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- W2020024609 abstract "REGRESS (Regression Growth Evaluation Statin Study) is a placebo controlled multicenter study to assess the effect of 2 year treatment with Pravastatin (PRAV) on progression and regression of angiographically documented coronary atherosclerosis (CA) in patients with a serum cholesterol between 4–8 mmol/l (155–310 mg/dl). Baseline and follow-up analyses of the coronary arteriograms was performed by quantitative computer analysis. The primary endpoints of the study, change in Mean Segment Diameter and Minimum Obstruction Diameter (MOD) averaged per patient, showed significant retardation of mean progression of CA in the PRAV-group as compared to the placebo (PLAC)-group. To determine whether this beneficial effect is attenuated by the presence of risk factors like smoking, hypertension, and obesity, we analyzed our data in this regard. at baseline the median MOD was 1.83 mm for smokers (n = 190) and 1.89 mm for non-smokers (n = 451, P = 0.02). Median changes of the MOD in the PLAC- and PRAY-group for smokers and non-smokers are shown in the table below.Empty CellPLACPRAVEmpty Cellsmokers-0.07 mm-0.04 mmp = 0.32non-smokers-0.10 mm-0.03 mmP = 0.0003p = 0.08p = 0.29 The pravastatin effect for non-smokers was 0.07 mm less progression and for smokers 0.03 mm less progression of CA. Adjusting for baseline MOD differences between smokers and non-smokers did-not alter this result. No major differences of the pravastatin effect could be demonstrated for subgroups of patients with or without hypertension or obesity. the beneficial effect of lipid lowering therapy on coronary atherosclerosis is diminished by 50% in patients who continue to smoke." @default.
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- W2020024609 date "1995-02-01" @default.
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- W2020024609 title "1028-122 The Beneficial Effects of Lipid Lowering Therapy by Pravastatin on Coronary Atherosclerosisis Diminished by 50% in Patients who Continue to Smoke" @default.
- W2020024609 doi "https://doi.org/10.1016/0735-1097(95)93170-h" @default.
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