Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020011724> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2020011724 endingPage "25" @default.
- W2020011724 startingPage "21" @default.
- W2020011724 abstract "Lipoxygenase-pathway metabolites of arachidonic acid are produced in pancreatic islets. They are are implicated in insulin release, since nonselective inhibitors of lipoxygenases inhibit glucose-induced insulin release. We studied the interplay in insulin release between glucose and selected icosanoids formed in 5-, 12- and 15-lipoxygenase pathways. Effects on immunoreactive insulin release of 107 to 10-6 12-(R)-HETE, 12-(S)-HETE, hepoxilin A3, lipoxin B4, LTB4 or LTC4 were tested individually in 30-min incubations of freshly isolated young adult Wistar rat pancreatic islets, in the presence of 5.6 mM or 23 mM glucose. Basal insulin release (at 5.6 mM glucose) was stimulated by LTC4 and hepoxilin A3 (304% and 234% of controls at 5.6 mM glucose alone, respectively), inhibited by 12-(S)-HPETE (56%), and was not affected by 12-(R)-HETE, 12-(S)-HETE, lipoxin B4 or LTB4 (111%, 105%, 106% and 136%, respectively). Insulin release evoked by 23 mM glucose (190-2-320%) was inhibited (50–145%) by all icosanoids tested, except LTC4 (162%). We conclude that, among the lipoxygenase products tested, only leukotrienes and hepoxilin are candidates for a tonic-stimulatory influence on basal insulin release. Since glucose promotes icosanoid formation in islets, the observed inhibition of glucose-induced insulin release by lipoxygenase products suggests the existence of a negative-feedback system." @default.
- W2020011724 created "2016-06-24" @default.
- W2020011724 creator A5029597987 @default.
- W2020011724 creator A5084327086 @default.
- W2020011724 date "1990-05-01" @default.
- W2020011724 modified "2023-09-26" @default.
- W2020011724 title "Lipoxygenase-generated icosanoids inhibit glucose-induced insulin release from rat islets" @default.
- W2020011724 cites W1494372407 @default.
- W2020011724 cites W1541236869 @default.
- W2020011724 cites W1553551716 @default.
- W2020011724 cites W1604051618 @default.
- W2020011724 cites W1963949757 @default.
- W2020011724 cites W1971394450 @default.
- W2020011724 cites W1997010909 @default.
- W2020011724 cites W1997129347 @default.
- W2020011724 cites W2015121905 @default.
- W2020011724 cites W2029107666 @default.
- W2020011724 cites W2053387978 @default.
- W2020011724 cites W2055604016 @default.
- W2020011724 cites W2098858437 @default.
- W2020011724 cites W2151725211 @default.
- W2020011724 cites W2171355449 @default.
- W2020011724 cites W2321855881 @default.
- W2020011724 cites W4230623240 @default.
- W2020011724 cites W4238320891 @default.
- W2020011724 doi "https://doi.org/10.1016/0952-3278(90)90111-w" @default.
- W2020011724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2119040" @default.
- W2020011724 hasPublicationYear "1990" @default.
- W2020011724 type Work @default.
- W2020011724 sameAs 2020011724 @default.
- W2020011724 citedByCount "17" @default.
- W2020011724 crossrefType "journal-article" @default.
- W2020011724 hasAuthorship W2020011724A5029597987 @default.
- W2020011724 hasAuthorship W2020011724A5084327086 @default.
- W2020011724 hasBestOaLocation W20200117242 @default.
- W2020011724 hasConcept C126322002 @default.
- W2020011724 hasConcept C134018914 @default.
- W2020011724 hasConcept C165220095 @default.
- W2020011724 hasConcept C181199279 @default.
- W2020011724 hasConcept C185592680 @default.
- W2020011724 hasConcept C2776042228 @default.
- W2020011724 hasConcept C2776352991 @default.
- W2020011724 hasConcept C2776452501 @default.
- W2020011724 hasConcept C2778024521 @default.
- W2020011724 hasConcept C2778078955 @default.
- W2020011724 hasConcept C2779306644 @default.
- W2020011724 hasConcept C2779855799 @default.
- W2020011724 hasConcept C2780857362 @default.
- W2020011724 hasConcept C55493867 @default.
- W2020011724 hasConcept C71924100 @default.
- W2020011724 hasConcept C86803240 @default.
- W2020011724 hasConceptScore W2020011724C126322002 @default.
- W2020011724 hasConceptScore W2020011724C134018914 @default.
- W2020011724 hasConceptScore W2020011724C165220095 @default.
- W2020011724 hasConceptScore W2020011724C181199279 @default.
- W2020011724 hasConceptScore W2020011724C185592680 @default.
- W2020011724 hasConceptScore W2020011724C2776042228 @default.
- W2020011724 hasConceptScore W2020011724C2776352991 @default.
- W2020011724 hasConceptScore W2020011724C2776452501 @default.
- W2020011724 hasConceptScore W2020011724C2778024521 @default.
- W2020011724 hasConceptScore W2020011724C2778078955 @default.
- W2020011724 hasConceptScore W2020011724C2779306644 @default.
- W2020011724 hasConceptScore W2020011724C2779855799 @default.
- W2020011724 hasConceptScore W2020011724C2780857362 @default.
- W2020011724 hasConceptScore W2020011724C55493867 @default.
- W2020011724 hasConceptScore W2020011724C71924100 @default.
- W2020011724 hasConceptScore W2020011724C86803240 @default.
- W2020011724 hasIssue "1" @default.
- W2020011724 hasLocation W20200117241 @default.
- W2020011724 hasLocation W20200117242 @default.
- W2020011724 hasLocation W20200117243 @default.
- W2020011724 hasOpenAccess W2020011724 @default.
- W2020011724 hasPrimaryLocation W20200117241 @default.
- W2020011724 hasRelatedWork W1951162574 @default.
- W2020011724 hasRelatedWork W1970813167 @default.
- W2020011724 hasRelatedWork W1985965417 @default.
- W2020011724 hasRelatedWork W2009454127 @default.
- W2020011724 hasRelatedWork W2020011724 @default.
- W2020011724 hasRelatedWork W2064538767 @default.
- W2020011724 hasRelatedWork W2067890698 @default.
- W2020011724 hasRelatedWork W2071871778 @default.
- W2020011724 hasRelatedWork W2130116832 @default.
- W2020011724 hasRelatedWork W2328188075 @default.
- W2020011724 hasVolume "40" @default.
- W2020011724 isParatext "false" @default.
- W2020011724 isRetracted "false" @default.
- W2020011724 magId "2020011724" @default.
- W2020011724 workType "article" @default.