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- W2020035623 abstract "18-Methoxycoronaridine (18-MC), a selective antagonist of α3β4 nicotinic receptors, has been shown to reduce the self-administration of several drugs of abuse. Recently, this agent has also been shown to attenuate sucrose reward, decrease sucrose intake and prevent the development of sucrose-induced obesity in rats. The present experiments were designed to determine whether the latter effect was due to an 18-MC-induced conditioned taste aversion to sucrose. Both 18-MC (20 mg/ kg, i.p.) and control agent, lithium chloride (100 mg/kg, i.p.), reduced sucrose intake 24 h after association with sucrose; however, only lithium chloride reduced sucrose intake 72 h later. Consistent with previous data, 18-MC appears to have proactive effect for 24 h and it does not induce a conditioned taste aversion." @default.
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- W2020035623 date "2010-09-01" @default.
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- W2020035623 title "18-Methoxycoronaridine, a potential anti-obesity agent, does not produce a conditioned taste aversion in rats" @default.
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- W2020035623 doi "https://doi.org/10.1016/j.pbb.2010.05.002" @default.
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