Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020047599> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2020047599 endingPage "152A" @default.
- W2020047599 startingPage "152A" @default.
- W2020047599 abstract "Imipenem (Im) (thienamycin, MKO787/MKO791), a new β-lactam antibiotic, has outstanding potency against gram positive, gram negative, aerobic and anaerobic bacteria, including Pseudomonas aeruginosa. Selected pharmacokinetic and safety parameters were studied in children in anticipation of clinical therapeutic trials. A single dose (10 or 25 mg/kg) of Im was given intravenously to eight children aged 2-12 years hospitalized and receiving conventional intravenous antibiotics for suspected or proven infection. Plasma samples were obtained at 1 min, 30 min, 1, 2, 4, and 6 hours after the completion of the Im infusion. Random urine samples were also obtained. Im concentrations were measured by high performance liquid chromatography. Interpretation of the data was based on a one compartment open model. Selected parameters (means ± S.D.) are as follows: No adverse clinical or laboratory effects were noted. Based on these data and Im's in vitro activity, a dose of 25 mg/kg, intravenously every 4-6 hours, would likely be safe and provide therapeutic serum and urine concentrations in clinical trials in pediatric patients." @default.
- W2020047599 created "2016-06-24" @default.
- W2020047599 creator A5001380464 @default.
- W2020047599 creator A5005363507 @default.
- W2020047599 creator A5025743275 @default.
- W2020047599 creator A5037354328 @default.
- W2020047599 creator A5031166323 @default.
- W2020047599 date "1984-04-01" @default.
- W2020047599 modified "2023-09-27" @default.
- W2020047599 title "IMIPENEM PHARMACOKINETICS IN CHILDREN" @default.
- W2020047599 doi "https://doi.org/10.1203/00006450-198404001-00355" @default.
- W2020047599 hasPublicationYear "1984" @default.
- W2020047599 type Work @default.
- W2020047599 sameAs 2020047599 @default.
- W2020047599 citedByCount "0" @default.
- W2020047599 crossrefType "journal-article" @default.
- W2020047599 hasAuthorship W2020047599A5001380464 @default.
- W2020047599 hasAuthorship W2020047599A5005363507 @default.
- W2020047599 hasAuthorship W2020047599A5025743275 @default.
- W2020047599 hasAuthorship W2020047599A5031166323 @default.
- W2020047599 hasAuthorship W2020047599A5037354328 @default.
- W2020047599 hasBestOaLocation W20200475991 @default.
- W2020047599 hasConcept C112705442 @default.
- W2020047599 hasConcept C126322002 @default.
- W2020047599 hasConcept C185592680 @default.
- W2020047599 hasConcept C197934379 @default.
- W2020047599 hasConcept C202751555 @default.
- W2020047599 hasConcept C2776432923 @default.
- W2020047599 hasConcept C2777637488 @default.
- W2020047599 hasConcept C2777870638 @default.
- W2020047599 hasConcept C2779631663 @default.
- W2020047599 hasConcept C2780026642 @default.
- W2020047599 hasConcept C42219234 @default.
- W2020047599 hasConcept C501593827 @default.
- W2020047599 hasConcept C523546767 @default.
- W2020047599 hasConcept C535046627 @default.
- W2020047599 hasConcept C54355233 @default.
- W2020047599 hasConcept C55493867 @default.
- W2020047599 hasConcept C57992300 @default.
- W2020047599 hasConcept C71924100 @default.
- W2020047599 hasConcept C86803240 @default.
- W2020047599 hasConcept C89423630 @default.
- W2020047599 hasConcept C94665300 @default.
- W2020047599 hasConcept C98274493 @default.
- W2020047599 hasConceptScore W2020047599C112705442 @default.
- W2020047599 hasConceptScore W2020047599C126322002 @default.
- W2020047599 hasConceptScore W2020047599C185592680 @default.
- W2020047599 hasConceptScore W2020047599C197934379 @default.
- W2020047599 hasConceptScore W2020047599C202751555 @default.
- W2020047599 hasConceptScore W2020047599C2776432923 @default.
- W2020047599 hasConceptScore W2020047599C2777637488 @default.
- W2020047599 hasConceptScore W2020047599C2777870638 @default.
- W2020047599 hasConceptScore W2020047599C2779631663 @default.
- W2020047599 hasConceptScore W2020047599C2780026642 @default.
- W2020047599 hasConceptScore W2020047599C42219234 @default.
- W2020047599 hasConceptScore W2020047599C501593827 @default.
- W2020047599 hasConceptScore W2020047599C523546767 @default.
- W2020047599 hasConceptScore W2020047599C535046627 @default.
- W2020047599 hasConceptScore W2020047599C54355233 @default.
- W2020047599 hasConceptScore W2020047599C55493867 @default.
- W2020047599 hasConceptScore W2020047599C57992300 @default.
- W2020047599 hasConceptScore W2020047599C71924100 @default.
- W2020047599 hasConceptScore W2020047599C86803240 @default.
- W2020047599 hasConceptScore W2020047599C89423630 @default.
- W2020047599 hasConceptScore W2020047599C94665300 @default.
- W2020047599 hasConceptScore W2020047599C98274493 @default.
- W2020047599 hasLocation W20200475991 @default.
- W2020047599 hasOpenAccess W2020047599 @default.
- W2020047599 hasPrimaryLocation W20200475991 @default.
- W2020047599 hasRelatedWork W1999972235 @default.
- W2020047599 hasRelatedWork W2048961294 @default.
- W2020047599 hasRelatedWork W2080418616 @default.
- W2020047599 hasRelatedWork W2346829290 @default.
- W2020047599 hasRelatedWork W2358008552 @default.
- W2020047599 hasRelatedWork W2361370693 @default.
- W2020047599 hasRelatedWork W2365028138 @default.
- W2020047599 hasRelatedWork W2384165692 @default.
- W2020047599 hasRelatedWork W2410334608 @default.
- W2020047599 hasRelatedWork W2419471427 @default.
- W2020047599 hasVolume "18" @default.
- W2020047599 isParatext "false" @default.
- W2020047599 isRetracted "false" @default.
- W2020047599 magId "2020047599" @default.
- W2020047599 workType "article" @default.