Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020046872> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2020046872 abstract "The availability of a microemulsion formulation (ME) of cyclosporin (CyA) displays improved bioavailability and reduced inter and intra-patient variability, resulting in improved long-term outcomes. Recent developments in therapeutic drug monitoring stress the need to optimize peak drug levels during the early posttransplant period to obtain long-term benefit.We studied early CyA-ME pharmacokinetics, comparing pre- versus immediate posttransplant values, to assess predictability of pre-transplant profiles in 22 patients including 3 diabetics. An 8 mg/kg per day amount in two divided doses was administered, for 5 days pretransplant and 10-14 days posttransplant before performing the pharmacokinetic studies. Drugs interacting with CyA metabolism/absorption were withdrawn and patients with liver disease were excluded the CyA level monitoring used a 5-point blood sampling (at 0 hours, 1 hours, 2 hours, 3 hours, and 4 hours post-dose). The study compared actual concentrations at each individual time and the limited 0-4 hour AUC.The paired values at each point pre- and posttransplant were: C0 = 171 +/- 63 and 215 +/- 112, C1 = 723.86 +/- 345 and 1239.95 +/- 415, C2 = 972 +/- 185 and 1249.95 +/- 336, C3 = 822 +/- 242 and 942.7 +/- 286, and C4 = 601.54 +/- 190 and 670.5 +/- 208 ng/mL respectively. The C1 and C2 values were significantly higher posttransplant (P =.008 and 0.0045 respectively), suggesting a steeper absorption phase, a conclusion consistent with the higher 0-4 hour AUC posttransplant (P =.0089). However, linear regression analysis of pre- versus posttransplant values showed poor correlations.CyA absorption is significantly lower among patients on maintenance hemodialysis and showed no predictive correlation with posttransplant levels. The possible role of uremia in retarding absorption which may have clinical significance for primary graft dysfunction, needs further evaluation." @default.
- W2020046872 created "2016-06-24" @default.
- W2020046872 creator A5007096990 @default.
- W2020046872 creator A5007302042 @default.
- W2020046872 creator A5010134311 @default.
- W2020046872 creator A5061870584 @default.
- W2020046872 creator A5069140394 @default.
- W2020046872 creator A5086952950 @default.
- W2020046872 date "2003-06-01" @default.
- W2020046872 modified "2023-09-27" @default.
- W2020046872 title "Pre– and postrenal transplantation pharmacokinetics of cyclosporine microemulsion" @default.
- W2020046872 cites W1973091323 @default.
- W2020046872 cites W1981801952 @default.
- W2020046872 cites W2002514824 @default.
- W2020046872 cites W2015500397 @default.
- W2020046872 cites W2031731525 @default.
- W2020046872 cites W2052576448 @default.
- W2020046872 cites W2056810545 @default.
- W2020046872 cites W2069388748 @default.
- W2020046872 cites W2082014437 @default.
- W2020046872 cites W2086101296 @default.
- W2020046872 cites W2156329900 @default.
- W2020046872 cites W2466527365 @default.
- W2020046872 doi "https://doi.org/10.1016/s0041-1345(03)00474-3" @default.
- W2020046872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12826141" @default.
- W2020046872 hasPublicationYear "2003" @default.
- W2020046872 type Work @default.
- W2020046872 sameAs 2020046872 @default.
- W2020046872 citedByCount "8" @default.
- W2020046872 countsByYear W20200468722013 @default.
- W2020046872 countsByYear W20200468722017 @default.
- W2020046872 crossrefType "journal-article" @default.
- W2020046872 hasAuthorship W2020046872A5007096990 @default.
- W2020046872 hasAuthorship W2020046872A5007302042 @default.
- W2020046872 hasAuthorship W2020046872A5010134311 @default.
- W2020046872 hasAuthorship W2020046872A5061870584 @default.
- W2020046872 hasAuthorship W2020046872A5069140394 @default.
- W2020046872 hasAuthorship W2020046872A5086952950 @default.
- W2020046872 hasConcept C112705442 @default.
- W2020046872 hasConcept C141071460 @default.
- W2020046872 hasConcept C177713679 @default.
- W2020046872 hasConcept C181389837 @default.
- W2020046872 hasConcept C2780035454 @default.
- W2020046872 hasConcept C2780272996 @default.
- W2020046872 hasConcept C2911091166 @default.
- W2020046872 hasConcept C71924100 @default.
- W2020046872 hasConcept C98274493 @default.
- W2020046872 hasConceptScore W2020046872C112705442 @default.
- W2020046872 hasConceptScore W2020046872C141071460 @default.
- W2020046872 hasConceptScore W2020046872C177713679 @default.
- W2020046872 hasConceptScore W2020046872C181389837 @default.
- W2020046872 hasConceptScore W2020046872C2780035454 @default.
- W2020046872 hasConceptScore W2020046872C2780272996 @default.
- W2020046872 hasConceptScore W2020046872C2911091166 @default.
- W2020046872 hasConceptScore W2020046872C71924100 @default.
- W2020046872 hasConceptScore W2020046872C98274493 @default.
- W2020046872 hasLocation W20200468721 @default.
- W2020046872 hasLocation W20200468722 @default.
- W2020046872 hasOpenAccess W2020046872 @default.
- W2020046872 hasPrimaryLocation W20200468721 @default.
- W2020046872 hasRelatedWork W118449968 @default.
- W2020046872 hasRelatedWork W1970331292 @default.
- W2020046872 hasRelatedWork W2080955156 @default.
- W2020046872 hasRelatedWork W2083067870 @default.
- W2020046872 hasRelatedWork W2131557988 @default.
- W2020046872 hasRelatedWork W2400119402 @default.
- W2020046872 hasRelatedWork W2606334551 @default.
- W2020046872 hasRelatedWork W2797990875 @default.
- W2020046872 hasRelatedWork W2992077105 @default.
- W2020046872 hasRelatedWork W3024440267 @default.
- W2020046872 isParatext "false" @default.
- W2020046872 isRetracted "false" @default.
- W2020046872 magId "2020046872" @default.
- W2020046872 workType "article" @default.