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• W2019995772 abstract "In neurons, synaptic vesicle exocytosis involves the formation of a core complex particle including syntaxin‐1, synaptosomal‐associated protein of 25 kDa (SNAP‐25) and vesicle‐associated membrane protein (VAMP)‐2/synaptobrevin. The expression of these proteins was investigated in a panel of cell lines, including lines of endocrine and intestinal origin, by Western blotting and/or immunocytochemistry. The three core complex proteins were detected in the enteroendocrine, cholecystokinin (CCK)‐secreting, cell lines STC‐1 and GLUTag, and in the endocrine non‐intestinal cell lines CA‐77 and HIT‐T15. In contrast, SNAP‐25 and syntaxin‐1 were undetected in the intestinal non‐endocrine cell lines IEC‐6, HT‐29 and Caco‐2, whereas a slight expression of VAMP‐2 was documented in IEC‐6 and HT‐29 cells. Co‐immunoprecipitation experiments indicated that syntaxin‐1, SNAP‐25 and VAMP‐2 were present in a complex similar to that identified in brain. In the STC‐1 cell line, treatment of streptolysin‐O‐permeabilized cells with tetanus toxin (Tetx) selectively cleaved VAMP‐2 and VAMP‐3/cellubrevin, and simultaneously abolished Ca 2+ ‐induced CCK secretion (IC 50 ∼12 nM). These results show that endocrine cell lines of intestinal origin express syntaxin‐1, SNAP‐25 and VAMP‐2, and suggest a key role for a Tetx‐sensitive protein (for example VAMP‐2 and/or VAMP‐3) in the CCK secretion by STC‐1 cells." @default.
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• W2019995772 date "1998-03-20" @default.
• W2019995772 modified "2023-10-18" @default.
• W2019995772 title "Expression of SNARE proteins in enteroendocrine cell lines and functional role of tetanus toxin-sensitive proteins in cholecystokinin release" @default.
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• W2019995772 doi "https://doi.org/10.1016/s0014-5793(98)00209-9" @default.
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