Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020004435> ?p ?o ?g. }
- W2020004435 endingPage "212" @default.
- W2020004435 startingPage "199" @default.
- W2020004435 abstract "Vascular Endothelial Growth Factor (VEGF) is a pivotal endothelial cell mitogen that mediates both normal and pathological angiogenesis. Although expressed at very low levels in cells not undergoing vascularization, VEGF mRNA is transiently upregulated and stabilized by a variety of extracellular stimuli, and is persistently upregulated and stabilized in many human tumor cell lines (White et al., 1995). Here we demonstrate that oncogenic activation of tyrosine protein kinases and Ras proteins induce a 6-to 16-fold increase in the abundance of VEGF mRNA and a 3-to 5-fold increase in the stability of VEGF mRNA, suggesting that persistent activation of signaling pathways induced by these oncoproteins accounts for overexpression of VEGF in a significant fraction of human tumors. In addition to these oncoproteins, ultraviolet (U V) radiation upregulated and stabilized VEGF mRNA 15-and 5-fold, respectively. While the tyrosine kinase inhibitor, genistein, blocked VEGF upregulation by activated tyrosine protein kinases, and the Ras inhibitor, N-Acetyl-S-trans-farnesyl-l-cysteine (AFC), eliminated VEGF expression in cells transformed by v-Ras, neither agent blocked upregulation by hypoxia or UV radiation. These data argue that multiple divergent pathways upregulate and stabilize VEGF mRNA." @default.
- W2020004435 created "2016-06-24" @default.
- W2020004435 creator A5029960212 @default.
- W2020004435 creator A5030407634 @default.
- W2020004435 creator A5061413614 @default.
- W2020004435 creator A5086559436 @default.
- W2020004435 date "1997-01-01" @default.
- W2020004435 modified "2023-10-06" @default.
- W2020004435 title "VEGF mRNA is Stabilized by Ras and Tyrosine Kinase Oncogenes, as well as by UV Radiation—Evidence for Divergent Stabilization Pathways" @default.
- W2020004435 cites W110914879 @default.
- W2020004435 cites W1503667331 @default.
- W2020004435 cites W1536635467 @default.
- W2020004435 cites W1537712767 @default.
- W2020004435 cites W1821310871 @default.
- W2020004435 cites W1905486804 @default.
- W2020004435 cites W1944310027 @default.
- W2020004435 cites W1973553476 @default.
- W2020004435 cites W1974653642 @default.
- W2020004435 cites W1976999762 @default.
- W2020004435 cites W1981450136 @default.
- W2020004435 cites W1983051282 @default.
- W2020004435 cites W1988403143 @default.
- W2020004435 cites W1988416092 @default.
- W2020004435 cites W1991958278 @default.
- W2020004435 cites W1997936885 @default.
- W2020004435 cites W1999223106 @default.
- W2020004435 cites W2000290369 @default.
- W2020004435 cites W2001748566 @default.
- W2020004435 cites W2003962192 @default.
- W2020004435 cites W2015344488 @default.
- W2020004435 cites W2016904444 @default.
- W2020004435 cites W2019273955 @default.
- W2020004435 cites W2026834760 @default.
- W2020004435 cites W2028401492 @default.
- W2020004435 cites W2035762178 @default.
- W2020004435 cites W2038449972 @default.
- W2020004435 cites W2038750685 @default.
- W2020004435 cites W2043863730 @default.
- W2020004435 cites W2049827480 @default.
- W2020004435 cites W2055987653 @default.
- W2020004435 cites W2069132844 @default.
- W2020004435 cites W2072839085 @default.
- W2020004435 cites W2078811540 @default.
- W2020004435 cites W2080532845 @default.
- W2020004435 cites W2084506573 @default.
- W2020004435 cites W2087523741 @default.
- W2020004435 cites W2100272171 @default.
- W2020004435 cites W2101301592 @default.
- W2020004435 cites W2114098415 @default.
- W2020004435 cites W2120190211 @default.
- W2020004435 cites W2128462886 @default.
- W2020004435 cites W2133881086 @default.
- W2020004435 cites W2135938642 @default.
- W2020004435 cites W2158743409 @default.
- W2020004435 cites W2160246980 @default.
- W2020004435 cites W4232777855 @default.
- W2020004435 cites W4294216491 @default.
- W2020004435 doi "https://doi.org/10.3109/08977199709021520" @default.
- W2020004435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9255609" @default.
- W2020004435 hasPublicationYear "1997" @default.
- W2020004435 type Work @default.
- W2020004435 sameAs 2020004435 @default.
- W2020004435 citedByCount "57" @default.
- W2020004435 countsByYear W20200044352013 @default.
- W2020004435 countsByYear W20200044352014 @default.
- W2020004435 countsByYear W20200044352015 @default.
- W2020004435 countsByYear W20200044352021 @default.
- W2020004435 countsByYear W20200044352023 @default.
- W2020004435 crossrefType "journal-article" @default.
- W2020004435 hasAuthorship W2020004435A5029960212 @default.
- W2020004435 hasAuthorship W2020004435A5030407634 @default.
- W2020004435 hasAuthorship W2020004435A5061413614 @default.
- W2020004435 hasAuthorship W2020004435A5086559436 @default.
- W2020004435 hasConcept C101544691 @default.
- W2020004435 hasConcept C104317684 @default.
- W2020004435 hasConcept C105580179 @default.
- W2020004435 hasConcept C127561419 @default.
- W2020004435 hasConcept C146285616 @default.
- W2020004435 hasConcept C153911025 @default.
- W2020004435 hasConcept C167734588 @default.
- W2020004435 hasConcept C184235292 @default.
- W2020004435 hasConcept C185592680 @default.
- W2020004435 hasConcept C2776165026 @default.
- W2020004435 hasConcept C2777025900 @default.
- W2020004435 hasConcept C2780394083 @default.
- W2020004435 hasConcept C42362537 @default.
- W2020004435 hasConcept C502942594 @default.
- W2020004435 hasConcept C55493867 @default.
- W2020004435 hasConcept C57074206 @default.
- W2020004435 hasConcept C62478195 @default.
- W2020004435 hasConcept C86803240 @default.
- W2020004435 hasConcept C95444343 @default.
- W2020004435 hasConceptScore W2020004435C101544691 @default.
- W2020004435 hasConceptScore W2020004435C104317684 @default.
- W2020004435 hasConceptScore W2020004435C105580179 @default.
- W2020004435 hasConceptScore W2020004435C127561419 @default.
- W2020004435 hasConceptScore W2020004435C146285616 @default.
- W2020004435 hasConceptScore W2020004435C153911025 @default.