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• W2020031180 endingPage "2020" @default.
• W2020031180 startingPage "2010" @default.
• W2020031180 abstract "The human keratin family comprises 54 members, 28 type I and 26 type II. Out of the 28 type I keratins, 17 are epithelial and 11 are hair keratins. Similarly, the 26 type II members comprise 20 epithelial and 6 hair keratins. As, however, 9 out of the 37 epithelial keratins are specifically expressed in the hair follicle, the total number of hair follicle-specific keratins (26) almost equals that of those expressed in the various forms of epithelia (28). Up to now, more than half of the latter have been found to be involved in inherited diseases, with mutated type I and type II members being roughly equally causal. In contrast, out of the 26 hair follicle-specific keratins only 5 have, at present, been associated with inherited hair disorders, while one keratin merely acts as a risk factor. In addition, all hair follicle-specific keratins involved in pathologies are type II keratins. Here we provide a detailed description of the respective hair diseases which are either due to mutations in hair keratins (monilethrix, ectodermal dysplasia of hair and nail type) or hair follicle-specific epithelial keratins (two mouse models, RCO3 and CaRin as well as pseudofolliculitis barbae)." @default.
• W2020031180 created "2016-06-24" @default.
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• W2020031180 creator A5053274927 @default.
• W2020031180 creator A5054900882 @default.
• W2020031180 date "2007-06-01" @default.
• W2020031180 modified "2023-10-01" @default.
• W2020031180 title "Hair follicle-specific keratins and their diseases" @default.
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• W2020031180 doi "https://doi.org/10.1016/j.yexcr.2007.02.032" @default.
• W2020031180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17428470" @default.
• W2020031180 hasPublicationYear "2007" @default.
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