Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020046716> ?p ?o ?g. }
- W2020046716 endingPage "206" @default.
- W2020046716 startingPage "199" @default.
- W2020046716 abstract "Hypoxic, non-functional, but viable, tissue may exist in heart and brain following an arterial occlusion. Identification of such tissue in vivo is crucial to the development of effective treatment strategies. It has been suggested that certain compounds capable of sensitizing hypoxic tumor cells to killing by x-rays (i.e., misonidazole) might serve as in vivo markers of hypoxic tissue in ischemic myocardium or brain if properly radiolabeled. To this end we have radiolabeled two fluorinated analogs of nitroimidazole based hypoxic cell sensitizers with the 110 minute half-lived positron-emitting fluorine-18. The ability of these tracers to quantitate the presence of hypoxic tissue has been studied in a gerbil stroke model. The in vivo uptake of one of these tracers [F-18]-fluoronormethyoxymisonidazole is dependent on the extent of tissue hypoxia, and thus, appears to have potential as a diagnostic indicator of non-functional but viable tissue when the tracer is used in conjunction with positron emission tomography." @default.
- W2020046716 created "2016-06-24" @default.
- W2020046716 creator A5034121696 @default.
- W2020046716 creator A5039215935 @default.
- W2020046716 creator A5042427394 @default.
- W2020046716 creator A5046436153 @default.
- W2020046716 creator A5047930377 @default.
- W2020046716 creator A5048469918 @default.
- W2020046716 creator A5054362948 @default.
- W2020046716 creator A5066557860 @default.
- W2020046716 creator A5071547258 @default.
- W2020046716 date "1987-07-01" @default.
- W2020046716 modified "2023-10-16" @default.
- W2020046716 title "Radiolabeled hypoxic cell sensitizers: Tracers for assessment of ischemia" @default.
- W2020046716 cites W1159538718 @default.
- W2020046716 cites W1900054334 @default.
- W2020046716 cites W1964306615 @default.
- W2020046716 cites W1969177824 @default.
- W2020046716 cites W1970948726 @default.
- W2020046716 cites W1971607332 @default.
- W2020046716 cites W1974335594 @default.
- W2020046716 cites W1974789643 @default.
- W2020046716 cites W1976311564 @default.
- W2020046716 cites W1979935420 @default.
- W2020046716 cites W1985238455 @default.
- W2020046716 cites W1988578912 @default.
- W2020046716 cites W1994216439 @default.
- W2020046716 cites W2001689281 @default.
- W2020046716 cites W2005733600 @default.
- W2020046716 cites W2005818340 @default.
- W2020046716 cites W2011636435 @default.
- W2020046716 cites W2013280216 @default.
- W2020046716 cites W2013317091 @default.
- W2020046716 cites W2014044319 @default.
- W2020046716 cites W2015859554 @default.
- W2020046716 cites W2018239968 @default.
- W2020046716 cites W2018535864 @default.
- W2020046716 cites W2021394070 @default.
- W2020046716 cites W2030892741 @default.
- W2020046716 cites W2038909506 @default.
- W2020046716 cites W2047488937 @default.
- W2020046716 cites W2048014643 @default.
- W2020046716 cites W2051284997 @default.
- W2020046716 cites W2052048298 @default.
- W2020046716 cites W2062364439 @default.
- W2020046716 cites W2069768821 @default.
- W2020046716 cites W2079249748 @default.
- W2020046716 cites W2085149684 @default.
- W2020046716 cites W2085393987 @default.
- W2020046716 cites W2089195256 @default.
- W2020046716 cites W2091227588 @default.
- W2020046716 cites W2096021091 @default.
- W2020046716 cites W2101317014 @default.
- W2020046716 cites W2117172839 @default.
- W2020046716 cites W2117374129 @default.
- W2020046716 cites W2121763255 @default.
- W2020046716 cites W2124725117 @default.
- W2020046716 cites W2142778735 @default.
- W2020046716 cites W2147183676 @default.
- W2020046716 cites W2147767750 @default.
- W2020046716 cites W2153636781 @default.
- W2020046716 cites W2157607856 @default.
- W2020046716 cites W2162637508 @default.
- W2020046716 cites W2167229055 @default.
- W2020046716 cites W2300809561 @default.
- W2020046716 cites W2319463151 @default.
- W2020046716 cites W2319511828 @default.
- W2020046716 cites W2323427177 @default.
- W2020046716 cites W2328736834 @default.
- W2020046716 cites W2616852889 @default.
- W2020046716 doi "https://doi.org/10.1016/0024-3205(87)90494-2" @default.
- W2020046716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3600179" @default.
- W2020046716 hasPublicationYear "1987" @default.
- W2020046716 type Work @default.
- W2020046716 sameAs 2020046716 @default.
- W2020046716 citedByCount "33" @default.
- W2020046716 countsByYear W20200467162012 @default.
- W2020046716 countsByYear W20200467162013 @default.
- W2020046716 countsByYear W20200467162014 @default.
- W2020046716 countsByYear W20200467162016 @default.
- W2020046716 crossrefType "journal-article" @default.
- W2020046716 hasAuthorship W2020046716A5034121696 @default.
- W2020046716 hasAuthorship W2020046716A5039215935 @default.
- W2020046716 hasAuthorship W2020046716A5042427394 @default.
- W2020046716 hasAuthorship W2020046716A5046436153 @default.
- W2020046716 hasAuthorship W2020046716A5047930377 @default.
- W2020046716 hasAuthorship W2020046716A5048469918 @default.
- W2020046716 hasAuthorship W2020046716A5054362948 @default.
- W2020046716 hasAuthorship W2020046716A5066557860 @default.
- W2020046716 hasAuthorship W2020046716A5071547258 @default.
- W2020046716 hasConcept C136229726 @default.
- W2020046716 hasConcept C142724271 @default.
- W2020046716 hasConcept C150903083 @default.
- W2020046716 hasConcept C164705383 @default.
- W2020046716 hasConcept C178790620 @default.
- W2020046716 hasConcept C185592680 @default.
- W2020046716 hasConcept C202751555 @default.
- W2020046716 hasConcept C207001950 @default.