Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019998457> ?p ?o ?g. }
- W2019998457 endingPage "e1097" @default.
- W2019998457 startingPage "e1097" @default.
- W2019998457 abstract "Amyloidogenic 'gain-of-function' mutations in apolipoprotein A-I (ApoA-I) gene (APOA1) result in systemic amyloidosis characterized by aggregate deposition and eventually cell death. However, how amyloidogenic variants of ApoA-I induce cell death is unknown. Here we report that one of the mechanisms by which amyloidogenic ApoA-I induces cell death is through attenuating anti-stress activity of angiogenin (ANG), a homeostatic protein having both pro-growth and pro-survival functions. Under growth conditions, ANG is located in nucleolus where it promotes ribosomal RNA (rRNA) transcription thereby stimulating cell growth. In adverse conditions, ANG is relocated to cytoplasm to promote damage repairs and cell survival. We find that in cells overexpressing the L75P-APOA1 mutant ANG expression is decreased and normal cellular localization of ANG is altered in response to stress and growth signals. In particular, ANG does not relocate to cytoplasm under stress conditions but is rather retained in the nucleolus where it continues promoting rRNA transcription, thus imposing a ribotoxic effect while simultaneously compromising its pro-survival activity. Consistently, we also find that addition of exogenous ANG protects cells from L75P-ApoA-I-induced apoptosis." @default.
- W2019998457 created "2016-06-24" @default.
- W2019998457 creator A5012483129 @default.
- W2019998457 creator A5015755938 @default.
- W2019998457 creator A5019806846 @default.
- W2019998457 creator A5026182869 @default.
- W2019998457 creator A5083924752 @default.
- W2019998457 creator A5090198287 @default.
- W2019998457 date "2014-03-06" @default.
- W2019998457 modified "2023-10-10" @default.
- W2019998457 title "Amyloidogenic variant of apolipoprotein A-I elicits cellular stress by attenuating the protective activity of angiogenin" @default.
- W2019998457 cites W1539469412 @default.
- W2019998457 cites W1810319741 @default.
- W2019998457 cites W1947043095 @default.
- W2019998457 cites W1966816746 @default.
- W2019998457 cites W1970511495 @default.
- W2019998457 cites W1972254064 @default.
- W2019998457 cites W1972479546 @default.
- W2019998457 cites W1985480771 @default.
- W2019998457 cites W1990096485 @default.
- W2019998457 cites W2000556101 @default.
- W2019998457 cites W2009040420 @default.
- W2019998457 cites W2009912607 @default.
- W2019998457 cites W2014409886 @default.
- W2019998457 cites W2021944349 @default.
- W2019998457 cites W2022025789 @default.
- W2019998457 cites W2023556666 @default.
- W2019998457 cites W2023989786 @default.
- W2019998457 cites W2027742580 @default.
- W2019998457 cites W2030048891 @default.
- W2019998457 cites W2044154503 @default.
- W2019998457 cites W2047573465 @default.
- W2019998457 cites W2047913804 @default.
- W2019998457 cites W2056673221 @default.
- W2019998457 cites W2056831129 @default.
- W2019998457 cites W2058661925 @default.
- W2019998457 cites W2060619028 @default.
- W2019998457 cites W2063183749 @default.
- W2019998457 cites W2069493167 @default.
- W2019998457 cites W2073097074 @default.
- W2019998457 cites W2073230597 @default.
- W2019998457 cites W2075284175 @default.
- W2019998457 cites W2079463373 @default.
- W2019998457 cites W2086044130 @default.
- W2019998457 cites W2087595883 @default.
- W2019998457 cites W2094322449 @default.
- W2019998457 cites W2096096265 @default.
- W2019998457 cites W2109140791 @default.
- W2019998457 cites W2117979108 @default.
- W2019998457 cites W2119633239 @default.
- W2019998457 cites W2134135259 @default.
- W2019998457 cites W2141462626 @default.
- W2019998457 cites W2149403492 @default.
- W2019998457 cites W2151570770 @default.
- W2019998457 cites W2161239412 @default.
- W2019998457 cites W2163870791 @default.
- W2019998457 cites W2167678675 @default.
- W2019998457 doi "https://doi.org/10.1038/cddis.2014.45" @default.
- W2019998457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3973227" @default.
- W2019998457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24603325" @default.
- W2019998457 hasPublicationYear "2014" @default.
- W2019998457 type Work @default.
- W2019998457 sameAs 2019998457 @default.
- W2019998457 citedByCount "8" @default.
- W2019998457 countsByYear W20199984572014 @default.
- W2019998457 countsByYear W20199984572015 @default.
- W2019998457 countsByYear W20199984572016 @default.
- W2019998457 countsByYear W20199984572017 @default.
- W2019998457 countsByYear W20199984572020 @default.
- W2019998457 countsByYear W20199984572021 @default.
- W2019998457 countsByYear W20199984572022 @default.
- W2019998457 crossrefType "journal-article" @default.
- W2019998457 hasAuthorship W2019998457A5012483129 @default.
- W2019998457 hasAuthorship W2019998457A5015755938 @default.
- W2019998457 hasAuthorship W2019998457A5019806846 @default.
- W2019998457 hasAuthorship W2019998457A5026182869 @default.
- W2019998457 hasAuthorship W2019998457A5083924752 @default.
- W2019998457 hasAuthorship W2019998457A5090198287 @default.
- W2019998457 hasBestOaLocation W20199984571 @default.
- W2019998457 hasConcept C138885662 @default.
- W2019998457 hasConcept C179926584 @default.
- W2019998457 hasConcept C183873130 @default.
- W2019998457 hasConcept C185592680 @default.
- W2019998457 hasConcept C190062978 @default.
- W2019998457 hasConcept C190283241 @default.
- W2019998457 hasConcept C2776719180 @default.
- W2019998457 hasConcept C2780394083 @default.
- W2019998457 hasConcept C31573885 @default.
- W2019998457 hasConcept C41895202 @default.
- W2019998457 hasConcept C502942594 @default.
- W2019998457 hasConcept C55493867 @default.
- W2019998457 hasConcept C62112901 @default.
- W2019998457 hasConcept C86803240 @default.
- W2019998457 hasConcept C95444343 @default.
- W2019998457 hasConceptScore W2019998457C138885662 @default.
- W2019998457 hasConceptScore W2019998457C179926584 @default.
- W2019998457 hasConceptScore W2019998457C183873130 @default.
- W2019998457 hasConceptScore W2019998457C185592680 @default.