Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020026579> ?p ?o ?g. }
- W2020026579 endingPage "357" @default.
- W2020026579 startingPage "346" @default.
- W2020026579 abstract "Glioblastoma cells exhibit highly invasive behavior whose mechanisms are not yet fully understood. The present study explores the relationship between the invasion capacity of 5 glioblastoma cell lines differing in p53 and PTEN status, expression of mTOR and several other marker proteins involved in cell invasion, actin cytoskeleton organization and cell morphology. We found that two glioblastoma lines mutated in both p53 and PTEN genes (U373-MG and SNB19) exhibited the highest invasion rates through the Matrigel or collagen matrix. In DK-MG (p53wt/PTENwt) and GaMG (p53mut/PTENwt) cells, F-actin mainly occurred in the numerous stress fibers spanning the cytoplasm, whereas U87-MG (p53wt/PTENmut), U373-MG and SNB19 (both p53mut/PTENmut) cells preferentially expressed F-actin in filopodia and lamellipodia. Scanning electron microscopy confirmed the abundant filopodia and lamellipodia in the PTEN mutated cell lines. Interestingly, the gene profiling analysis revealed two clusters of cell lines, corresponding to the most (U373-MG and SNB19, i.e. p53 and PTEN mutated cells) and less invasive phenotypes. The results of this study might shed new light on the mechanisms of glioblastoma invasion." @default.
- W2020026579 created "2016-06-24" @default.
- W2020026579 creator A5009855159 @default.
- W2020026579 creator A5020828238 @default.
- W2020026579 creator A5027494826 @default.
- W2020026579 creator A5031512659 @default.
- W2020026579 creator A5036442108 @default.
- W2020026579 creator A5037108285 @default.
- W2020026579 creator A5041152749 @default.
- W2020026579 creator A5046756579 @default.
- W2020026579 creator A5053053716 @default.
- W2020026579 creator A5054433502 @default.
- W2020026579 creator A5091806326 @default.
- W2020026579 date "2015-01-01" @default.
- W2020026579 modified "2023-09-25" @default.
- W2020026579 title "Actin cytoskeleton organization, cell surface modification and invasion rate of 5 glioblastoma cell lines differing in PTEN and p53 status" @default.
- W2020026579 cites W166240207 @default.
- W2020026579 cites W1910650341 @default.
- W2020026579 cites W1967114760 @default.
- W2020026579 cites W1971163936 @default.
- W2020026579 cites W1974584534 @default.
- W2020026579 cites W1975866732 @default.
- W2020026579 cites W1976520103 @default.
- W2020026579 cites W1978232668 @default.
- W2020026579 cites W1990208526 @default.
- W2020026579 cites W1995281982 @default.
- W2020026579 cites W1996983679 @default.
- W2020026579 cites W2005155951 @default.
- W2020026579 cites W2007903825 @default.
- W2020026579 cites W2014280822 @default.
- W2020026579 cites W2019318549 @default.
- W2020026579 cites W2019731805 @default.
- W2020026579 cites W2020993672 @default.
- W2020026579 cites W2023000631 @default.
- W2020026579 cites W2025183726 @default.
- W2020026579 cites W2035747691 @default.
- W2020026579 cites W2039233803 @default.
- W2020026579 cites W2040127848 @default.
- W2020026579 cites W2040196938 @default.
- W2020026579 cites W2047902687 @default.
- W2020026579 cites W2049132016 @default.
- W2020026579 cites W2055021586 @default.
- W2020026579 cites W2058142370 @default.
- W2020026579 cites W2065439764 @default.
- W2020026579 cites W2065455574 @default.
- W2020026579 cites W2065628422 @default.
- W2020026579 cites W2066591499 @default.
- W2020026579 cites W2075612906 @default.
- W2020026579 cites W2076457965 @default.
- W2020026579 cites W2077537799 @default.
- W2020026579 cites W2086641174 @default.
- W2020026579 cites W2096287682 @default.
- W2020026579 cites W2101428185 @default.
- W2020026579 cites W2106827909 @default.
- W2020026579 cites W2110452000 @default.
- W2020026579 cites W2112093320 @default.
- W2020026579 cites W2112752761 @default.
- W2020026579 cites W2113012900 @default.
- W2020026579 cites W2113282518 @default.
- W2020026579 cites W2114998237 @default.
- W2020026579 cites W2127063807 @default.
- W2020026579 cites W2129585918 @default.
- W2020026579 cites W2130711943 @default.
- W2020026579 cites W2142121807 @default.
- W2020026579 cites W2142540639 @default.
- W2020026579 cites W2144169031 @default.
- W2020026579 cites W2151492748 @default.
- W2020026579 cites W2153032620 @default.
- W2020026579 cites W2153672941 @default.
- W2020026579 cites W2157005154 @default.
- W2020026579 cites W2158681922 @default.
- W2020026579 cites W2159695799 @default.
- W2020026579 cites W2160937449 @default.
- W2020026579 cites W72550747 @default.
- W2020026579 doi "https://doi.org/10.1016/j.yexcr.2014.08.013" @default.
- W2020026579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25149900" @default.
- W2020026579 hasPublicationYear "2015" @default.
- W2020026579 type Work @default.
- W2020026579 sameAs 2020026579 @default.
- W2020026579 citedByCount "25" @default.
- W2020026579 countsByYear W20200265792016 @default.
- W2020026579 countsByYear W20200265792017 @default.
- W2020026579 countsByYear W20200265792018 @default.
- W2020026579 countsByYear W20200265792019 @default.
- W2020026579 countsByYear W20200265792020 @default.
- W2020026579 countsByYear W20200265792021 @default.
- W2020026579 countsByYear W20200265792022 @default.
- W2020026579 countsByYear W20200265792023 @default.
- W2020026579 crossrefType "journal-article" @default.
- W2020026579 hasAuthorship W2020026579A5009855159 @default.
- W2020026579 hasAuthorship W2020026579A5020828238 @default.
- W2020026579 hasAuthorship W2020026579A5027494826 @default.
- W2020026579 hasAuthorship W2020026579A5031512659 @default.
- W2020026579 hasAuthorship W2020026579A5036442108 @default.
- W2020026579 hasAuthorship W2020026579A5037108285 @default.
- W2020026579 hasAuthorship W2020026579A5041152749 @default.
- W2020026579 hasAuthorship W2020026579A5046756579 @default.
- W2020026579 hasAuthorship W2020026579A5053053716 @default.