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- W2020023268 abstract "Peyer’s patches (PP) have been previously shown to play a critical role in the initiation of acute lethal GVHD in a non-irradiated murine model (Murai et al., 2003). This report utilized IL-7 receptor antibody treatment of pregnant mice to inhibit the development of PPs in the fetus. We wanted to assess GVHD progression in mice congenitally deficient in PP presence and function. The absence of various members of the TNF and TNF-R families also affects secondary lymphoid structure and organization. The presence of PP has varied between different independently generated TNF knockout strains which may be related to the close linkages of tnf with lta and ltb genes. A new TNF deficient strain has been developed that lacks PPs, displays the defects characteristic of TNF ablation but not the LT associated defects characterized by lack of lymph nodes and defects in splenic microarchitecture. To examine the role of host-derived TNF family members in acute lethal GVHD, we also had to assess the role of secondary lymphoid structures. We utilized a full MHC mismatched mode of BALB/c (H2d) cells into myeloablated C57BL/6 (H2b) recipients. We lethally irradiated wild type (WT) mice, TNF-α deficient mice with Peyer’s patches (PP+) and TNF-α deficient mice without Peyer’s patches (PP-) followed by infusion of allogeneic bone marrow and spleen cells. We observed no difference in the survival of the three groups of mice (median day of death ranged from 26 to 27). In addition, no significant differences were observed in GVHD associated histopathological lesions in the small intestine. Hisopathological lesions observed in the colon were similar in both the PP+ and PP- TNF-α deficient recipients. Based on our observations, we conclude that (1) Peyer’s patches and (2) host TNF-α are not required for the development of acute lethal GVHD in mice that received extensive conditioning and allogeneic bone marrow transplantation." @default.
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- W2020023268 date "2004-02-01" @default.
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- W2020023268 title "The absence of Peyer’s patches or host TNF-A does not affect GVHD progression in an allogeneic BMT model using extensive conditioning regimens" @default.
- W2020023268 doi "https://doi.org/10.1016/j.bbmt.2003.12.264" @default.
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