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- W2020042521 abstract "SPf66 is a synthetic malaria vaccine containing peptides derived from three asexual blood-stage proteins of Plasmodium falciparum[ 1 Pattaroyo M et al. Nature. 1988; 332: 158-161 Crossref PubMed Scopus (328) Google Scholar ]. In Parasitology Today, Gilbert and Hill[ 2 Gilbert S.C Hill A.V.S Parasitol. Today. 1997; 13: 302-306 Abstract Full Text PDF PubMed Scopus (8) Google Scholar ]stated that `recently, extensive testing of the candidate vaccine SPf66 led to the disappointing conclusion that SPf66 does not protect against clinical malaria, and that further efficacy trials are not warranted'. The authors cite one trial of SPf66 with a negative result as support for their statement[ 3 Nosten F et al. Lancet. 1996; 348: 701-707 Abstract Full Text Full Text PDF PubMed Scopus (144) Google Scholar ]. However, the vaccine has been tested in eight published trials in malaria-endemic areas, with varying results. We re-examine the evidence for Gilbert and Hill's statement, based on a systematic review and meta-analysis (mathematical synthesis) of all the available unbiased evidence from malaria vaccine trials[ 4 Graves, P. (1997) in Infectious Diseases Module of The Cochrane Database of Systematic Reviews (updated 3 June 1997) (Garner, P. et al., eds). Available in The Cochrane Library (database on disk and CD-ROM). The Cochrane Collaboration; Issue 4. Oxford: Update Software; 1997. Updated quarterly Google Scholar ]. The review is published and continuously updated on CD-ROM in the Cochrane Library (http://www.cochrane.co.uk)." @default.
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- W2020042521 title "The SPf66 Malaria Vaccine: What is the Evidence for Efficacy?" @default.
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- W2020042521 doi "https://doi.org/10.1016/s0169-4758(98)01242-3" @default.
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