FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020046473> ?p ?o ?g. }

• W2020046473 endingPage "e30769" @default.
• W2020046473 startingPage "e30769" @default.
• W2020046473 abstract "Malignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis. The Raf Kinase Inhibitory protein (RKIP), besides regulating important intracellular signaling cascades, was described to be associated with progression, metastasis and prognosis in several human neoplasms. Its role in the prognosis and tumourigenesis of gliomas remains unclear. In the present study, we found that RKIP protein is absent in a low frequency (10%, 20/193) of glioma tumors. Nevertheless, the absence of RKIP expression was an independent prognostic marker in glioma. Additionally, by in vitro downregulation of RKIP, we found that RKIP inhibition induces a higher viability and migration of the cells, having no effect on cellular proliferation and angiogenesis, as assessed by in vivo CAM assay. In conclusion, this is the largest series studied so far evaluating the expression levels of this important cancer suppressor protein in glioma tumors. Our results suggest that in a subset of tumors, the absence of RKIP associates with highly malignant behavior and poor survival of patients, which may be a useful biomarker for tailored treatment of glioma patients." @default.
• W2020046473 created "2016-06-24" @default.
• W2020046473 creator A5007918328 @default.
• W2020046473 creator A5023130252 @default.
• W2020046473 creator A5031152359 @default.
• W2020046473 creator A5035432368 @default.
• W2020046473 creator A5035583989 @default.
• W2020046473 creator A5046922498 @default.
• W2020046473 creator A5047929505 @default.
• W2020046473 creator A5070707567 @default.
• W2020046473 creator A5077097460 @default.
• W2020046473 creator A5077714604 @default.
• W2020046473 creator A5079332431 @default.
• W2020046473 date "2012-01-23" @default.
• W2020046473 modified "2023-10-12" @default.
• W2020046473 title "Downregulation of RKIP Is Associated with Poor Outcome and Malignant Progression in Gliomas" @default.
• W2020046473 cites W1964123122 @default.
• W2020046473 cites W1964630467 @default.
• W2020046473 cites W1968205972 @default.
• W2020046473 cites W1975403276 @default.
• W2020046473 cites W1977983659 @default.
• W2020046473 cites W1978837966 @default.
• W2020046473 cites W1979008438 @default.
• W2020046473 cites W1983784090 @default.
• W2020046473 cites W1984166243 @default.
• W2020046473 cites W1984569351 @default.
• W2020046473 cites W1993338076 @default.
• W2020046473 cites W2018457162 @default.
• W2020046473 cites W2022059232 @default.
• W2020046473 cites W2026593149 @default.
• W2020046473 cites W2030063660 @default.
• W2020046473 cites W2036044314 @default.
• W2020046473 cites W2046286252 @default.
• W2020046473 cites W2057811067 @default.
• W2020046473 cites W2069350121 @default.
• W2020046473 cites W2069523988 @default.
• W2020046473 cites W2075309217 @default.
• W2020046473 cites W2077988792 @default.
• W2020046473 cites W2084170466 @default.
• W2020046473 cites W2094500459 @default.
• W2020046473 cites W2094942306 @default.
• W2020046473 cites W2104227964 @default.
• W2020046473 cites W2106435751 @default.
• W2020046473 cites W2111217479 @default.
• W2020046473 cites W2118411892 @default.
• W2020046473 cites W2126934083 @default.
• W2020046473 cites W2129269004 @default.
• W2020046473 cites W2130819349 @default.
• W2020046473 cites W2131605616 @default.
• W2020046473 cites W2132974858 @default.
• W2020046473 cites W2135803007 @default.
• W2020046473 cites W2142242441 @default.
• W2020046473 cites W2142308379 @default.
• W2020046473 cites W2160382843 @default.
• W2020046473 cites W2164363164 @default.
• W2020046473 cites W2164385994 @default.
• W2020046473 cites W2167689405 @default.
• W2020046473 cites W2168960151 @default.
• W2020046473 doi "https://doi.org/10.1371/journal.pone.0030769" @default.
• W2020046473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3264629" @default.
• W2020046473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22292035" @default.
• W2020046473 hasPublicationYear "2012" @default.
• W2020046473 type Work @default.
• W2020046473 sameAs 2020046473 @default.
• W2020046473 citedByCount "53" @default.
• W2020046473 countsByYear W20200464732012 @default.
• W2020046473 countsByYear W20200464732013 @default.
• W2020046473 countsByYear W20200464732014 @default.
• W2020046473 countsByYear W20200464732015 @default.
• W2020046473 countsByYear W20200464732016 @default.
• W2020046473 countsByYear W20200464732017 @default.
• W2020046473 countsByYear W20200464732018 @default.
• W2020046473 countsByYear W20200464732019 @default.
• W2020046473 countsByYear W20200464732020 @default.
• W2020046473 countsByYear W20200464732021 @default.
• W2020046473 countsByYear W20200464732022 @default.
• W2020046473 crossrefType "journal-article" @default.
• W2020046473 hasAuthorship W2020046473A5007918328 @default.
• W2020046473 hasAuthorship W2020046473A5023130252 @default.
• W2020046473 hasAuthorship W2020046473A5031152359 @default.
• W2020046473 hasAuthorship W2020046473A5035432368 @default.
• W2020046473 hasAuthorship W2020046473A5035583989 @default.
• W2020046473 hasAuthorship W2020046473A5046922498 @default.
• W2020046473 hasAuthorship W2020046473A5047929505 @default.
• W2020046473 hasAuthorship W2020046473A5070707567 @default.
• W2020046473 hasAuthorship W2020046473A5077097460 @default.
• W2020046473 hasAuthorship W2020046473A5077714604 @default.
• W2020046473 hasAuthorship W2020046473A5079332431 @default.
• W2020046473 hasBestOaLocation W20200464733 @default.
• W2020046473 hasConcept C104317684 @default.
• W2020046473 hasConcept C121608353 @default.
• W2020046473 hasConcept C126322002 @default.
• W2020046473 hasConcept C127561419 @default.
• W2020046473 hasConcept C127716648 @default.
• W2020046473 hasConcept C142724271 @default.
• W2020046473 hasConcept C179185449 @default.
• W2020046473 hasConcept C2778227246 @default.
• W2020046473 hasConcept C2779013556 @default.

• next