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• W2019999250 abstract "Abstract Interleukin‐1β (IL‐1β) is associated with seizure‐induced neuronal cell death in the adult brain. The contribution of IL‐1β to neuronal injury induced by status epilepticus (SE) in the immature brain remains unclear. In the present study, we investigated the effects of IL‐1β administration on hippocampal neuronal cell death associated with SE in the immature brain, and the role of the type I receptor of IL‐1β (IL‐1RI). SE was induced with lithium–pilocarpine in 14‐days‐old (P14) rat pups. Six hours after SE onset, pups were i.c.v. injected in the right ventricle with IL‐1β (0, 0.3, 3, 30, or 300 ng), 30 ng of IL‐1RI antagonist (IL‐1Ra) alone, or 30 ng of IL‐1Ra plus 3 ng of IL‐1β. As control groups, pups without seizures were injected with 3 ng of IL‐1β or vehicle. Twenty‐four hours after SE onset, neuronal cell death in the CA1 field of dorsal hippocampus was assessed by hematoxylin–eosin, Fluoro‐Jade B and in vivo propidium iodide (PI) staining; expression of active caspase‐3 (aCas‐3) was also determined, using immunohistochemistry. The concentration–response curve of IL‐1β showed a bell‐shape. Only pups injected with 3 ng of IL‐1β after SE showed a significant increase in the number of cells with eosinophilic cytoplasm and pyknotic nuclei, as well as F‐JB positive cells with respect to the vehicle group. This effect was prevented when IL‐1β was injected with IL‐1Ra. Injection of 3 ng of IL‐1β increased the number of PI‐positive cells in CA1 area after SE. Injection of 3 ng of IL‐1β did not produce hippocampal cell death in rats without seizures. Active caspase‐3 expression was not observed after treatments in hippocampus. The activation of the IL‐1β/IL‐1RI system increases necrotic neuronal cell death caused by SE in rat pups." @default.
• W2019999250 created "2016-06-24" @default.
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• W2019999250 date "2014-10-20" @default.
• W2019999250 modified "2023-10-18" @default.
• W2019999250 title "IL‐1β increases necrotic neuronal cell death in the developing rat hippocampus after status epilepticus by activating type I IL‐1 receptor (IL‐1RI)" @default.
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• W2019999250 doi "https://doi.org/10.1016/j.ijdevneu.2014.09.006" @default.
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