FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020033079> ?p ?o ?g. }

• W2020033079 endingPage "477" @default.
• W2020033079 startingPage "465" @default.
• W2020033079 abstract "Quinacrine complexes with native DNA (Calf thymus, Micrococcus lysodeikticus, Escherichia coli, Bacillus subtilis, and Colstridium perfringens) and synthetic polynucleotides (poly(dA) . poly(dT), poly[d(A-T)] . poly[d(A-T)], poly(dG) . poly(dC) and poly[d(G-C)] . poly[d(G-C)]) has been investigated in solution at 0.1 M NaCl, 0.05 M Tris HCl, 0.001 M EDTA, pH 7.5, at 20 degrees C. Fluorescence excitation spectra of complexes with dye concentration D = 5-30 microM and DNA phosphate concentration P = 400 microM have been examined from 300 to 500 nm, while collecting the emission above 520 nm. The amounts of free and bound quinacrine in the dye-DNA complexes have been determined by means of equilibrium dialysis experiments. Different affinities have been found for the various DNAs and their values have been examined with a model that assumes that the binding constants associated with alternating purine and pyrimidine sequences are larger than those relative to nonalternating ones. Among the alternating nearest neighbor base sequences, the Pyr(3'-5')Pur sequences, i.e., C-G, T-G, C-A and T-A seem to bind quinacrine stronger than the remaining sequences. In particular the three sites, where a G . C base pair is involved, are found to display higher affinities. Good agreement is found with recent calculations on the energetics of intercalation sites in DNA. The analysis of the equilibrium shows also that the strength of the excitation spectrum of bound dye depends strongly upon the ratio of bound quinacrine to DNA. This effect can be attributed to dye-dye energy transfer along DNA." @default.
• W2020033079 created "2016-06-24" @default.
• W2020033079 creator A5008733337 @default.
• W2020033079 creator A5048331693 @default.
• W2020033079 creator A5050264426 @default.
• W2020033079 creator A5082281389 @default.
• W2020033079 date "1981-12-01" @default.
• W2020033079 modified "2023-09-26" @default.
• W2020033079 title "Fluorescence-determined preferential binding of quinacrine to DNA" @default.
• W2020033079 cites W1553876477 @default.
• W2020033079 cites W1555554581 @default.
• W2020033079 cites W1858609664 @default.
• W2020033079 cites W1971777385 @default.
• W2020033079 cites W1985378108 @default.
• W2020033079 cites W1988404220 @default.
• W2020033079 cites W1995707633 @default.
• W2020033079 cites W1995881558 @default.
• W2020033079 cites W1998150847 @default.
• W2020033079 cites W1998195916 @default.
• W2020033079 cites W2016520550 @default.
• W2020033079 cites W2027836137 @default.
• W2020033079 cites W2029643136 @default.
• W2020033079 cites W2035678484 @default.
• W2020033079 cites W2036173104 @default.
• W2020033079 cites W2040830003 @default.
• W2020033079 cites W2047017284 @default.
• W2020033079 cites W2059090023 @default.
• W2020033079 cites W2062356925 @default.
• W2020033079 cites W2073010081 @default.
• W2020033079 cites W2073787422 @default.
• W2020033079 cites W2083053197 @default.
• W2020033079 cites W2089102945 @default.
• W2020033079 cites W2093674441 @default.
• W2020033079 cites W2170044879 @default.
• W2020033079 cites W2471340962 @default.
• W2020033079 cites W2919994410 @default.
• W2020033079 doi "https://doi.org/10.1016/s0006-3495(81)84746-7" @default.
• W2020033079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1327640" @default.
• W2020033079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7326321" @default.
• W2020033079 hasPublicationYear "1981" @default.
• W2020033079 type Work @default.
• W2020033079 sameAs 2020033079 @default.
• W2020033079 citedByCount "21" @default.
• W2020033079 countsByYear W20200330792012 @default.
• W2020033079 countsByYear W20200330792013 @default.
• W2020033079 countsByYear W20200330792017 @default.
• W2020033079 countsByYear W20200330792018 @default.
• W2020033079 countsByYear W20200330792019 @default.
• W2020033079 countsByYear W20200330792020 @default.
• W2020033079 countsByYear W20200330792021 @default.
• W2020033079 crossrefType "journal-article" @default.
• W2020033079 hasAuthorship W2020033079A5008733337 @default.
• W2020033079 hasAuthorship W2020033079A5048331693 @default.
• W2020033079 hasAuthorship W2020033079A5050264426 @default.
• W2020033079 hasAuthorship W2020033079A5082281389 @default.
• W2020033079 hasBestOaLocation W20200330791 @default.
• W2020033079 hasConcept C111921641 @default.
• W2020033079 hasConcept C121332964 @default.
• W2020033079 hasConcept C137824038 @default.
• W2020033079 hasConcept C179104552 @default.
• W2020033079 hasConcept C185581394 @default.
• W2020033079 hasConcept C185592680 @default.
• W2020033079 hasConcept C2777272437 @default.
• W2020033079 hasConcept C2780283098 @default.
• W2020033079 hasConcept C523546767 @default.
• W2020033079 hasConcept C54355233 @default.
• W2020033079 hasConcept C552990157 @default.
• W2020033079 hasConcept C55493867 @default.
• W2020033079 hasConcept C62520636 @default.
• W2020033079 hasConcept C71240020 @default.
• W2020033079 hasConcept C8010536 @default.
• W2020033079 hasConcept C86803240 @default.
• W2020033079 hasConcept C91881484 @default.
• W2020033079 hasConceptScore W2020033079C111921641 @default.
• W2020033079 hasConceptScore W2020033079C121332964 @default.
• W2020033079 hasConceptScore W2020033079C137824038 @default.
• W2020033079 hasConceptScore W2020033079C179104552 @default.
• W2020033079 hasConceptScore W2020033079C185581394 @default.
• W2020033079 hasConceptScore W2020033079C185592680 @default.
• W2020033079 hasConceptScore W2020033079C2777272437 @default.
• W2020033079 hasConceptScore W2020033079C2780283098 @default.
• W2020033079 hasConceptScore W2020033079C523546767 @default.
• W2020033079 hasConceptScore W2020033079C54355233 @default.
• W2020033079 hasConceptScore W2020033079C552990157 @default.
• W2020033079 hasConceptScore W2020033079C55493867 @default.
• W2020033079 hasConceptScore W2020033079C62520636 @default.
• W2020033079 hasConceptScore W2020033079C71240020 @default.
• W2020033079 hasConceptScore W2020033079C8010536 @default.
• W2020033079 hasConceptScore W2020033079C86803240 @default.
• W2020033079 hasConceptScore W2020033079C91881484 @default.
• W2020033079 hasIssue "3" @default.
• W2020033079 hasLocation W20200330791 @default.
• W2020033079 hasLocation W20200330792 @default.
• W2020033079 hasLocation W20200330793 @default.
• W2020033079 hasLocation W20200330794 @default.
• W2020033079 hasOpenAccess W2020033079 @default.
• W2020033079 hasPrimaryLocation W20200330791 @default.
• W2020033079 hasRelatedWork W1984996905 @default.

• next