Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019998653> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2019998653 abstract "Vaccines targeting beta-amyloid represent promising strategies for the treatment of AD. Immunization approaches provided encouraging results in mouse models and a subsequent human clinical trial (AN1792). Whereas preclinical studies in murine models did not show evidence of T cell-related side effects, the AN1792 trial had to be interrupted due to the development of meningoencephalitis attributed to pro-inflammatory T cell responses in 6% of the patients. Several reports also suggest that beta-amyloid -specific CD4 + T cells may be implicated in the pathophysiology of AD and could have a strong therapeutic potential as well, further supporting the need for better understanding the role and regulation of T cell responses to beta-amyloid. We previously showed that regulatory T cells (Tregs) critically control the magnitude of beta-amyloid-specific CD4 + T cell responses in both physiological and pathological settings in response to vaccination. However, the actual role of Tregs in the pathophysiology of AD remains unknown. We analyzed the impact of Tregs on disease progression in a murine model of AD. APPPS1 mice were depleted of Treg cells by injecting anti-CD25 antibodies, and the impact of Treg depletion on the neuropathology and cognitive deficits was evaluated. Depletion of Treg cells accelerated the onset of cognitive deficits in APPPS1 mice. Alteration in spatial memory was detected starting from 7 months in Treg-depleted animals, while PBS-treated APPPS1 mice were not yet cognitively impaired as compared to wild-type animals. Early cognitive impairment in Treg-depleted mice was correlated with alterations in the neuroinflammatory response that is associated with disease progression. Treg cells play a beneficial role in the pathophysiology of AD and delay disease progression in a murine model of the disease. These data open new perspectives in the development of Treg-based innovative immunotherapy approaches for the treatment of AD." @default.
- W2019998653 created "2016-06-24" @default.
- W2019998653 creator A5003366291 @default.
- W2019998653 creator A5029144785 @default.
- W2019998653 creator A5032531390 @default.
- W2019998653 creator A5049525948 @default.
- W2019998653 creator A5053144142 @default.
- W2019998653 creator A5055643519 @default.
- W2019998653 creator A5057954933 @default.
- W2019998653 creator A5089526892 @default.
- W2019998653 date "2013-07-01" @default.
- W2019998653 modified "2023-10-17" @default.
- W2019998653 title "O4–10–03: Regulatory T cells delay disease progression in a murine model of Alzheimer's disease" @default.
- W2019998653 doi "https://doi.org/10.1016/j.jalz.2013.04.391" @default.
- W2019998653 hasPublicationYear "2013" @default.
- W2019998653 type Work @default.
- W2019998653 sameAs 2019998653 @default.
- W2019998653 citedByCount "0" @default.
- W2019998653 crossrefType "journal-article" @default.
- W2019998653 hasAuthorship W2019998653A5003366291 @default.
- W2019998653 hasAuthorship W2019998653A5029144785 @default.
- W2019998653 hasAuthorship W2019998653A5032531390 @default.
- W2019998653 hasAuthorship W2019998653A5049525948 @default.
- W2019998653 hasAuthorship W2019998653A5053144142 @default.
- W2019998653 hasAuthorship W2019998653A5055643519 @default.
- W2019998653 hasAuthorship W2019998653A5057954933 @default.
- W2019998653 hasAuthorship W2019998653A5089526892 @default.
- W2019998653 hasConcept C10162356 @default.
- W2019998653 hasConcept C142724271 @default.
- W2019998653 hasConcept C169760540 @default.
- W2019998653 hasConcept C203014093 @default.
- W2019998653 hasConcept C2776090121 @default.
- W2019998653 hasConcept C2776156579 @default.
- W2019998653 hasConcept C2776914184 @default.
- W2019998653 hasConcept C2777633098 @default.
- W2019998653 hasConcept C2778296632 @default.
- W2019998653 hasConcept C2779134260 @default.
- W2019998653 hasConcept C2780130745 @default.
- W2019998653 hasConcept C71924100 @default.
- W2019998653 hasConcept C79484868 @default.
- W2019998653 hasConcept C86803240 @default.
- W2019998653 hasConcept C87753298 @default.
- W2019998653 hasConcept C8891405 @default.
- W2019998653 hasConceptScore W2019998653C10162356 @default.
- W2019998653 hasConceptScore W2019998653C142724271 @default.
- W2019998653 hasConceptScore W2019998653C169760540 @default.
- W2019998653 hasConceptScore W2019998653C203014093 @default.
- W2019998653 hasConceptScore W2019998653C2776090121 @default.
- W2019998653 hasConceptScore W2019998653C2776156579 @default.
- W2019998653 hasConceptScore W2019998653C2776914184 @default.
- W2019998653 hasConceptScore W2019998653C2777633098 @default.
- W2019998653 hasConceptScore W2019998653C2778296632 @default.
- W2019998653 hasConceptScore W2019998653C2779134260 @default.
- W2019998653 hasConceptScore W2019998653C2780130745 @default.
- W2019998653 hasConceptScore W2019998653C71924100 @default.
- W2019998653 hasConceptScore W2019998653C79484868 @default.
- W2019998653 hasConceptScore W2019998653C86803240 @default.
- W2019998653 hasConceptScore W2019998653C87753298 @default.
- W2019998653 hasConceptScore W2019998653C8891405 @default.
- W2019998653 hasIssue "4S_Part_17" @default.
- W2019998653 hasLocation W20199986531 @default.
- W2019998653 hasOpenAccess W2019998653 @default.
- W2019998653 hasPrimaryLocation W20199986531 @default.
- W2019998653 hasRelatedWork W2034441290 @default.
- W2019998653 hasRelatedWork W2059748759 @default.
- W2019998653 hasRelatedWork W2106304681 @default.
- W2019998653 hasRelatedWork W2352803447 @default.
- W2019998653 hasRelatedWork W2809913775 @default.
- W2019998653 hasRelatedWork W3191673686 @default.
- W2019998653 hasRelatedWork W3194937827 @default.
- W2019998653 hasRelatedWork W4200501434 @default.
- W2019998653 hasRelatedWork W4280507671 @default.
- W2019998653 hasRelatedWork W44588492 @default.
- W2019998653 hasVolume "9" @default.
- W2019998653 isParatext "false" @default.
- W2019998653 isRetracted "false" @default.
- W2019998653 magId "2019998653" @default.
- W2019998653 workType "article" @default.