Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020004868> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2020004868 endingPage "753" @default.
- W2020004868 startingPage "747" @default.
- W2020004868 abstract "Ribavirin at a concentration of 30 μg/ml added immediately after infection completely inhibited influenza A/Port Chalmers/1/73 (H 3 N 2 ) virus hemagglutinin production in infected MDCK cells. Under these conditions, host cell protein synthesis was inhibited by only 10 to 20%. Polyacrylamide gel electrophoresis of [ 35 S]methionine-labeled material from virus-infected cultures confirmed that ribavirin inhibited viral but not host cell protein synthesis. In parallel experiments, actinomycin D also preferentially inhibited viral protein synthesis. The possibility that ribavirin inhibited viral protein synthesis as a result of general inhibition of ribonucleic acid synthesis was therefore examined. In uninfected cells, ribavirin at 30 μg/ml inhibited the incorporation of [ 14 C]inosine or [ 3 H]uridine into ribonucleic acid but stimulated the incorporation of [ 3 H]guanosine. The effects noted are consistent with an inhibition of the host cell enzyme inosine 5′-monophosphate dehydrogenase. This suggestion is supported by the finding that addition of guanosine, but not inosine, to the culture medium substantially reversed the antiviral effect of ribavirin. There was no separation between the concentration of ribavirin causing inhibition of influenza A viral protein synthesis or inhibition of MDCK cell ribonucleic acid synthesis, suggesting that ribavirin is not specifically antiviral in this system but inhibits viral protein synthesis as a result of the general inhibition of ribonucleic acid synthesis." @default.
- W2020004868 created "2016-06-24" @default.
- W2020004868 creator A5032289244 @default.
- W2020004868 date "1979-06-01" @default.
- W2020004868 modified "2023-09-24" @default.
- W2020004868 title "Mechanism and Specificity of Action of Ribavirin" @default.
- W2020004868 doi "https://doi.org/10.1128/aac.15.6.747" @default.
- W2020004868 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/352752" @default.
- W2020004868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/475358" @default.
- W2020004868 hasPublicationYear "1979" @default.
- W2020004868 type Work @default.
- W2020004868 sameAs 2020004868 @default.
- W2020004868 citedByCount "41" @default.
- W2020004868 countsByYear W20200048682015 @default.
- W2020004868 countsByYear W20200048682019 @default.
- W2020004868 countsByYear W20200048682020 @default.
- W2020004868 countsByYear W20200048682023 @default.
- W2020004868 crossrefType "journal-article" @default.
- W2020004868 hasAuthorship W2020004868A5032289244 @default.
- W2020004868 hasBestOaLocation W20200048681 @default.
- W2020004868 hasConcept C104317684 @default.
- W2020004868 hasConcept C141071460 @default.
- W2020004868 hasConcept C153911025 @default.
- W2020004868 hasConcept C159047783 @default.
- W2020004868 hasConcept C181199279 @default.
- W2020004868 hasConcept C2522874641 @default.
- W2020004868 hasConcept C2776408679 @default.
- W2020004868 hasConcept C2777610669 @default.
- W2020004868 hasConcept C2777995097 @default.
- W2020004868 hasConcept C2778033501 @default.
- W2020004868 hasConcept C2780040827 @default.
- W2020004868 hasConcept C2781259782 @default.
- W2020004868 hasConcept C2909748322 @default.
- W2020004868 hasConcept C2911091166 @default.
- W2020004868 hasConcept C3675279 @default.
- W2020004868 hasConcept C38596361 @default.
- W2020004868 hasConcept C512185932 @default.
- W2020004868 hasConcept C55493867 @default.
- W2020004868 hasConcept C67705224 @default.
- W2020004868 hasConcept C71924100 @default.
- W2020004868 hasConcept C86803240 @default.
- W2020004868 hasConceptScore W2020004868C104317684 @default.
- W2020004868 hasConceptScore W2020004868C141071460 @default.
- W2020004868 hasConceptScore W2020004868C153911025 @default.
- W2020004868 hasConceptScore W2020004868C159047783 @default.
- W2020004868 hasConceptScore W2020004868C181199279 @default.
- W2020004868 hasConceptScore W2020004868C2522874641 @default.
- W2020004868 hasConceptScore W2020004868C2776408679 @default.
- W2020004868 hasConceptScore W2020004868C2777610669 @default.
- W2020004868 hasConceptScore W2020004868C2777995097 @default.
- W2020004868 hasConceptScore W2020004868C2778033501 @default.
- W2020004868 hasConceptScore W2020004868C2780040827 @default.
- W2020004868 hasConceptScore W2020004868C2781259782 @default.
- W2020004868 hasConceptScore W2020004868C2909748322 @default.
- W2020004868 hasConceptScore W2020004868C2911091166 @default.
- W2020004868 hasConceptScore W2020004868C3675279 @default.
- W2020004868 hasConceptScore W2020004868C38596361 @default.
- W2020004868 hasConceptScore W2020004868C512185932 @default.
- W2020004868 hasConceptScore W2020004868C55493867 @default.
- W2020004868 hasConceptScore W2020004868C67705224 @default.
- W2020004868 hasConceptScore W2020004868C71924100 @default.
- W2020004868 hasConceptScore W2020004868C86803240 @default.
- W2020004868 hasIssue "6" @default.
- W2020004868 hasLocation W20200048681 @default.
- W2020004868 hasLocation W20200048682 @default.
- W2020004868 hasLocation W20200048683 @default.
- W2020004868 hasOpenAccess W2020004868 @default.
- W2020004868 hasPrimaryLocation W20200048681 @default.
- W2020004868 hasRelatedWork W1600597578 @default.
- W2020004868 hasRelatedWork W1968049351 @default.
- W2020004868 hasRelatedWork W1968855143 @default.
- W2020004868 hasRelatedWork W1969206572 @default.
- W2020004868 hasRelatedWork W1980840486 @default.
- W2020004868 hasRelatedWork W1982301628 @default.
- W2020004868 hasRelatedWork W1984386728 @default.
- W2020004868 hasRelatedWork W1989179485 @default.
- W2020004868 hasRelatedWork W2012051375 @default.
- W2020004868 hasRelatedWork W2017727103 @default.
- W2020004868 hasRelatedWork W2026106960 @default.
- W2020004868 hasRelatedWork W2046137419 @default.
- W2020004868 hasRelatedWork W2048726074 @default.
- W2020004868 hasRelatedWork W2058320288 @default.
- W2020004868 hasRelatedWork W2064172664 @default.
- W2020004868 hasRelatedWork W2079066605 @default.
- W2020004868 hasRelatedWork W2087261548 @default.
- W2020004868 hasRelatedWork W2092900809 @default.
- W2020004868 hasRelatedWork W2143554772 @default.
- W2020004868 hasRelatedWork W3212268252 @default.
- W2020004868 hasVolume "15" @default.
- W2020004868 isParatext "false" @default.
- W2020004868 isRetracted "false" @default.
- W2020004868 magId "2020004868" @default.
- W2020004868 workType "article" @default.