Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019995331> ?p ?o ?g. }
- W2019995331 endingPage "229" @default.
- W2019995331 startingPage "222" @default.
- W2019995331 abstract "This paper presents an aptameric graphene nanosensor for detection of small-molecule biomarkers. To address difficulties in direct detection of small molecules associated with their low molecular weight and electrical charge, we incorporate an aptamer-based competitive affinity assay in a graphene field effect transistor (FET), and demonstrate the utility of the nanosensor with dehydroepiandrosterone sulfate (DHEA-S), a small-molecule steroid hormone, as the target analyte. In the competitive affinity assay, DHEA-S specifically binds to aptamer molecules pre-hybridized to their complementary DNA anchor molecules immobilized on the graphene surface. This results in the competitive release of the strongly charged aptamer from the DNA anchor and hence a change in electrical properties of the graphene, which can be measured to achieve the detection of DHEA-S. We present experimental data on the label-free, specific and quantitative detection of DHEA-S at clinically appropriate concentrations with an estimated detection limit of 44.7 nM, and analyze the trend observed in the experiments using molecular binding kinetics theory. These results demonstrate the potential of our nanosensor in the detection of DHEA-S and other small molecules in biomedical applications." @default.
- W2019995331 created "2016-06-24" @default.
- W2019995331 creator A5001091970 @default.
- W2019995331 creator A5005558019 @default.
- W2019995331 creator A5007197576 @default.
- W2019995331 creator A5007637381 @default.
- W2019995331 creator A5030814682 @default.
- W2019995331 creator A5038766727 @default.
- W2019995331 creator A5040467332 @default.
- W2019995331 creator A5048248377 @default.
- W2019995331 creator A5049694358 @default.
- W2019995331 creator A5072191827 @default.
- W2019995331 creator A5084336844 @default.
- W2019995331 creator A5089286262 @default.
- W2019995331 date "2015-09-01" @default.
- W2019995331 modified "2023-10-02" @default.
- W2019995331 title "An aptameric graphene nanosensor for label-free detection of small-molecule biomarkers" @default.
- W2019995331 cites W1966837020 @default.
- W2019995331 cites W1969146501 @default.
- W2019995331 cites W1976330752 @default.
- W2019995331 cites W1980210292 @default.
- W2019995331 cites W1986568472 @default.
- W2019995331 cites W1992086000 @default.
- W2019995331 cites W1997686479 @default.
- W2019995331 cites W1999201994 @default.
- W2019995331 cites W2004158382 @default.
- W2019995331 cites W2006478550 @default.
- W2019995331 cites W2010971702 @default.
- W2019995331 cites W2023711677 @default.
- W2019995331 cites W2026167865 @default.
- W2019995331 cites W2034047007 @default.
- W2019995331 cites W2039211361 @default.
- W2019995331 cites W2043177279 @default.
- W2019995331 cites W2046928039 @default.
- W2019995331 cites W2050491993 @default.
- W2019995331 cites W2050949319 @default.
- W2019995331 cites W2056404648 @default.
- W2019995331 cites W2058122340 @default.
- W2019995331 cites W2063583164 @default.
- W2019995331 cites W2064602503 @default.
- W2019995331 cites W2065569575 @default.
- W2019995331 cites W2065599687 @default.
- W2019995331 cites W2065610841 @default.
- W2019995331 cites W2072883456 @default.
- W2019995331 cites W2074306150 @default.
- W2019995331 cites W2088321686 @default.
- W2019995331 cites W2091882022 @default.
- W2019995331 cites W2097721457 @default.
- W2019995331 cites W2105997650 @default.
- W2019995331 cites W2108102346 @default.
- W2019995331 cites W2108603981 @default.
- W2019995331 cites W2110774563 @default.
- W2019995331 cites W2121621337 @default.
- W2019995331 cites W2122693364 @default.
- W2019995331 cites W2123631149 @default.
- W2019995331 cites W2125284466 @default.
- W2019995331 cites W2126072473 @default.
- W2019995331 cites W2127159287 @default.
- W2019995331 cites W2134233006 @default.
- W2019995331 cites W2140782011 @default.
- W2019995331 cites W2147290521 @default.
- W2019995331 cites W2153324340 @default.
- W2019995331 cites W2169876926 @default.
- W2019995331 cites W2529230938 @default.
- W2019995331 cites W4238768337 @default.
- W2019995331 doi "https://doi.org/10.1016/j.bios.2015.04.025" @default.
- W2019995331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4466219" @default.
- W2019995331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25912678" @default.
- W2019995331 hasPublicationYear "2015" @default.
- W2019995331 type Work @default.
- W2019995331 sameAs 2019995331 @default.
- W2019995331 citedByCount "48" @default.
- W2019995331 countsByYear W20199953312015 @default.
- W2019995331 countsByYear W20199953312016 @default.
- W2019995331 countsByYear W20199953312017 @default.
- W2019995331 countsByYear W20199953312018 @default.
- W2019995331 countsByYear W20199953312019 @default.
- W2019995331 countsByYear W20199953312020 @default.
- W2019995331 countsByYear W20199953312021 @default.
- W2019995331 countsByYear W20199953312022 @default.
- W2019995331 countsByYear W20199953312023 @default.
- W2019995331 crossrefType "journal-article" @default.
- W2019995331 hasAuthorship W2019995331A5001091970 @default.
- W2019995331 hasAuthorship W2019995331A5005558019 @default.
- W2019995331 hasAuthorship W2019995331A5007197576 @default.
- W2019995331 hasAuthorship W2019995331A5007637381 @default.
- W2019995331 hasAuthorship W2019995331A5030814682 @default.
- W2019995331 hasAuthorship W2019995331A5038766727 @default.
- W2019995331 hasAuthorship W2019995331A5040467332 @default.
- W2019995331 hasAuthorship W2019995331A5048248377 @default.
- W2019995331 hasAuthorship W2019995331A5049694358 @default.
- W2019995331 hasAuthorship W2019995331A5072191827 @default.
- W2019995331 hasAuthorship W2019995331A5084336844 @default.
- W2019995331 hasAuthorship W2019995331A5089286262 @default.
- W2019995331 hasBestOaLocation W20199953312 @default.
- W2019995331 hasConcept C10390740 @default.
- W2019995331 hasConcept C119128265 @default.
- W2019995331 hasConcept C12554922 @default.