FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020001674> ?p ?o ?g. }

• W2020001674 endingPage "4852" @default.
• W2020001674 startingPage "4845" @default.
• W2020001674 abstract "Abstract Context: The Bcl-2 family of proteins regulates apoptosis in various models and may represent a promising therapeutic target in human malignancies. Objective/Methods: We evaluated the sensitivity of thyroid carcinoma cell lines (two papillary, one follicular, two anaplastic, three medullary) in vitro to BH3I-1 and BH3I-2′, two cell-permeable inhibitors of the Bcl-2 homology (BH)-3 domain-mediated interaction between proapoptotic and antiapoptotic Bcl-2 family members. The thyroid carcinoma cell line FRO was stably transfected with cDNA for Bcl-2 or constitutively active Akt and evaluated for sensitivity to BH3-domain inhibition. Results: BH3-domain inhibition disrupted the mitochondrial membrane potential in thyroid carcinoma cells, induced caspase-dependent apoptosis, and potently sensitized them to sublethal concentrations of doxorubicin and the proteasome inhibitor bortezomib (Velcade). Overexpression of constitutively active Akt suppressed BH3I-1-induced cell death. Bcl-2-overexpressing FRO cells were more resistant to conventional chemotherapeutic agents (such as doxorubicin) but significantly more sensitive to BH3I-1 than control cells and were found to overexpress caspase-9, caspase-8, Bmf, Bok, and Bik transcripts and express less A1, BRaf, and FLIP transcripts. Conclusions: Bcl-2 expression protects thyroid carcinomas against chemotherapy-induced apoptosis. Nevertheless, overexpression of Bcl-2 may result in “oncogene addiction” of the cancer cell, which can be exploited by using BH3-domain inhibitors alone or in combination with other agents, including conventional chemotherapeutics (such as doxorubicin) or novel targeted therapies (such as the proteasome inhibitor bortezomib), for the treatment of aggressive thyroid cancer, including the medullary and anaplastic types." @default.
• W2020001674 created "2016-06-24" @default.
• W2020001674 creator A5010021766 @default.
• W2020001674 creator A5012712111 @default.
• W2020001674 creator A5030002291 @default.
• W2020001674 creator A5035386093 @default.
• W2020001674 creator A5044162398 @default.
• W2020001674 creator A5051365519 @default.
• W2020001674 creator A5069337891 @default.
• W2020001674 creator A5074712719 @default.
• W2020001674 creator A5091354090 @default.
• W2020001674 date "2007-12-01" @default.
• W2020001674 modified "2023-09-25" @default.
• W2020001674 title "Bcl-2 Overexpression in Thyroid Carcinoma Cells Increases Sensitivity to Bcl-2 Homology 3 Domain Inhibition" @default.
• W2020001674 cites W1499746632 @default.
• W2020001674 cites W1607777232 @default.
• W2020001674 cites W1965734230 @default.
• W2020001674 cites W1978343328 @default.
• W2020001674 cites W1978559408 @default.
• W2020001674 cites W1980837484 @default.
• W2020001674 cites W1984547206 @default.
• W2020001674 cites W1986771356 @default.
• W2020001674 cites W2008715871 @default.
• W2020001674 cites W2011785467 @default.
• W2020001674 cites W2024996523 @default.
• W2020001674 cites W2026334721 @default.
• W2020001674 cites W2040508081 @default.
• W2020001674 cites W2043432881 @default.
• W2020001674 cites W2043696829 @default.
• W2020001674 cites W2043999641 @default.
• W2020001674 cites W2044922611 @default.
• W2020001674 cites W2063337004 @default.
• W2020001674 cites W2068100481 @default.
• W2020001674 cites W2072252062 @default.
• W2020001674 cites W2078766933 @default.
• W2020001674 cites W2089298737 @default.
• W2020001674 cites W2097007474 @default.
• W2020001674 cites W2097290512 @default.
• W2020001674 cites W2103894337 @default.
• W2020001674 cites W2131112007 @default.
• W2020001674 cites W2139236349 @default.
• W2020001674 cites W2139977915 @default.
• W2020001674 cites W2155292823 @default.
• W2020001674 cites W2156547454 @default.
• W2020001674 cites W2157805786 @default.
• W2020001674 cites W2162123587 @default.
• W2020001674 cites W2163104010 @default.
• W2020001674 cites W2166601968 @default.
• W2020001674 cites W2169995312 @default.
• W2020001674 doi "https://doi.org/10.1210/jc.2007-0942" @default.
• W2020001674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17848408" @default.
• W2020001674 hasPublicationYear "2007" @default.
• W2020001674 type Work @default.
• W2020001674 sameAs 2020001674 @default.
• W2020001674 citedByCount "25" @default.
• W2020001674 countsByYear W20200016742012 @default.
• W2020001674 countsByYear W20200016742013 @default.
• W2020001674 countsByYear W20200016742016 @default.
• W2020001674 countsByYear W20200016742017 @default.
• W2020001674 countsByYear W20200016742018 @default.
• W2020001674 countsByYear W20200016742019 @default.
• W2020001674 countsByYear W20200016742020 @default.
• W2020001674 countsByYear W20200016742021 @default.
• W2020001674 countsByYear W20200016742023 @default.
• W2020001674 crossrefType "journal-article" @default.
• W2020001674 hasAuthorship W2020001674A5010021766 @default.
• W2020001674 hasAuthorship W2020001674A5012712111 @default.
• W2020001674 hasAuthorship W2020001674A5030002291 @default.
• W2020001674 hasAuthorship W2020001674A5035386093 @default.
• W2020001674 hasAuthorship W2020001674A5044162398 @default.
• W2020001674 hasAuthorship W2020001674A5051365519 @default.
• W2020001674 hasAuthorship W2020001674A5069337891 @default.
• W2020001674 hasAuthorship W2020001674A5074712719 @default.
• W2020001674 hasAuthorship W2020001674A5091354090 @default.
• W2020001674 hasBestOaLocation W20200016741 @default.
• W2020001674 hasConcept C121608353 @default.
• W2020001674 hasConcept C126322002 @default.
• W2020001674 hasConcept C134018914 @default.
• W2020001674 hasConcept C190283241 @default.
• W2020001674 hasConcept C2776364478 @default.
• W2020001674 hasConcept C2776694085 @default.
• W2020001674 hasConcept C2777478702 @default.
• W2020001674 hasConcept C2778367456 @default.
• W2020001674 hasConcept C2779761222 @default.
• W2020001674 hasConcept C2781018059 @default.
• W2020001674 hasConcept C2781303535 @default.
• W2020001674 hasConcept C29537977 @default.
• W2020001674 hasConcept C2993294228 @default.
• W2020001674 hasConcept C502942594 @default.
• W2020001674 hasConcept C526584372 @default.
• W2020001674 hasConcept C54009773 @default.
• W2020001674 hasConcept C54355233 @default.
• W2020001674 hasConcept C55493867 @default.
• W2020001674 hasConcept C71924100 @default.
• W2020001674 hasConcept C81885089 @default.
• W2020001674 hasConcept C86803240 @default.
• W2020001674 hasConcept C96232424 @default.
• W2020001674 hasConceptScore W2020001674C121608353 @default.

• next