FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019998199> ?p ?o ?g. }

• W2019998199 endingPage "279" @default.
• W2019998199 startingPage "265" @default.
• W2019998199 abstract "The performance of dry powder aerosol delivery systems depends not only on the powder formulation but also on the dry powder inhalers (DPIs). Effects of turbulence, grid, mouthpiece, inlet size, air flow, and capsule on the DPIs performance have been investigated previously. Considering powder dispersion in DPIs is a time-dependent process, the powder residence time in DPIs is supposed to have a great impact on DPIs efficiency. This study sought to investigate the effect of powder residence time on the performance of a commercial DPI Aerolizer(®).A standard Aerolizer(®) (SD) and five modified devices (MD1, MD2, MD3, MD4, and MD5) were employed for this research. Computational fluid dynamics analysis was used to calculate the flow field and the powder residence time in these devices. Recombinant human interleukin-2 inhalation powders and a twin impinger were used for the deposition experiment.The powder mean residence time in the secondary atomization zone of the devices was increased from 0 ms for SD to 0.33, 0.96, 1.42, 1.76, and 2.14 ms for MD1, MD2, MD3, MD4, and MD5, respectively. At a flow rate of 60 L/min, with an increase in the powder residence time in these devices, a significant gradual and increasing trend in the powder respirable fraction was observed from 29.1%± 1.1% (MD1) to 32.6% ± 2.2% (MD2), 37.1% ± 1.1% (MD3), and 43.7% ± 2.1% (MD4). There was no significant difference in the powder respirable fraction between SD and MD1 or between MD4 and MD5.Within a certain range, increasing the powder residence time could improve the performance of Aerolizer(®) by increasing the powder-air interaction time (the main reason) and increasing the powder-device compaction (the secondary reason). Combination of high turbulence level and sufficient powder residence time could further improve the device performance." @default.
• W2019998199 created "2016-06-24" @default.
• W2019998199 creator A5027471961 @default.
• W2019998199 creator A5054352397 @default.
• W2019998199 creator A5058732442 @default.
• W2019998199 creator A5060998288 @default.
• W2019998199 creator A5068611651 @default.
• W2019998199 creator A5090099469 @default.
• W2019998199 date "2012-10-01" @default.
• W2019998199 modified "2023-09-27" @default.
• W2019998199 title "Importance of Powder Residence Time for the Aerosol Delivery Performance of a Commercial Dry Powder Inhaler Aerolizer^®" @default.
• W2019998199 cites W1963900947 @default.
• W2019998199 cites W1969619918 @default.
• W2019998199 cites W1989311165 @default.
• W2019998199 cites W1991310381 @default.
• W2019998199 cites W2002594100 @default.
• W2019998199 cites W2004049688 @default.
• W2019998199 cites W2005496825 @default.
• W2019998199 cites W2007050728 @default.
• W2019998199 cites W2011884940 @default.
• W2019998199 cites W2018227496 @default.
• W2019998199 cites W2018538065 @default.
• W2019998199 cites W2030406119 @default.
• W2019998199 cites W2033872754 @default.
• W2019998199 cites W2035911015 @default.
• W2019998199 cites W2040593024 @default.
• W2019998199 cites W2041112691 @default.
• W2019998199 cites W2055013037 @default.
• W2019998199 cites W2056301226 @default.
• W2019998199 cites W2057688309 @default.
• W2019998199 cites W2066265315 @default.
• W2019998199 cites W2079786079 @default.
• W2019998199 cites W2086224770 @default.
• W2019998199 cites W2117367996 @default.
• W2019998199 cites W2152386842 @default.
• W2019998199 cites W2157365457 @default.
• W2019998199 cites W2158768278 @default.
• W2019998199 cites W3116432315 @default.
• W2019998199 doi "https://doi.org/10.1089/jamp.2011.0908" @default.
• W2019998199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22280548" @default.
• W2019998199 hasPublicationYear "2012" @default.
• W2019998199 type Work @default.
• W2019998199 sameAs 2019998199 @default.
• W2019998199 citedByCount "14" @default.
• W2019998199 countsByYear W20199981992013 @default.
• W2019998199 countsByYear W20199981992014 @default.
• W2019998199 countsByYear W20199981992015 @default.
• W2019998199 countsByYear W20199981992016 @default.
• W2019998199 countsByYear W20199981992018 @default.
• W2019998199 countsByYear W20199981992021 @default.
• W2019998199 countsByYear W20199981992022 @default.
• W2019998199 crossrefType "journal-article" @default.
• W2019998199 hasAuthorship W2019998199A5027471961 @default.
• W2019998199 hasAuthorship W2019998199A5054352397 @default.
• W2019998199 hasAuthorship W2019998199A5058732442 @default.
• W2019998199 hasAuthorship W2019998199A5060998288 @default.
• W2019998199 hasAuthorship W2019998199A5068611651 @default.
• W2019998199 hasAuthorship W2019998199A5090099469 @default.
• W2019998199 hasConcept C126322002 @default.
• W2019998199 hasConcept C127413603 @default.
• W2019998199 hasConcept C178790620 @default.
• W2019998199 hasConcept C185592680 @default.
• W2019998199 hasConcept C187320778 @default.
• W2019998199 hasConcept C192562407 @default.
• W2019998199 hasConcept C199343813 @default.
• W2019998199 hasConcept C2775913793 @default.
• W2019998199 hasConcept C2776042228 @default.
• W2019998199 hasConcept C2777419714 @default.
• W2019998199 hasConcept C2779345167 @default.
• W2019998199 hasConcept C2780261241 @default.
• W2019998199 hasConcept C2780955776 @default.
• W2019998199 hasConcept C71924100 @default.
• W2019998199 hasConceptScore W2019998199C126322002 @default.
• W2019998199 hasConceptScore W2019998199C127413603 @default.
• W2019998199 hasConceptScore W2019998199C178790620 @default.
• W2019998199 hasConceptScore W2019998199C185592680 @default.
• W2019998199 hasConceptScore W2019998199C187320778 @default.
• W2019998199 hasConceptScore W2019998199C192562407 @default.
• W2019998199 hasConceptScore W2019998199C199343813 @default.
• W2019998199 hasConceptScore W2019998199C2775913793 @default.
• W2019998199 hasConceptScore W2019998199C2776042228 @default.
• W2019998199 hasConceptScore W2019998199C2777419714 @default.
• W2019998199 hasConceptScore W2019998199C2779345167 @default.
• W2019998199 hasConceptScore W2019998199C2780261241 @default.
• W2019998199 hasConceptScore W2019998199C2780955776 @default.
• W2019998199 hasConceptScore W2019998199C71924100 @default.
• W2019998199 hasIssue "5" @default.
• W2019998199 hasLocation W20199981991 @default.
• W2019998199 hasLocation W20199981992 @default.
• W2019998199 hasOpenAccess W2019998199 @default.
• W2019998199 hasPrimaryLocation W20199981991 @default.
• W2019998199 hasRelatedWork W1950566777 @default.
• W2019998199 hasRelatedWork W2019998199 @default.
• W2019998199 hasRelatedWork W2050491411 @default.
• W2019998199 hasRelatedWork W2058632936 @default.
• W2019998199 hasRelatedWork W2087695253 @default.
• W2019998199 hasRelatedWork W2117367996 @default.
• W2019998199 hasRelatedWork W2152837630 @default.

• next