FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020011608> ?p ?o ?g. }

• W2020011608 endingPage "e95807" @default.
• W2020011608 startingPage "e95807" @default.
• W2020011608 abstract "High-density lipoprotein (HDL) is known to protect against atherosclerosis by promoting the reverse cholesterol transport. A new pathway for the regulation of HDL-cholesterol (HDL-c) removal involving F1-ATPase and P2Y13 receptor (P2Y13R) was described in vitro, and recently in mice. However, the physiological role of F1-ATPase/P2Y13R pathway in the modulation of vascular pathology i.e. in the development of atherosclerotic plaques is still unknown. We designed a specific novel agonist (CT1007900) of the P2Y13R that caused stimulation of bile acid secretion associated with an increased uptake of HDL-c in the liver after single dosing in mice. Repeated dose administration in mice, for 2 weeks, stimulated the apoA-I synthesis and formation of small HDL particles. Plasma samples from the agonist-treated mice had high efflux capacity for mobilization of cholesterol in vitro compared to placebo group. In apoE−/− mice this agonist induced a decrease of atherosclerotic plaques in aortas and carotids. The specificity of P2Y13R pathway in those mice was assessed using adenovirus encoding P2Y13R-shRNA. These results demonstrate that P2Y13R plays a pivotal role in the HDL metabolism and could also be a useful therapeutic agent to decrease atherosclerosis. In this study, the up-regulation of HDL-c metabolism via activation of the P2Y13R using agonists could promote reverse cholesterol transport and promote inhibition of atherosclerosis progression in mice." @default.
• W2020011608 created "2016-06-24" @default.
• W2020011608 creator A5002703746 @default.
• W2020011608 creator A5009932874 @default.
• W2020011608 creator A5019814257 @default.
• W2020011608 creator A5021776388 @default.
• W2020011608 creator A5025217199 @default.
• W2020011608 creator A5071128580 @default.
• W2020011608 creator A5073589190 @default.
• W2020011608 creator A5074546562 @default.
• W2020011608 creator A5074985146 @default.
• W2020011608 creator A5083830612 @default.
• W2020011608 date "2014-04-25" @default.
• W2020011608 modified "2023-09-25" @default.
• W2020011608 title "P2Y13 Receptor Regulates HDL Metabolism and Atherosclerosis In Vivo" @default.
• W2020011608 cites W1515206644 @default.
• W2020011608 cites W1858850028 @default.
• W2020011608 cites W1963610804 @default.
• W2020011608 cites W1965195541 @default.
• W2020011608 cites W1965982516 @default.
• W2020011608 cites W1967694134 @default.
• W2020011608 cites W1970640497 @default.
• W2020011608 cites W1989365906 @default.
• W2020011608 cites W2001777306 @default.
• W2020011608 cites W2007172615 @default.
• W2020011608 cites W2007270755 @default.
• W2020011608 cites W2008990589 @default.
• W2020011608 cites W2019005804 @default.
• W2020011608 cites W2022107800 @default.
• W2020011608 cites W2025165872 @default.
• W2020011608 cites W2040176292 @default.
• W2020011608 cites W2040713479 @default.
• W2020011608 cites W2042344342 @default.
• W2020011608 cites W2042840607 @default.
• W2020011608 cites W2054594146 @default.
• W2020011608 cites W2055823448 @default.
• W2020011608 cites W2056237991 @default.
• W2020011608 cites W2063276829 @default.
• W2020011608 cites W2066288680 @default.
• W2020011608 cites W2069360467 @default.
• W2020011608 cites W2070820319 @default.
• W2020011608 cites W2071388713 @default.
• W2020011608 cites W2075367810 @default.
• W2020011608 cites W2082918438 @default.
• W2020011608 cites W2089155225 @default.
• W2020011608 cites W2089450781 @default.
• W2020011608 cites W2093202258 @default.
• W2020011608 cites W2099172760 @default.
• W2020011608 cites W2106515170 @default.
• W2020011608 cites W2127651422 @default.
• W2020011608 cites W2136124501 @default.
• W2020011608 cites W2152354184 @default.
• W2020011608 cites W2185025112 @default.
• W2020011608 cites W2216795130 @default.
• W2020011608 doi "https://doi.org/10.1371/journal.pone.0095807" @default.
• W2020011608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4000210" @default.
• W2020011608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24769858" @default.
• W2020011608 hasPublicationYear "2014" @default.
• W2020011608 type Work @default.
• W2020011608 sameAs 2020011608 @default.
• W2020011608 citedByCount "16" @default.
• W2020011608 countsByYear W20200116082014 @default.
• W2020011608 countsByYear W20200116082015 @default.
• W2020011608 countsByYear W20200116082016 @default.
• W2020011608 countsByYear W20200116082017 @default.
• W2020011608 countsByYear W20200116082018 @default.
• W2020011608 countsByYear W20200116082019 @default.
• W2020011608 countsByYear W20200116082020 @default.
• W2020011608 crossrefType "journal-article" @default.
• W2020011608 hasAuthorship W2020011608A5002703746 @default.
• W2020011608 hasAuthorship W2020011608A5009932874 @default.
• W2020011608 hasAuthorship W2020011608A5019814257 @default.
• W2020011608 hasAuthorship W2020011608A5021776388 @default.
• W2020011608 hasAuthorship W2020011608A5025217199 @default.
• W2020011608 hasAuthorship W2020011608A5071128580 @default.
• W2020011608 hasAuthorship W2020011608A5073589190 @default.
• W2020011608 hasAuthorship W2020011608A5074546562 @default.
• W2020011608 hasAuthorship W2020011608A5074985146 @default.
• W2020011608 hasAuthorship W2020011608A5083830612 @default.
• W2020011608 hasBestOaLocation W20200116081 @default.
• W2020011608 hasConcept C110459506 @default.
• W2020011608 hasConcept C126322002 @default.
• W2020011608 hasConcept C134018914 @default.
• W2020011608 hasConcept C150903083 @default.
• W2020011608 hasConcept C170493617 @default.
• W2020011608 hasConcept C185592680 @default.
• W2020011608 hasConcept C207001950 @default.
• W2020011608 hasConcept C2778163477 @default.
• W2020011608 hasConcept C2778938600 @default.
• W2020011608 hasConcept C2779134260 @default.
• W2020011608 hasConcept C2780072125 @default.
• W2020011608 hasConcept C2780541478 @default.
• W2020011608 hasConcept C43554185 @default.
• W2020011608 hasConcept C4733338 @default.
• W2020011608 hasConcept C57089818 @default.
• W2020011608 hasConcept C71924100 @default.
• W2020011608 hasConcept C86803240 @default.
• W2020011608 hasConcept C98274493 @default.

• next