FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020007154> ?p ?o ?g. }

• W2020007154 endingPage "1940" @default.
• W2020007154 startingPage "1930" @default.
• W2020007154 abstract "The NS5A protein plays a critical role in the replication of HCV and has been the focus of numerous research efforts over the past few years. NS5A inhibitors have shown impressive in vitro potency profiles in HCV replicon assays, making them attractive components for inclusion in all oral combination regimens. Early work in the NS5A arena led to the discovery of our first clinical candidate, MK-4882 [2-((S)-pyrrolidin-2-yl)-5-(2-(4-(5-((S)-pyrrolidin-2-yl)-1H-imidazol-2-yl)phenyl)benzofuran-5-yl)-1H-imidazole]. While preclinical proof-of-concept studies in HCV-infected chimpanzees harboring chronic genotype 1 infections resulted in significant decreases in viral load after both single- and multiple-dose treatments, viral breakthrough proved to be a concern, thus necessitating the development of compounds with increased potency against a number of genotypes and NS5A resistance mutations. Modification of the MK-4882 core scaffold by introduction of a cyclic constraint afforded a series of tetracyclic inhibitors, which showed improved virologic profiles. Herein we describe the research efforts that led to the discovery of MK-8742, a tetracyclic indole-based NS5A inhibitor, which is currently in phase 2b clinical trials as part of an all-oral, interferon-free regimen for the treatment of HCV infection." @default.
• W2020007154 created "2016-06-24" @default.
• W2020007154 creator A5001164647 @default.
• W2020007154 creator A5004460784 @default.
• W2020007154 creator A5006011924 @default.
• W2020007154 creator A5007479812 @default.
• W2020007154 creator A5008172062 @default.
• W2020007154 creator A5011805749 @default.
• W2020007154 creator A5014074447 @default.
• W2020007154 creator A5018636031 @default.
• W2020007154 creator A5027177687 @default.
• W2020007154 creator A5036666565 @default.
• W2020007154 creator A5050737001 @default.
• W2020007154 creator A5055735136 @default.
• W2020007154 creator A5056237284 @default.
• W2020007154 creator A5058186904 @default.
• W2020007154 creator A5068229772 @default.
• W2020007154 creator A5069580821 @default.
• W2020007154 creator A5079818410 @default.
• W2020007154 creator A5083758750 @default.
• W2020007154 creator A5090176699 @default.
• W2020007154 date "2013-10-14" @default.
• W2020007154 modified "2023-10-15" @default.
• W2020007154 title "Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity" @default.
• W2020007154 cites W1881009043 @default.
• W2020007154 cites W1990099082 @default.
• W2020007154 cites W1995591620 @default.
• W2020007154 cites W1998717812 @default.
• W2020007154 cites W2024763248 @default.
• W2020007154 cites W2027253904 @default.
• W2020007154 cites W2054768505 @default.
• W2020007154 cites W2056622178 @default.
• W2020007154 cites W2068253682 @default.
• W2020007154 cites W2070587341 @default.
• W2020007154 cites W2075095707 @default.
• W2020007154 cites W2078239010 @default.
• W2020007154 cites W2085689632 @default.
• W2020007154 cites W2093695226 @default.
• W2020007154 cites W2106378149 @default.
• W2020007154 cites W2140231399 @default.
• W2020007154 cites W2147516929 @default.
• W2020007154 cites W2162240080 @default.
• W2020007154 cites W2163818375 @default.
• W2020007154 cites W2166962970 @default.
• W2020007154 doi "https://doi.org/10.1002/cmdc.201300343" @default.
• W2020007154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24127258" @default.
• W2020007154 hasPublicationYear "2013" @default.
• W2020007154 type Work @default.
• W2020007154 sameAs 2020007154 @default.
• W2020007154 citedByCount "184" @default.
• W2020007154 countsByYear W20200071542014 @default.
• W2020007154 countsByYear W20200071542015 @default.
• W2020007154 countsByYear W20200071542016 @default.
• W2020007154 countsByYear W20200071542017 @default.
• W2020007154 countsByYear W20200071542018 @default.
• W2020007154 countsByYear W20200071542019 @default.
• W2020007154 countsByYear W20200071542020 @default.
• W2020007154 countsByYear W20200071542021 @default.
• W2020007154 countsByYear W20200071542022 @default.
• W2020007154 countsByYear W20200071542023 @default.
• W2020007154 crossrefType "journal-article" @default.
• W2020007154 hasAuthorship W2020007154A5001164647 @default.
• W2020007154 hasAuthorship W2020007154A5004460784 @default.
• W2020007154 hasAuthorship W2020007154A5006011924 @default.
• W2020007154 hasAuthorship W2020007154A5007479812 @default.
• W2020007154 hasAuthorship W2020007154A5008172062 @default.
• W2020007154 hasAuthorship W2020007154A5011805749 @default.
• W2020007154 hasAuthorship W2020007154A5014074447 @default.
• W2020007154 hasAuthorship W2020007154A5018636031 @default.
• W2020007154 hasAuthorship W2020007154A5027177687 @default.
• W2020007154 hasAuthorship W2020007154A5036666565 @default.
• W2020007154 hasAuthorship W2020007154A5050737001 @default.
• W2020007154 hasAuthorship W2020007154A5055735136 @default.
• W2020007154 hasAuthorship W2020007154A5056237284 @default.
• W2020007154 hasAuthorship W2020007154A5058186904 @default.
• W2020007154 hasAuthorship W2020007154A5068229772 @default.
• W2020007154 hasAuthorship W2020007154A5069580821 @default.
• W2020007154 hasAuthorship W2020007154A5079818410 @default.
• W2020007154 hasAuthorship W2020007154A5083758750 @default.
• W2020007154 hasAuthorship W2020007154A5090176699 @default.
• W2020007154 hasConcept C159047783 @default.
• W2020007154 hasConcept C202751555 @default.
• W2020007154 hasConcept C2522874641 @default.
• W2020007154 hasConcept C2776408679 @default.
• W2020007154 hasConcept C2777103181 @default.
• W2020007154 hasConcept C2781463415 @default.
• W2020007154 hasConcept C54355233 @default.
• W2020007154 hasConcept C57992300 @default.
• W2020007154 hasConcept C60644358 @default.
• W2020007154 hasConcept C71924100 @default.
• W2020007154 hasConcept C74187038 @default.
• W2020007154 hasConcept C86803240 @default.
• W2020007154 hasConcept C98274493 @default.
• W2020007154 hasConceptScore W2020007154C159047783 @default.
• W2020007154 hasConceptScore W2020007154C202751555 @default.
• W2020007154 hasConceptScore W2020007154C2522874641 @default.
• W2020007154 hasConceptScore W2020007154C2776408679 @default.
• W2020007154 hasConceptScore W2020007154C2777103181 @default.

• next