FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020002352> ?p ?o ?g. }

• W2020002352 endingPage "560" @default.
• W2020002352 startingPage "550" @default.
• W2020002352 abstract "With an annual incidence of over 660,000 deaths, hepatocellular carcinoma (HCC) is the third leading cause of cancer death globally. This disease is often diagnosed at an advanced stage, when potentially curative therapies are not feasible. HCC is highly resistant to conventional systemic therapies and prognosis for advanced HCC patients remains poor. Given the clear need, clinical development of novel therapeutic agents in HCC has begun in earnest. Our recent knowledge of the molecular mechanisms responsible of tumor initiation and progression has identified several potential molecular targets in HCC. These targets are the receptor tyrosine kinase-activated pathways, which include the Raf/MEK/ERK, PI-3K/Akt/mTOR, and Jak/Stat. Sorafenib is the multikinase inhibitor that has shown modest survival benefits in advanced HCC in two randomized controlled trials, supporting the use of molecularly targeted therapies in treatment of HCC. A number of strategies including monoclonal antibodies and tyrosine kinase inhibitors such as erlotinib, sunitinib, vandetanib, cediranib, brivanib, foretinib, and dovitinib have been developed and tested in various phases of clinical trials. The successful development of these novel targeted agents in the future will be dependent on the selection of patient populations that are most likely to derive clinical benefit, optimization of the dose used and schedules, and investigation of combined therapies. This review describes evolving molecular targeted agents, their common adverse side effects, and its potential use in management of HCC." @default.
• W2020002352 created "2016-06-24" @default.
• W2020002352 creator A5066564166 @default.
• W2020002352 date "2010-09-01" @default.
• W2020002352 modified "2023-10-01" @default.
• W2020002352 title "Molecularly targeted therapy in hepatocellular carcinoma" @default.
• W2020002352 cites W1964935829 @default.
• W2020002352 cites W1971190195 @default.
• W2020002352 cites W1971837077 @default.
• W2020002352 cites W1974024530 @default.
• W2020002352 cites W1975293227 @default.
• W2020002352 cites W1976048849 @default.
• W2020002352 cites W1976689062 @default.
• W2020002352 cites W1981388207 @default.
• W2020002352 cites W1984322505 @default.
• W2020002352 cites W1987053006 @default.
• W2020002352 cites W1987982168 @default.
• W2020002352 cites W1989911225 @default.
• W2020002352 cites W1990276332 @default.
• W2020002352 cites W1991148380 @default.
• W2020002352 cites W1993919875 @default.
• W2020002352 cites W1994668492 @default.
• W2020002352 cites W1997554957 @default.
• W2020002352 cites W1999713229 @default.
• W2020002352 cites W2003735188 @default.
• W2020002352 cites W2005317229 @default.
• W2020002352 cites W2006113962 @default.
• W2020002352 cites W2006166594 @default.
• W2020002352 cites W2006206600 @default.
• W2020002352 cites W2007685062 @default.
• W2020002352 cites W2009899654 @default.
• W2020002352 cites W2010397777 @default.
• W2020002352 cites W2013123523 @default.
• W2020002352 cites W2017821197 @default.
• W2020002352 cites W2020509813 @default.
• W2020002352 cites W2021625611 @default.
• W2020002352 cites W2023447208 @default.
• W2020002352 cites W2023815439 @default.
• W2020002352 cites W2024674016 @default.
• W2020002352 cites W2025787635 @default.
• W2020002352 cites W2027402570 @default.
• W2020002352 cites W2027773493 @default.
• W2020002352 cites W2029336551 @default.
• W2020002352 cites W2031614751 @default.
• W2020002352 cites W2034548257 @default.
• W2020002352 cites W2038909417 @default.
• W2020002352 cites W2039548371 @default.
• W2020002352 cites W2042571415 @default.
• W2020002352 cites W2044404885 @default.
• W2020002352 cites W2045147990 @default.
• W2020002352 cites W2046052619 @default.
• W2020002352 cites W2048097275 @default.
• W2020002352 cites W2050637252 @default.
• W2020002352 cites W2052766257 @default.
• W2020002352 cites W2054529141 @default.
• W2020002352 cites W2058388078 @default.
• W2020002352 cites W2065960304 @default.
• W2020002352 cites W2067224679 @default.
• W2020002352 cites W2067691895 @default.
• W2020002352 cites W2069167650 @default.
• W2020002352 cites W2069434008 @default.
• W2020002352 cites W2070396671 @default.
• W2020002352 cites W2073025925 @default.
• W2020002352 cites W2073891760 @default.
• W2020002352 cites W2081167500 @default.
• W2020002352 cites W2085547877 @default.
• W2020002352 cites W2088629624 @default.
• W2020002352 cites W2091874984 @default.
• W2020002352 cites W2093116780 @default.
• W2020002352 cites W2093953283 @default.
• W2020002352 cites W2098046058 @default.
• W2020002352 cites W2098096093 @default.
• W2020002352 cites W2099087398 @default.
• W2020002352 cites W2101031676 @default.
• W2020002352 cites W2102055984 @default.
• W2020002352 cites W2105677187 @default.
• W2020002352 cites W2106321700 @default.
• W2020002352 cites W2108353976 @default.
• W2020002352 cites W2113222623 @default.
• W2020002352 cites W2113788015 @default.
• W2020002352 cites W2115497785 @default.
• W2020002352 cites W2117713501 @default.
• W2020002352 cites W2117807601 @default.
• W2020002352 cites W2118471405 @default.
• W2020002352 cites W2119022434 @default.
• W2020002352 cites W2119823629 @default.
• W2020002352 cites W2121707384 @default.
• W2020002352 cites W2125305744 @default.
• W2020002352 cites W2126655764 @default.
• W2020002352 cites W2128271300 @default.
• W2020002352 cites W2128412799 @default.
• W2020002352 cites W2130921495 @default.
• W2020002352 cites W2131990270 @default.
• W2020002352 cites W2132206048 @default.
• W2020002352 cites W2132395321 @default.
• W2020002352 cites W2134138119 @default.
• W2020002352 cites W2136745780 @default.
• W2020002352 cites W2136977965 @default.

• next