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- W2020016897 abstract "The activity of metabolic enzymes is controlled by three principle levels: the amount of enzyme, the catalytic activity, and the accessibility of substrates. Reversible lysine acetylation is emerging as a major regulatory mechanism in metabolism that is involved in all three levels of controlling metabolic enzymes and is altered frequently in human diseases. Acetylation rivals other common posttranslational modifications in cell regulation not only in the number of substrates it modifies, but also the variety of regulatory mechanisms it facilitates." @default.
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- W2020016897 date "2012-07-23" @default.
- W2020016897 modified "2023-10-11" @default.
- W2020016897 title "Mechanistic insights into the regulation of metabolic enzymes by acetylation" @default.
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- W2020016897 doi "https://doi.org/10.1083/jcb.201202056" @default.
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