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- W2019998456 abstract "Recent studies have provided insights into the modular structure of genetic regulatory networks and emphasized the interest of quantitative functional descriptions. Here, to provide a priori knowledge of the structure of functional modules, we describe an evolutionary procedure in silico that creates small gene networks performing basic tasks. We used it to create networks functioning as bistable switches or oscillators. The obtained circuits provide a variety of functional designs, demonstrate the crucial role of posttranscriptional interactions, and highlight design principles also found in known biological networks. The procedure should prove helpful as a way to understand and create small functional modules with diverse functions as well as to analyze large networks." @default.
- W2019998456 created "2016-06-24" @default.
- W2019998456 creator A5056287697 @default.
- W2019998456 creator A5077212476 @default.
- W2019998456 date "2004-01-02" @default.
- W2019998456 modified "2023-09-30" @default.
- W2019998456 title "Design of genetic networks with specified functions by evolution <i>in silico</i>" @default.
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- W2019998456 doi "https://doi.org/10.1073/pnas.0304532101" @default.
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