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• W2020001510 abstract "A serious drawback of peptide nucleic acids (PNAs) from an application perspective that has not been adequately dealt with is nondiscrimination of identical DNA and RNA sequences. An analysis of the available X-ray and NMR solution structures of PNA complexes with DNA and RNA suggested that it might be possible to rationally impart DNA/RNA duplex binding selectivity by tuning the dihedral angle β of the flexible ethylenediamine part of the PNA backbone (II) via suitable chemical modifications. Cyclohexanyl PNAs (chPNAs) with β ≈ 65° were designed on the basis of this rationale. The chPNAs introduced remarkable differences in duplex stabilities among their DNA and RNA complexes, with melting temperatures (ΔTm(RNA−DNA) = +16−50 °C) depending on the number of modifications and the stereochemistry. This is a highly significant, exceptional binding selectivity of a mix sequence of PNA to RNA over the same DNA sequence as that seen to date. In contrast, cyclopentanyl PNAs (cpPNAs) with β ≈ 25° hybridize to DNA/RNA strongly without discrimination because of the ring puckering of the cyclopentane ring. The high affinity of chPNAs to bind to RNA without losing base specificity will have immediate implications in designing improved PNAs for therapeutic and diagnostic applications." @default.
• W2020001510 created "2016-06-24" @default.
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• W2020001510 date "2005-12-13" @default.
• W2020001510 modified "2023-10-15" @default.
• W2020001510 title "Cyclohexanyl Peptide Nucleic Acids (chPNAs) for Preferential RNA Binding: Effective Tuning of Dihedral Angle β in PNAs for DNA/RNA Discrimination" @default.
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• W2020001510 doi "https://doi.org/10.1021/jo051227l" @default.
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