Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020032046> ?p ?o ?g. }
- W2020032046 endingPage "e18452" @default.
- W2020032046 startingPage "e18452" @default.
- W2020032046 abstract "The superficial layer of the superior colliculus (sSC) receives visual inputs via two different pathways: from the retina and the primary visual cortex. However, the functional significance of each input for the operation of the sSC circuit remains to be identified. As a first step toward understanding the functional role of each of these inputs, we developed an optogenetic method to specifically suppress the synaptic transmission in the retino-tectal pathway. We introduced enhanced halorhodopsin (eNpHR), a yellow light-sensitive, membrane-targeting chloride pump, into mouse retinal ganglion cells (RGCs) by intravitreously injecting an adeno-associated virus serotype-2 vector carrying the CMV-eNpHR-EYFP construct. Several weeks after the injection, whole-cell recordings made from sSC neurons in slice preparations revealed that yellow laser illumination of the eNpHR-expressing retino-tectal axons, putatively synapsing onto the recorded cells, effectively inhibited EPSCs evoked by electrical stimulation of the optic nerve layer. We also showed that sSC spike activities elicited by visual stimulation were significantly reduced by laser illumination of the sSC in anesthetized mice. These results indicate that photo-activation of eNpHR expressed in RGC axons enables selective blockade of retino-tectal synaptic transmission. The method established here can most likely be applied to a variety of brain regions for studying the function of individual inputs to these regions." @default.
- W2020032046 created "2016-06-24" @default.
- W2020032046 creator A5002986053 @default.
- W2020032046 creator A5017834677 @default.
- W2020032046 creator A5033323490 @default.
- W2020032046 creator A5039783605 @default.
- W2020032046 creator A5045763682 @default.
- W2020032046 creator A5054384015 @default.
- W2020032046 creator A5073375045 @default.
- W2020032046 creator A5087668223 @default.
- W2020032046 date "2011-04-05" @default.
- W2020032046 modified "2023-10-16" @default.
- W2020032046 title "Selective Optical Control of Synaptic Transmission in the Subcortical Visual Pathway by Activation of Viral Vector-Expressed Halorhodopsin" @default.
- W2020032046 cites W1496101456 @default.
- W2020032046 cites W1508315241 @default.
- W2020032046 cites W1895837554 @default.
- W2020032046 cites W1966449010 @default.
- W2020032046 cites W1972869628 @default.
- W2020032046 cites W1977048094 @default.
- W2020032046 cites W1988990594 @default.
- W2020032046 cites W1999311112 @default.
- W2020032046 cites W2010416043 @default.
- W2020032046 cites W2010975466 @default.
- W2020032046 cites W2011154084 @default.
- W2020032046 cites W2017108196 @default.
- W2020032046 cites W2023732600 @default.
- W2020032046 cites W2038294038 @default.
- W2020032046 cites W2051526952 @default.
- W2020032046 cites W2052933309 @default.
- W2020032046 cites W2055352840 @default.
- W2020032046 cites W2062595406 @default.
- W2020032046 cites W2069041575 @default.
- W2020032046 cites W20793640 @default.
- W2020032046 cites W2083932518 @default.
- W2020032046 cites W2084811348 @default.
- W2020032046 cites W2100494357 @default.
- W2020032046 cites W2102248966 @default.
- W2020032046 cites W2112938540 @default.
- W2020032046 cites W2115656514 @default.
- W2020032046 cites W2115859705 @default.
- W2020032046 cites W2117220677 @default.
- W2020032046 cites W2119809315 @default.
- W2020032046 cites W2119842352 @default.
- W2020032046 cites W2127780691 @default.
- W2020032046 cites W2133022015 @default.
- W2020032046 cites W2159423248 @default.
- W2020032046 cites W2163438163 @default.
- W2020032046 cites W2164237857 @default.
- W2020032046 cites W2167095271 @default.
- W2020032046 cites W2409702941 @default.
- W2020032046 cites W2414182141 @default.
- W2020032046 cites W4294214781 @default.
- W2020032046 doi "https://doi.org/10.1371/journal.pone.0018452" @default.
- W2020032046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3071716" @default.
- W2020032046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21483674" @default.
- W2020032046 hasPublicationYear "2011" @default.
- W2020032046 type Work @default.
- W2020032046 sameAs 2020032046 @default.
- W2020032046 citedByCount "21" @default.
- W2020032046 countsByYear W20200320462012 @default.
- W2020032046 countsByYear W20200320462013 @default.
- W2020032046 countsByYear W20200320462016 @default.
- W2020032046 countsByYear W20200320462017 @default.
- W2020032046 countsByYear W20200320462018 @default.
- W2020032046 countsByYear W20200320462020 @default.
- W2020032046 countsByYear W20200320462021 @default.
- W2020032046 countsByYear W20200320462022 @default.
- W2020032046 crossrefType "journal-article" @default.
- W2020032046 hasAuthorship W2020032046A5002986053 @default.
- W2020032046 hasAuthorship W2020032046A5017834677 @default.
- W2020032046 hasAuthorship W2020032046A5033323490 @default.
- W2020032046 hasAuthorship W2020032046A5039783605 @default.
- W2020032046 hasAuthorship W2020032046A5045763682 @default.
- W2020032046 hasAuthorship W2020032046A5054384015 @default.
- W2020032046 hasAuthorship W2020032046A5073375045 @default.
- W2020032046 hasAuthorship W2020032046A5087668223 @default.
- W2020032046 hasBestOaLocation W20200320461 @default.
- W2020032046 hasConcept C119088629 @default.
- W2020032046 hasConcept C169760540 @default.
- W2020032046 hasConcept C170493617 @default.
- W2020032046 hasConcept C178253425 @default.
- W2020032046 hasConcept C189542057 @default.
- W2020032046 hasConcept C200170125 @default.
- W2020032046 hasConcept C24998067 @default.
- W2020032046 hasConcept C26760741 @default.
- W2020032046 hasConcept C2777093970 @default.
- W2020032046 hasConcept C2779345533 @default.
- W2020032046 hasConcept C2780827179 @default.
- W2020032046 hasConcept C2780837183 @default.
- W2020032046 hasConcept C2781416072 @default.
- W2020032046 hasConcept C2908832724 @default.
- W2020032046 hasConcept C36890616 @default.
- W2020032046 hasConcept C41625074 @default.
- W2020032046 hasConcept C50738837 @default.
- W2020032046 hasConcept C54355233 @default.
- W2020032046 hasConcept C55493867 @default.
- W2020032046 hasConcept C86803240 @default.
- W2020032046 hasConceptScore W2020032046C119088629 @default.