FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019997116> ?p ?o ?g. }

• W2019997116 endingPage "697" @default.
• W2019997116 startingPage "686" @default.
• W2019997116 abstract "Clinical criteria, primarily young age of cancer onset and family history of signature cancers, have been developed to identify individuals at elevated risk for Lynch syndrome with the goals of early identification and cancer prevention. In 2007, the Society of Gynecologic Oncology (SGO)-codified criteria for women presenting with gynecologic cancers. These criteria have not been validated in a population-based setting. For 412 unselected endometrial cancers, immunohistochemical expression of DNA mismatch repair proteins and MLH1 methylation were assessed to classify tumors as sporadic or probable Lynch syndrome (PLS). In this cohort, 10.5% of patients were designated as PLS based on tumor testing. The sensitivity and specificity of the SGO criteria to identify these same cases were 32.6% [95% confidence interval (CI), 19.2-48.5] and 77% (95% CI, 72.7-81.8), respectively. With the exception of tumor location in the lower uterine segment, multivariate analysis of clinical features, family history, and pathologic variables failed to identify significant differences between the sporadic and PLS groups. A simplified cost-effectiveness analysis demonstrated that the SGO clinical criteria and universal tissue testing strategies had comparable costs per patient with PLS identified. In conclusion, the SGO criteria successfully identify PLS cases among women with endometrial cancer who are young or have significant family history of signature tumors. However, a larger proportion of patients with PLS who are older and have less significant family history are not detected by this screening strategy. Universal tissue testing may be necessary to capture more individuals at risk for having Lynch syndrome." @default.
• W2019997116 created "2016-06-24" @default.
• W2019997116 creator A5019073901 @default.
• W2019997116 creator A5045124719 @default.
• W2019997116 creator A5059484239 @default.
• W2019997116 creator A5064180079 @default.
• W2019997116 creator A5073079562 @default.
• W2019997116 creator A5076583827 @default.
• W2019997116 creator A5078692182 @default.
• W2019997116 creator A5080656521 @default.
• W2019997116 creator A5084420925 @default.
• W2019997116 creator A5088938634 @default.
• W2019997116 date "2014-07-01" @default.
• W2019997116 modified "2023-09-26" @default.
• W2019997116 title "Evaluation of Clinical Criteria for the Identification of Lynch Syndrome among Unselected Patients with Endometrial Cancer" @default.
• W2019997116 cites W1893792948 @default.
• W2019997116 cites W1967576773 @default.
• W2019997116 cites W1967725159 @default.
• W2019997116 cites W1970415574 @default.
• W2019997116 cites W1971116157 @default.
• W2019997116 cites W1981489996 @default.
• W2019997116 cites W1984037401 @default.
• W2019997116 cites W1985498917 @default.
• W2019997116 cites W1997706585 @default.
• W2019997116 cites W2004036465 @default.
• W2019997116 cites W2006677829 @default.
• W2019997116 cites W2020498036 @default.
• W2019997116 cites W2024346369 @default.
• W2019997116 cites W2037342915 @default.
• W2019997116 cites W2042885655 @default.
• W2019997116 cites W2047041699 @default.
• W2019997116 cites W2062716963 @default.
• W2019997116 cites W2066833606 @default.
• W2019997116 cites W2074691031 @default.
• W2019997116 cites W2081680846 @default.
• W2019997116 cites W2081993522 @default.
• W2019997116 cites W2083337813 @default.
• W2019997116 cites W2088188938 @default.
• W2019997116 cites W2101810235 @default.
• W2019997116 cites W2103848163 @default.
• W2019997116 cites W2110883720 @default.
• W2019997116 cites W2111404268 @default.
• W2019997116 cites W2112237372 @default.
• W2019997116 cites W2112565258 @default.
• W2019997116 cites W2122675147 @default.
• W2019997116 cites W2136225311 @default.
• W2019997116 cites W2137098494 @default.
• W2019997116 cites W2139015332 @default.
• W2019997116 cites W2141930394 @default.
• W2019997116 cites W2146263344 @default.
• W2019997116 cites W2159899668 @default.
• W2019997116 cites W2165736459 @default.
• W2019997116 cites W2170554644 @default.
• W2019997116 cites W2188312187 @default.
• W2019997116 cites W2315998729 @default.
• W2019997116 cites W4233647878 @default.
• W2019997116 doi "https://doi.org/10.1158/1940-6207.capr-13-0359" @default.
• W2019997116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4090057" @default.
• W2019997116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24771847" @default.
• W2019997116 hasPublicationYear "2014" @default.
• W2019997116 type Work @default.
• W2019997116 sameAs 2019997116 @default.
• W2019997116 citedByCount "40" @default.
• W2019997116 countsByYear W20199971162014 @default.
• W2019997116 countsByYear W20199971162015 @default.
• W2019997116 countsByYear W20199971162016 @default.
• W2019997116 countsByYear W20199971162017 @default.
• W2019997116 countsByYear W20199971162018 @default.
• W2019997116 countsByYear W20199971162019 @default.
• W2019997116 countsByYear W20199971162020 @default.
• W2019997116 countsByYear W20199971162021 @default.
• W2019997116 countsByYear W20199971162022 @default.
• W2019997116 countsByYear W20199971162023 @default.
• W2019997116 crossrefType "journal-article" @default.
• W2019997116 hasAuthorship W2019997116A5019073901 @default.
• W2019997116 hasAuthorship W2019997116A5045124719 @default.
• W2019997116 hasAuthorship W2019997116A5059484239 @default.
• W2019997116 hasAuthorship W2019997116A5064180079 @default.
• W2019997116 hasAuthorship W2019997116A5073079562 @default.
• W2019997116 hasAuthorship W2019997116A5076583827 @default.
• W2019997116 hasAuthorship W2019997116A5078692182 @default.
• W2019997116 hasAuthorship W2019997116A5080656521 @default.
• W2019997116 hasAuthorship W2019997116A5084420925 @default.
• W2019997116 hasAuthorship W2019997116A5088938634 @default.
• W2019997116 hasBestOaLocation W20199971161 @default.
• W2019997116 hasConcept C111425858 @default.
• W2019997116 hasConcept C121608353 @default.
• W2019997116 hasConcept C126322002 @default.
• W2019997116 hasConcept C143998085 @default.
• W2019997116 hasConcept C2776559941 @default.
• W2019997116 hasConcept C2777088508 @default.
• W2019997116 hasConcept C2781179581 @default.
• W2019997116 hasConcept C2908647359 @default.
• W2019997116 hasConcept C29456083 @default.
• W2019997116 hasConcept C44249647 @default.
• W2019997116 hasConcept C526805850 @default.
• W2019997116 hasConcept C60748783 @default.
• W2019997116 hasConcept C71924100 @default.

• next