveness for a prolonged period of time. Ethyl pyruvate also restored IGF-I-stimulated protein synthesis in LPS/IFNγ-treated myotubes. Cotreatment with N-acetyl cysteine or ascorbic acid also preserved IGF-I sensitivity and mTOR activity. The data suggest that the combination of LPS and IFNγ inhibits mTOR activity and that prolonged exposure induces IGF-I resistance in myotubes. Lipophilic pyruvate derivatives and antioxidants show promise at rescuing mTOR activity and muscle protein synthesis by maintaining IGF-I sensitivity in this model." @default.
• W2019992167 created "2016-06-24" @default.
• W2019992167 creator A5048378734 @default.
• W2019992167 creator A5073807348 @default.
• W2019992167 creator A5075935670 @default.
• W2019992167 date "2011-01-01" @default.
• W2019992167 modified "2023-09-24" @default.
• W2019992167 title "Ethyl Pyruvate Preserves IGF-I Sensitivity toward mTOR Substrates and Protein Synthesis in C2C12 Myotubes" @default.
• W2019992167 cites W1572936019 @default.
• W2019992167 cites W1586159393 @default.
• W2019992167 cites W1970707895 @default.
• W2019992167 cites W1974137661 @default.
• W2019992167 cites W1974265855 @default.
• W2019992167 cites W1978541724 @default.
• W2019992167 cites W1980424395 @default.
• W2019992167 cites W1983112008 @default.
• W2019992167 cites W1983379130 @default.
• W2019992167 cites W1983698019 @default.
• W2019992167 cites W1989186349 @default.
• W2019992167 cites W1995600689 @default.
• W2019992167 cites W1999999605 @default.
• W2019992167 cites W2002031023 @default.
• W2019992167 cites W2002914227 @default.
• W2019992167 cites W2004582874 @default.
• W2019992167 cites W2007539521 @default.
• W2019992167 cites W2007924904 @default.
• W2019992167 cites W2009313095 @default.
• W2019992167 cites W2021315826 @default.
• W2019992167 cites W2025176940 @default.
• W2019992167 cites W2026784725 @default.
• W2019992167 cites W2027012830 @default.
• W2019992167 cites W2027785297 @default.
• W2019992167 cites W2035137991 @default.
• W2019992167 cites W2037381188 @default.
• W2019992167 cites W2040761340 @default.
• W2019992167 cites W2041308494 @default.
• W2019992167 cites W2044748770 @default.
• W2019992167 cites W2057077852 @default.
• W2019992167 cites W2058152973 @default.
• W2019992167 cites W2060818930 @default.
• W2019992167 cites W2060905299 @default.
• W2019992167 cites W2061873998 @default.
• W2019992167 cites W2066670686 @default.
• W2019992167 cites W2070083063 @default.
• W2019992167 cites W2078071611 @default.
• W2019992167 cites W2082987747 @default.
• W2019992167 cites W2096325355 @default.
• W2019992167 cites W2103180230 @default.
• W2019992167 cites W2105981385 @default.
• W2019992167 cites W2107366065 @default.
• W2019992167 cites W2112620654 @default.
• W2019992167 cites W2113529945 @default.
• W2019992167 cites W2117028091 @default.
• W2019992167 cites W2124817377 @default.
• W2019992167 cites W2128236448 @default.
• W2019992167 cites W2151117040 @default.
• W2019992167 cites W2160079255 @default.
• W2019992167 cites W2160551502 @default.
• W2019992167 cites W2161204293 @default.
• W2019992167 cites W2165543647 @default.
• W2019992167 cites W2166979725 @default.
• W2019992167 cites W2256763537 @default.
• W2019992167 cites W2340126464 @default.
• W2019992167 cites W4244787432 @default.
• W2019992167 doi "https://doi.org/10.1210/en.2010-0248" @default.
• W2019992167 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3219047" @default.
• W2019992167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21106878" @default.
• W2019992167 hasPublicationYear "2011" @default.
• W2019992167 type Work @default.
• W2019992167 sameAs 2019992167 @default.
• W2019992167 citedByCount "11" @default.
• W2019992167 countsByYear W20199921672012 @default.
• W2019992167 countsByYear W20199921672014 @default.
• W2019992167 countsByYear W20199921672015 @default.
• W2019992167 countsByYear W20199921672020 @default.
• W2019992167 countsByYear W20199921672021 @default.
• W2019992167 countsByYear W20199921672022 @default.
• W2019992167 crossrefType "journal-article" @default.
• W2019992167 hasAuthorship W2019992167A5048378734 @default.
• W2019992167 hasAuthorship W2019992167A5073807348 @default.
• W2019992167 hasAuthorship W2019992167A5075935670 @default.
• W2019992167 hasBestOaLocation W20199921671 @default.
• W2019992167 hasConcept C11960822 @default.
• W2019992167 hasConcept C126322002 @default.
• W2019992167 hasConcept C134018914 @default.
• W2019992167 hasConcept C185592680 @default.
• W2019992167 hasConcept C2779959927 @default.
• W2019992167 hasConcept C2780926556 @default.
• W2019992167 hasConcept C3763915 @default.
• W2019992167 hasConcept C55493867 @default.
• W2019992167 hasConcept C62478195 @default.
• W2019992167 hasConcept C71924100 @default.
• W2019992167 hasConcept C86554907 @default.
• W2019992167 hasConcept C86803240 @default.
• W2019992167 hasConcept C87325107 @default.
• W2019992167 hasConcept C97029542 @default.
• W2019992167 hasConceptScore W2019992167C11960822 @default.
• W2019992167 hasConceptScore W2019992167C126322002 @default.

• next