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• W2020004369 startingPage "245" @default.
• W2020004369 abstract "Severe chronic pain afflicts a large number of people worldwide but satisfactory relief from such pain is difficult to achieve with drugs that are currently available, and so there is a great need for the development of new, efficacious and safe analgesics. Voltage-gated calcium-permeable ion channels are multi-subunit complexes that regulate neuronal excitability, action-potential firing patterns and neurotransmission in nociceptive pathways. Although multiple subtypes of voltage-gated calcium channels exist, pharmacological and ion-channel gene knockdown approaches in animals have revealed N-type and T-type calcium channels to be particularly attractive molecular targets for the discovery and development of new analgesic drugs. The recent approval of Prialt (Elan Pharmaceuticals) provides the ultimate target validation for N-type calcium channels, namely proof that they are key regulators of nociceptive signaling in humans." @default.
• W2020004369 created "2016-06-24" @default.
• W2020004369 creator A5005552368 @default.
• W2020004369 date "2006-03-01" @default.
• W2020004369 modified "2023-09-25" @default.
• W2020004369 title "Targeting N-type and T-type calcium channels for the treatment of pain" @default.
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