Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020036246> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2020036246 endingPage "365" @default.
- W2020036246 startingPage "353" @default.
- W2020036246 abstract "Abstract Amiodarone is an antiarrhythmic drug with numerous side effects, the most serious being the development of pulmonary toxicity. We have previously reported that a single intratra cheal instillation of amiodarone to Fischer 344 rats results in pulmonary fibrosis within 6 wk of treatment. Presently, the mechanism of amiodarone-induced pulmonary toxicity is unknown. Cytokines that stimulate fibroblast proliferation and/or collagen production may play a role in amiodarone-induced pulmonary toxicity. To investigate this possibility, female rats were given a single intratracheal instillation of amiodarone (6.25 mg/kg), its metabolite desethylamiodarone (5 mg/kg), or vehicle (sterile water). At I, 2, 3, or 6 wk after treatment the lungs were lavaged and the recovered cells were counted and identi fied. The alveolar macrophages were isolated by attachment to plastic petri dishes, cul tured overnight, and the spent media collected for tumor necrosis factor alpha (TNF-α) and transforming growth factor beta (TGF-β) analyses. Desethylamiodarone treatment resulted in a neutrophilic alveolitis, but the levels of TNF-α and TGF-β were not signifi cantly different from control animals. In contrast, amiodarone treatment resulted in a lym phocytic alveolitis and significantly higher amounts of TNF-α were observed at 3 and 6 wk after treatment. A trend toward higher levels of TCF-β was also noted in the amio-darone-treated group at wk 1-3 but the values were not significantly different from those of controls. In conclusion, the release of TNF-α may play a role in the development of amiodarone-induced pulmonary toxicity." @default.
- W2020036246 created "2016-06-24" @default.
- W2020036246 creator A5041570231 @default.
- W2020036246 creator A5065164142 @default.
- W2020036246 date "1997-11-01" @default.
- W2020036246 modified "2023-10-16" @default.
- W2020036246 title "AMIODARONE-INDUCED PULMONARY TOXICITY IN FISCHER RATS: RELEASE OF TUMOR NECROSIS FACTOR ALPHA AND TRANSFORMING GROWTH FACTOR BETA BY PULMONARY ALVEOLAR MACROPHAGES" @default.
- W2020036246 cites W1505978562 @default.
- W2020036246 cites W1575623224 @default.
- W2020036246 cites W1578996543 @default.
- W2020036246 cites W1581990512 @default.
- W2020036246 cites W1963670501 @default.
- W2020036246 cites W1966383754 @default.
- W2020036246 cites W1986609384 @default.
- W2020036246 cites W1986926395 @default.
- W2020036246 cites W2002494214 @default.
- W2020036246 cites W2005139961 @default.
- W2020036246 cites W2007451263 @default.
- W2020036246 cites W2014981185 @default.
- W2020036246 cites W2019521359 @default.
- W2020036246 cites W2022799559 @default.
- W2020036246 cites W2046196550 @default.
- W2020036246 cites W2051476593 @default.
- W2020036246 cites W2064566876 @default.
- W2020036246 cites W2071948358 @default.
- W2020036246 cites W2077928990 @default.
- W2020036246 cites W2101157641 @default.
- W2020036246 cites W2111803376 @default.
- W2020036246 cites W2116656764 @default.
- W2020036246 cites W2122794487 @default.
- W2020036246 cites W2133614172 @default.
- W2020036246 cites W2317458904 @default.
- W2020036246 cites W2322631380 @default.
- W2020036246 cites W2322672599 @default.
- W2020036246 doi "https://doi.org/10.1080/00984109708984070" @default.
- W2020036246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9354180" @default.
- W2020036246 hasPublicationYear "1997" @default.
- W2020036246 type Work @default.
- W2020036246 sameAs 2020036246 @default.
- W2020036246 citedByCount "26" @default.
- W2020036246 countsByYear W20200362462013 @default.
- W2020036246 countsByYear W20200362462014 @default.
- W2020036246 countsByYear W20200362462015 @default.
- W2020036246 countsByYear W20200362462019 @default.
- W2020036246 countsByYear W20200362462021 @default.
- W2020036246 countsByYear W20200362462022 @default.
- W2020036246 crossrefType "journal-article" @default.
- W2020036246 hasAuthorship W2020036246A5041570231 @default.
- W2020036246 hasAuthorship W2020036246A5065164142 @default.
- W2020036246 hasConcept C118131993 @default.
- W2020036246 hasConcept C126322002 @default.
- W2020036246 hasConcept C134018914 @default.
- W2020036246 hasConcept C17991360 @default.
- W2020036246 hasConcept C2777477808 @default.
- W2020036246 hasConcept C2777714996 @default.
- W2020036246 hasConcept C2778094803 @default.
- W2020036246 hasConcept C2779161974 @default.
- W2020036246 hasConcept C2781047374 @default.
- W2020036246 hasConcept C2781244666 @default.
- W2020036246 hasConcept C29730261 @default.
- W2020036246 hasConcept C71924100 @default.
- W2020036246 hasConcept C98274493 @default.
- W2020036246 hasConceptScore W2020036246C118131993 @default.
- W2020036246 hasConceptScore W2020036246C126322002 @default.
- W2020036246 hasConceptScore W2020036246C134018914 @default.
- W2020036246 hasConceptScore W2020036246C17991360 @default.
- W2020036246 hasConceptScore W2020036246C2777477808 @default.
- W2020036246 hasConceptScore W2020036246C2777714996 @default.
- W2020036246 hasConceptScore W2020036246C2778094803 @default.
- W2020036246 hasConceptScore W2020036246C2779161974 @default.
- W2020036246 hasConceptScore W2020036246C2781047374 @default.
- W2020036246 hasConceptScore W2020036246C2781244666 @default.
- W2020036246 hasConceptScore W2020036246C29730261 @default.
- W2020036246 hasConceptScore W2020036246C71924100 @default.
- W2020036246 hasConceptScore W2020036246C98274493 @default.
- W2020036246 hasIssue "4" @default.
- W2020036246 hasLocation W20200362461 @default.
- W2020036246 hasLocation W20200362462 @default.
- W2020036246 hasOpenAccess W2020036246 @default.
- W2020036246 hasPrimaryLocation W20200362461 @default.
- W2020036246 hasRelatedWork W1579452791 @default.
- W2020036246 hasRelatedWork W2012664272 @default.
- W2020036246 hasRelatedWork W2039283082 @default.
- W2020036246 hasRelatedWork W2077928990 @default.
- W2020036246 hasRelatedWork W2083935405 @default.
- W2020036246 hasRelatedWork W2087208771 @default.
- W2020036246 hasRelatedWork W2317458904 @default.
- W2020036246 hasRelatedWork W2766302983 @default.
- W2020036246 hasRelatedWork W38081694 @default.
- W2020036246 hasRelatedWork W4230390259 @default.
- W2020036246 hasVolume "52" @default.
- W2020036246 isParatext "false" @default.
- W2020036246 isRetracted "false" @default.
- W2020036246 magId "2020036246" @default.
- W2020036246 workType "article" @default.