Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020030635> ?p ?o ?g. }
- W2020030635 abstract "Liver has a unique vascular system receiving the majority of the blood supply from the gastrointestinal tract through the portal vein and faces continuous exposure to foreign pathogens and commensal bacterial products. These gut-derived antigens stimulate liver cells and result in a distinctive immune response via a family of pattern recognition receptors, the Toll-like receptors (TLRs). TLRs are expressed on Kupffer cells, dendritic cells, hepatic stellate cells, endothelial cells, and hepatocytes in the liver. The crosstalk between gut-derived antigens and TLRs on immune cells trigger a distinctive set of mechanisms to induce immunity, contributing to various acute and chronic liver diseases including liver cirrhosis and hepatocellular carcinoma. Accumulating evidence has shown that TLRs stimulation by foreign antigens induces the production of immunoactivating and immunoregulatory cytokines. Furthermore, the immunoregulatory arm of TLR stimulation can also control excessive tissue damage. With this knowledge at hand, it is important to clarify the dual role of disease-specific TLRs as activators and regulators, especially in the liver. We will review the current understanding of TLR signaling and subsequent immune activation and tolerance by the innate immune system in the liver." @default.
- W2020030635 created "2016-06-24" @default.
- W2020030635 creator A5045356124 @default.
- W2020030635 creator A5069724888 @default.
- W2020030635 date "2014-05-16" @default.
- W2020030635 modified "2023-10-01" @default.
- W2020030635 title "Role of Toll-Like Receptors in Immune Activation and Tolerance in the Liver" @default.
- W2020030635 cites W1489742081 @default.
- W2020030635 cites W1489842152 @default.
- W2020030635 cites W1498929362 @default.
- W2020030635 cites W1526716352 @default.
- W2020030635 cites W1528518768 @default.
- W2020030635 cites W1556694570 @default.
- W2020030635 cites W1560110579 @default.
- W2020030635 cites W1589525467 @default.
- W2020030635 cites W1891684625 @default.
- W2020030635 cites W1906591077 @default.
- W2020030635 cites W1950448919 @default.
- W2020030635 cites W1963588999 @default.
- W2020030635 cites W1970853163 @default.
- W2020030635 cites W1977577140 @default.
- W2020030635 cites W1978197109 @default.
- W2020030635 cites W1981087308 @default.
- W2020030635 cites W1984079725 @default.
- W2020030635 cites W1984704941 @default.
- W2020030635 cites W1986300628 @default.
- W2020030635 cites W1986337007 @default.
- W2020030635 cites W1987344938 @default.
- W2020030635 cites W1988787951 @default.
- W2020030635 cites W1988990189 @default.
- W2020030635 cites W1990906756 @default.
- W2020030635 cites W1995139611 @default.
- W2020030635 cites W1998156781 @default.
- W2020030635 cites W2001668931 @default.
- W2020030635 cites W2003747312 @default.
- W2020030635 cites W2003778885 @default.
- W2020030635 cites W2007448877 @default.
- W2020030635 cites W2010156274 @default.
- W2020030635 cites W2012277840 @default.
- W2020030635 cites W2014830942 @default.
- W2020030635 cites W2014980326 @default.
- W2020030635 cites W2015355701 @default.
- W2020030635 cites W2017730825 @default.
- W2020030635 cites W2018346422 @default.
- W2020030635 cites W2020219616 @default.
- W2020030635 cites W2020334653 @default.
- W2020030635 cites W2022763702 @default.
- W2020030635 cites W2025741354 @default.
- W2020030635 cites W2028682449 @default.
- W2020030635 cites W2032015767 @default.
- W2020030635 cites W2035320249 @default.
- W2020030635 cites W2035529748 @default.
- W2020030635 cites W2035966867 @default.
- W2020030635 cites W2037190876 @default.
- W2020030635 cites W2038992316 @default.
- W2020030635 cites W2039591388 @default.
- W2020030635 cites W2042083424 @default.
- W2020030635 cites W2042433863 @default.
- W2020030635 cites W2042694297 @default.
- W2020030635 cites W2048736082 @default.
- W2020030635 cites W2049115723 @default.
- W2020030635 cites W2049941037 @default.
- W2020030635 cites W2051373931 @default.
- W2020030635 cites W2055176387 @default.
- W2020030635 cites W2057121293 @default.
- W2020030635 cites W2062396270 @default.
- W2020030635 cites W2063917748 @default.
- W2020030635 cites W2069220094 @default.
- W2020030635 cites W2069668308 @default.
- W2020030635 cites W2075244147 @default.
- W2020030635 cites W2076794498 @default.
- W2020030635 cites W2077931779 @default.
- W2020030635 cites W2077940506 @default.
- W2020030635 cites W2083725282 @default.
- W2020030635 cites W2084918795 @default.
- W2020030635 cites W2088366586 @default.
- W2020030635 cites W2089573702 @default.
- W2020030635 cites W2094133741 @default.
- W2020030635 cites W2097139406 @default.
- W2020030635 cites W2097639161 @default.
- W2020030635 cites W2100820895 @default.
- W2020030635 cites W2101147174 @default.
- W2020030635 cites W2103843518 @default.
- W2020030635 cites W2103863906 @default.
- W2020030635 cites W2110389012 @default.
- W2020030635 cites W2110796494 @default.
- W2020030635 cites W2112295570 @default.
- W2020030635 cites W2114637517 @default.
- W2020030635 cites W2115583388 @default.
- W2020030635 cites W2115734680 @default.
- W2020030635 cites W2122921940 @default.
- W2020030635 cites W2128009173 @default.
- W2020030635 cites W2130662763 @default.
- W2020030635 cites W2130878425 @default.
- W2020030635 cites W2130992177 @default.
- W2020030635 cites W2132692852 @default.
- W2020030635 cites W2135131688 @default.
- W2020030635 cites W2138453840 @default.
- W2020030635 cites W2138608324 @default.
- W2020030635 cites W2138860727 @default.