FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020000360> ?p ?o ?g. }

• W2020000360 endingPage "88" @default.
• W2020000360 startingPage "80" @default.
• W2020000360 abstract "The work focused on screening the impact of various excipients and/or procedure in a new method that consists in a CO2-induced precipitation of a drug on a slurry. Naproxen (NPX) is a drug whose bioavailability could be improved by formulation with hydrophilic excipients. The investigated excipients were of various type, size and porosity, i.e. mannitol, silicas (SiO2 and SIO2 aminopropyl) and an anion exchange resin Duolite. The precipitation process used compressed CO2 as antisolvent for NPX and acetone as solvent to dissolve NPX and to suspend the excipient particles. Naproxen precipitated as crystals with a size distribution influenced by the NPX:excipient ratio for mannitol-based formulations. For other excipient co-precipitates, the overall size distributions were in the same range and below 330 μm except for the 5 μm silica. Due to the hydrophilic nature of the excipients, most formulations yielded an increased drug dissolution rate. Compared to physical mixtures, the benefit of the CO2 treatment was demonstrated in case of the excipient mannitol." @default.
• W2020000360 created "2016-06-24" @default.
• W2020000360 creator A5011863984 @default.
• W2020000360 creator A5028105579 @default.
• W2020000360 creator A5040892203 @default.
• W2020000360 creator A5041357184 @default.
• W2020000360 creator A5078579210 @default.
• W2020000360 date "2014-03-01" @default.
• W2020000360 modified "2023-10-03" @default.
• W2020000360 title "Preparation of naproxen–excipient formulations by CO2 precipitation on a slurry" @default.
• W2020000360 cites W1973149628 @default.
• W2020000360 cites W1974532222 @default.
• W2020000360 cites W1978246377 @default.
• W2020000360 cites W1989197775 @default.
• W2020000360 cites W1989583290 @default.
• W2020000360 cites W1990061030 @default.
• W2020000360 cites W1993641119 @default.
• W2020000360 cites W1993891338 @default.
• W2020000360 cites W1994745733 @default.
• W2020000360 cites W1996102102 @default.
• W2020000360 cites W2000287592 @default.
• W2020000360 cites W2008503709 @default.
• W2020000360 cites W2009956521 @default.
• W2020000360 cites W2012911843 @default.
• W2020000360 cites W2014321400 @default.
• W2020000360 cites W2026423221 @default.
• W2020000360 cites W2030262272 @default.
• W2020000360 cites W2044594845 @default.
• W2020000360 cites W2050699324 @default.
• W2020000360 cites W2056699349 @default.
• W2020000360 cites W2057816637 @default.
• W2020000360 cites W2074817119 @default.
• W2020000360 cites W2080373676 @default.
• W2020000360 cites W2082598931 @default.
• W2020000360 cites W2089129742 @default.
• W2020000360 cites W2095407037 @default.
• W2020000360 cites W2099939273 @default.
• W2020000360 cites W2102803971 @default.
• W2020000360 cites W2159992280 @default.
• W2020000360 cites W2164069109 @default.
• W2020000360 doi "https://doi.org/10.1016/j.powtec.2013.09.012" @default.
• W2020000360 hasPublicationYear "2014" @default.
• W2020000360 type Work @default.
• W2020000360 sameAs 2020000360 @default.
• W2020000360 citedByCount "5" @default.
• W2020000360 countsByYear W20200003602013 @default.
• W2020000360 countsByYear W20200003602014 @default.
• W2020000360 countsByYear W20200003602015 @default.
• W2020000360 countsByYear W20200003602019 @default.
• W2020000360 crossrefType "journal-article" @default.
• W2020000360 hasAuthorship W2020000360A5011863984 @default.
• W2020000360 hasAuthorship W2020000360A5028105579 @default.
• W2020000360 hasAuthorship W2020000360A5040892203 @default.
• W2020000360 hasAuthorship W2020000360A5041357184 @default.
• W2020000360 hasAuthorship W2020000360A5078579210 @default.
• W2020000360 hasConcept C107054158 @default.
• W2020000360 hasConcept C121332964 @default.
• W2020000360 hasConcept C127413603 @default.
• W2020000360 hasConcept C142724271 @default.
• W2020000360 hasConcept C153294291 @default.
• W2020000360 hasConcept C159985019 @default.
• W2020000360 hasConcept C185592680 @default.
• W2020000360 hasConcept C192562407 @default.
• W2020000360 hasConcept C204787440 @default.
• W2020000360 hasConcept C2777239854 @default.
• W2020000360 hasConcept C2778115740 @default.
• W2020000360 hasConcept C2984430287 @default.
• W2020000360 hasConcept C42360764 @default.
• W2020000360 hasConcept C43617362 @default.
• W2020000360 hasConcept C71924100 @default.
• W2020000360 hasConcept C94293008 @default.
• W2020000360 hasConceptScore W2020000360C107054158 @default.
• W2020000360 hasConceptScore W2020000360C121332964 @default.
• W2020000360 hasConceptScore W2020000360C127413603 @default.
• W2020000360 hasConceptScore W2020000360C142724271 @default.
• W2020000360 hasConceptScore W2020000360C153294291 @default.
• W2020000360 hasConceptScore W2020000360C159985019 @default.
• W2020000360 hasConceptScore W2020000360C185592680 @default.
• W2020000360 hasConceptScore W2020000360C192562407 @default.
• W2020000360 hasConceptScore W2020000360C204787440 @default.
• W2020000360 hasConceptScore W2020000360C2777239854 @default.
• W2020000360 hasConceptScore W2020000360C2778115740 @default.
• W2020000360 hasConceptScore W2020000360C2984430287 @default.
• W2020000360 hasConceptScore W2020000360C42360764 @default.
• W2020000360 hasConceptScore W2020000360C43617362 @default.
• W2020000360 hasConceptScore W2020000360C71924100 @default.
• W2020000360 hasConceptScore W2020000360C94293008 @default.
• W2020000360 hasLocation W20200003601 @default.
• W2020000360 hasOpenAccess W2020000360 @default.
• W2020000360 hasPrimaryLocation W20200003601 @default.
• W2020000360 hasRelatedWork W1970901780 @default.
• W2020000360 hasRelatedWork W2020000360 @default.
• W2020000360 hasRelatedWork W2025328782 @default.
• W2020000360 hasRelatedWork W2060483407 @default.
• W2020000360 hasRelatedWork W2079561018 @default.
• W2020000360 hasRelatedWork W2086350132 @default.
• W2020000360 hasRelatedWork W2105806934 @default.
• W2020000360 hasRelatedWork W2748952813 @default.

• next