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- W2019993996 abstract "Glucose-induced insulin secretion by pancreatic β-cells is generally schematized by a ‘consensus model’ that involves the following sequence of events: acceleration of glucose metabolism, closure of ATP-sensitive potassium channels (KATP channels) in the plasma membrane, depolarization, influx of Ca2+ through voltage-dependent calcium channels and a rise in cytosolic-free Ca2+ concentration that induces exocytosis of insulin-containing granules. This model adequately depicts the essential triggering pathway but is incomplete. In this article, we first make a case for a model of dual regulation in which a metabolic amplifying pathway is also activated by glucose and augments the secretory response to the triggering Ca2+ signal under physiological conditions. We next discuss experimental evidence, largely but not exclusively obtained from β-cells lacking KATP channels, which indicates that these channels are not the only possible transducers of glucose effects on the triggering Ca2+signal. We finally address the identity of the widely neglected background inward current (Cl− efflux vs. Na+ or Ca2+ influx through voltage-independent channels) that is necessary to cause β-cell depolarization when glucose closes KATP channels. More attention should be paid to the possibility that some components of this background current are influenced by glucose metabolism and have their place in a model of glucose-induced insulin secretion." @default.
- W2019993996 created "2016-06-24" @default.
- W2019993996 creator A5050215643 @default.
- W2019993996 creator A5061292952 @default.
- W2019993996 creator A5076977607 @default.
- W2019993996 creator A5079310385 @default.
- W2019993996 date "2009-11-01" @default.
- W2019993996 modified "2023-10-14" @default.
- W2019993996 title "Shortcomings of current models of glucose-induced insulin secretion" @default.
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- W2019993996 doi "https://doi.org/10.1111/j.1463-1326.2009.01109.x" @default.
- W2019993996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19817799" @default.
- W2019993996 hasPublicationYear "2009" @default.
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